DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8243 and asap2

DIOPT Version :9

Sequence 1:	NP_610424.1	Gene:	CG8243 / 35890	FlyBaseID:	FBgn0033349	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	XP_002935078.3	Gene:	asap2 / 100494274	XenbaseID:	XB-GENE-1002636	Length:	1025	Species:	Xenopus tropicalis

Alignment Length:	569	Identity:	135/569 - (23%)
Similarity:	218/569 - (38%)	Gaps:	96/569 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NAGQRTKLIQEKCQTLLTQMLRDEDNKYCVDCDAKGPRWASWNLGMFLCIRCAGIHRNLGVHISR 69
            :||: ..::||..:.:::.:.|...|..|.||.|..|.|.|.|||:..||.|:||||.||||.||
Frog   409 SAGE-NNIVQELTKEIISDIQRMPGNDVCCDCGASDPTWLSTNLGILTCIECSGIHRELGVHYSR 472

  Fly    70 VKSVNLDTWTPEQVISLQQMGNSRARAVYEAQLP--DGFR-RPQTD-TALENFIRAKYEHKKYLA 130
            ::|:.||.....:::..:.:|||....:.||.||  |..: .|.:| .|.:::|..||..:||..
Frog   473 IQSLTLDVLGTSELLLAKNIGNSGFNELMEACLPADDSVKPSPCSDMNARKDYITTKYIERKYAR 537

  Fly   131 REWVPPSPPKVDWAKEIDEELERQKRKKKSTQAQ-------ATLGLAGVAGG--SGDKRLSGSSA 186
            |::       .|.|.::....:..|.:...|..|       .|.|:. :|.|  .|:..|..:..
Frog   538 RKY-------HDNASKLHGLCDAVKSRDIFTLVQLHAEGVDLTEGIP-LANGHEQGETALHLAVR 594

  Fly   187 SALKNT------------PLPAPLPKPKPNQVGGCSPKTTQRVQLNSSGVSS------AGESDLL 233
            |..:|:            .|.....|........|.....:.::|...|.:|      |||:. |
Frog   595 SVDRNSLHIVDFLVQNSGNLDKQTAKGSTALHYCCLTDNAECLKLLLRGKASTDIANDAGETP-L 658

  Fly   234 GLSSPTKPIVATNASQDLQNESFTSFLSAESIAGQPDKPIGSNGDAANLMGSKPNSLAQEEQ--D 296
            .::...|.....:......|..|.:.:..|.........:..:.|..:....:|:.:.:||:  .
Frog   659 DIAKRLKHAQCEDLLIQAMNGRFNAHVHVEYEWRLHHMDLDESDDDMDEKIQQPSPIRREERPVS 723

  Fly   297 FF--NQG--SLGAGGNEKDQSGKMSKDSILALYGSAPATHNPQM----NFGGFTG--MAPGGYMH 351
            ||  |||  |:.....|   :..::||.        |.|..|.:    .:|...|  .:||....
Frog   724 FFGINQGQPSVACLARE---AASIAKDK--------PRTFLPNIIQNETYGAVIGNSNSPGNATG 777

  Fly   352 QQQQQQIPHQFMTPPNSV----SMYNSPVMAAPNAFSNAAISSATAMSMGGSHGFTGAQFPSTGG 412
            .......|   :.|.|::    :::.|.:...|:.......||.|..|  ||...:.:..||...
Frog   778 PSTTNAPP---LPPRNTIKVHSTIFGSSIHPTPSNTPAWKASSVTPES--GSRQRSSSDPPSIQP 837

  Fly   413 SPYAAAGQAAATN----------------LMQ-TNQSILSGMPLFGAVPQ--QQQQHQQQLQQQH 458
            ........:.|||                |.| :.||....:||...||.  ..|...:.|.::.
Frog   838 PVPPVRVTSTATNSPPPPPVTKTASVIEALSQHSKQSPPPPVPLNKPVPPPVPPQPANRPLHKRP 902

  Fly   459 HPQLGGLSMNLMQPLPSGLNIGQPPQGAGGFAA--TGPTTSSVPSNLNQ 505
            .|.:.........|.|:  .:..||..|..|.:  |.....|.|||..|
Frog   903 APGIDKPPPTAKGPPPA--LVTAPPSAAAEFPSDTTALQPGSKPSNRTQ 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8243	NP_610424.1	ArfGap	18..132	CDD:279720	44/117 (38%)
CG8243	NP_610424.1	COG5347	20..300	CDD:227651	78/314 (25%)
asap2	XP_002935078.3	BAR_ASAP2	34..248	CDD:153326
		PH_ASAP	297..403	CDD:270071
		ArfGap_ASAP2	419..541	CDD:350074	45/128 (35%)
		ANKYR	498..676	CDD:223738	38/186 (20%)
		ANK repeat	550..582	CDD:293786	6/32 (19%)
		ANK repeat	585..618	CDD:293786	5/32 (16%)
		ANK repeat	620..651	CDD:293786	5/30 (17%)
		PHA02682	<902..>980	CDD:177464	13/50 (26%)
		SH3_ASAP2	967..1022	CDD:212899
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910