DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgi and gpib

DIOPT Version :9

Sequence 1:	NP_523663.1	Gene:	Pgi / 35886	FlyBaseID:	FBgn0003074	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_658910.2	Gene:	gpib / 246095	ZFINID:	ZDB-GENE-020513-3	Length:	553	Species:	Danio rerio

Alignment Length:	551	Identity:	377/551 - (68%)
Similarity:	445/551 - (80%)	Gaps:	2/551 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LNQEAAFQKLQEYYDSKGKDLNIKDLFVKDSKRFSKYSLRLHTQNDGEILLDYSKNRINDEVWDL 72
            |..:..||.|:::|.|...:||::.:|.:|..||.|:||.|.| ::|:||||||||.||:||..:
Zfish     3 LTSDPNFQNLEKWYKSNAANLNMRQMFEEDKTRFQKFSLTLKT-DEGDILLDYSKNLINEEVMKM 66

  Fly    73 LLTLAKVRRVNAARDAMFSGQHINITENRAVLHTALRNRGTDPVLVDDKDVMPDVRAELAHMKEF 137
            |:.|||.|.|.|:||.||||:.||.||.|||||.|||||...|:.||.|||||:|...|..||.|
Zfish    67 LVELAKSRGVEASRDKMFSGEKINFTEGRAVLHVALRNRSNTPIHVDGKDVMPEVNKVLEKMKGF 131

  Fly   138 TNMVISGVWRGCTGKQITDVVNIGIGGSDLGPLMVTEALKPYGK-GLHSHFVSNIDGTHLAEVLK 201
            .:.|.||.|:|.|||.||||||:|||||||||||||||||||.| |....|||||||||:|:.|.
Zfish   132 CHKVRSGEWKGFTGKSITDVVNVGIGGSDLGPLMVTEALKPYSKGGPRVWFVSNIDGTHIAKTLA 196

  Fly   202 KVNYETTLFIVASKTFTTQETITNATSAKTWLLEHSKEPESVAKHFVALSTNKEKVTEFGIDSTN 266
            ::|.||||||:||||||||||||||.|||.|.|:.:|:..:|||||||||||..||.:||||..|
Zfish   197 ELNAETTLFIIASKTFTTQETITNAESAKEWFLQAAKDASAVAKHFVALSTNGPKVKDFGIDPEN 261

  Fly   267 MFGFWDWVGGRYSLWSAIGLSICLSIGFENFEQLLDGAHFMDNHFKTTPFEKNAPVILALLGVWY 331
            ||.|||||||||||||||||||.|.||:||||:||.|||:||.||:|.|.::|||::|||||:||
Zfish   262 MFEFWDWVGGRYSLWSAIGLSIALHIGYENFEKLLSGAHWMDTHFRTAPVDQNAPMLLALLGIWY 326

  Fly   332 SNFFKAETHALLPYDQYLHRFAAYFQQGDMESNGKFVSKSGKPVKYSTGPIVWGEPGTNGQHAFY 396
            .|||:||||.|||||||:|||||||||||||||||:::..|..|.|.||||||||||||||||||
Zfish   327 INFFQAETHCLLPYDQYMHRFAAYFQQGDMESNGKYITTKGTRVNYHTGPIVWGEPGTNGQHAFY 391

  Fly   397 QLIHQGTRLIPCDFIAPAQTHNPIAGGKHHKILLSNFLAQTEALMAGKTVDEARTELSKAGLCGN 461
            ||||||||::|.||:.||||.:||....||||||:||||||||||.|||.:||:.||...||.|:
Zfish   392 QLIHQGTRMVPADFLIPAQTQHPIRNSLHHKILLANFLAQTEALMKGKTTEEAKKELEAGGLSGD 456

  Fly   462 ELDNLLPHKVFVGNRPTNSIVVKKVSPFTLGALIALYEHKIFVQGIIWDINSFDQWGVELGKQLA 526
            .|:.:||||||.||:||||||.||:||||||.|||:||||||:||::|:||||||||||||||||
Zfish   457 NLEKILPHKVFQGNKPTNSIVFKKLSPFTLGVLIAMYEHKIFIQGVMWEINSFDQWGVELGKQLA 521

  Fly   527 KAIEPELDHCNEVSTHDSSTNGLINFIKANW 557
            |.|||||....:||:|||||||||||:|.|:
Zfish   522 KKIEPELQDSAQVSSHDSSTNGLINFLKNNF 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgi	NP_523663.1	pgi	7..556	CDD:234679	376/548 (69%)
		SIS_PGI_1	128..290	CDD:240146	116/162 (72%)
		SIS_PGI_2	338..529	CDD:240147	143/190 (75%)
gpib	NP_658910.2	pgi	1..549	CDD:234679	375/546 (69%)
		SIS_PGI_1	122..285	CDD:240146	116/162 (72%)
		SIS_PGI_2	333..524	CDD:240147	143/190 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595981
Domainoid	1	1.000	728	1.000	Domainoid score	I106
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H145
Inparanoid	1	1.050	780	1.000	Inparanoid score	I508
OMA	1	1.010	-	-		QHG54138
OrthoDB	1	1.010	-	-		D181898at33208
OrthoFinder	1	1.000	-	-		FOG0003701
OrthoInspector	1	1.000	-	-		otm24415
orthoMCL	1	0.900	-	-		OOG6_100716
Panther	1	1.100	-	-	O	PTHR11469
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R466
SonicParanoid	1	1.000	-	-		X2569
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940