DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30349 and UTP5

DIOPT Version :9

Sequence 1:	NP_610421.1	Gene:	CG30349 / 35885	FlyBaseID:	FBgn0050349	Length:	620	Species:	Drosophila melanogaster
Sequence 2:	NP_010686.1	Gene:	UTP5 / 852007	SGDID:	S000002806	Length:	643	Species:	Saccharomyces cerevisiae

Alignment Length:	697	Identity:	155/697 - (22%)
Similarity:	279/697 - (40%)	Gaps:	152/697 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLGKKHVLGFSPNGGQLFASVDESGVLRIWNTETNTLYQEFTPNLQLSGSCTALTWVLVAGSRP 65
            ::|.|:.|      |.|.......|||..:||  .|.||.|   :.:|..:|  |.||.:|.|
Yeast    22 VALDKQRV------GVQPTQRATSSGVDTVWN--ENFLYLE---DSKLKVTC--LKWVNLASS-- 71

  Fly    66 KKSRKSLQAQDAAGDQLHIALGTYKGSVVIYSLAEGKIS-RTLSGDSHDGPVTSITNDNAGH-LY 128
                          |.:.|.||...|.:.:||:...::: :..:|:|::  :..|  |..|: |:
Yeast    72 --------------DTVAIILGMNNGEIWLYSVLANEVTYKFTTGNSYE--IKDI--DLMGNQLW 118

  Fly   129 TVGADCRVVVWSLTDERSIAEWQVGPEKPQNIVYLQK---------SGTLAIGYRQLKVYDIKTK 184
            .:.:......:.|...:.:..:::     .|.|.|.|         ...|.:....:.:.||:.|
Yeast   119 CIDSSDAFYQFDLLQFKLLQHFRI-----NNCVQLNKLTIVPAGDSVAQLLVASHSISLIDIEEK 178

  Fly   185 ELVETFTGHSGEINTISSVASTDGTEFVLTTAKMERVICFWKIDKKGKNKASACTLLME-DLAYC 248
            ::|.||.||...::|:..:.:    ||.::.|:.:|.:..:.| ..|..|   |.|:.| |:
Yeast   179 KVVMTFPGHVSPVSTLQVITN----EFFISGAEGDRFLNVYDI-HSGMTK---CVLVAESDI--- 232

  Fly   249 LTSEVRDDGQL-RVASVTRNGIIHIYLLNVNSLSAE----KFVKPKVSLQIVSDGAETV------ 302
              .|:...||. .:|..|.:|.:.|::..:.|.|.:    |..|....:||||.....|
Yeast   233 --KELSHSGQADSIAVTTEDGSLEIFVDPLVSSSTKKRGNKSKKSSKKIQIVSKDGRKVPIYNAF 295

  Fly   303 --EPLLAVAAHFVTDSNRSHEILFGYGSRQQLQFERFTPNYGEKLNVIVRADPKKLYAKKKGKEQ 365
              :.||.|:  ::.::...:        .:.||:......|..::::......|.......||:.
Yeast   296 INKDLLNVS--WLQNATMPY--------FKNLQWREIPNEYTVEISLNWNNKNKSADRDLHGKDL 350

  Fly   366 PGYQAATKVQKPIVNQKNVEY---------NSALPISQKKVQ----NEVPMEA---RLEH---LK 411
            .......:....:.:..|.::         .....:.|::.:    ||:..|.   :||.   .:
Yeast   351 ASATNYVEGNARVTSGDNFKHVDDAIKSWERELTSLEQEQAKPPQANELLTETFGDKLESSTVAR 415

  Fly   412 IQG--TKLSGGKLLTQSK----TQLLMQALHSKDQAMIQAVLSTQDPETIQLTLDRLPLDYVNPL 470
            |.|  |.|.|..|.|.:.    |.:|.|||.|.|.::::.||:.:|...|:.|:.||     .|
Yeast   416 ISGKKTNLKGSNLKTATTTGTVTVILSQALQSNDHSLLETVLNNRDERVIRDTIFRL-----KP- 474

  Fly   471 VNELSILLQGKHAS--VRSALR------WLHALTSTHTSVLMSEDKEALREKLAVCLGVAEQRMH 527
              .|:::|..:.|.  .|...|      |:......|...|:|...  |...|:......::|..
Yeast   475 --ALAVILLERLAERIARQTHRQGPLNVWVKWCLIIHGGYLVSIPN--LMSTLSSLHSTLKRRSD 535

  Fly   528 CLSEALQITGRVNLIINQMK----RNADNHLNDNKALILDEDPDEPDPEAETNWSDLEEDQPGSP 588
            .|...|.:..|::..||:.|    ...|.|.::.   :::||.|:.:...|.:.:.|.||...|.
Yeast   536 LLPRLLALDARLDCTINKFKTLNYEAGDIHSSEP---VVEEDEDDVEYNEELDDAGLIEDGEESY 597

  Fly   589 KSPLEDELVADDD-------------LATD--DGNADADTDSDVSMD 620
            .|..|:|..:|::             |.|:  ||..:|.. |||.|:
Yeast   598 GSEEEEEGDSDNEEEQKHTSSKQDGRLETEQSDGEEEAGY-SDVEME 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30349	NP_610421.1	WD40	<7..237	CDD:225201	54/240 (23%)
		WD40 repeat	7..50	CDD:293791	13/42 (31%)
		WD40	11..>230	CDD:295369	51/229 (22%)
		WD40 repeat	72..108	CDD:293791	7/36 (19%)
		WD40 repeat	117..151	CDD:293791	5/34 (15%)
		WD40 repeat	159..191	CDD:293791	10/40 (25%)
		WD40 repeat	200..241	CDD:293791	8/40 (20%)
		WD40 repeat	248..273	CDD:293791	6/25 (24%)
		Utp12	439..534	CDD:281932	22/102 (22%)
UTP5	NP_010686.1	WD40	3..256	CDD:421866	66/284 (23%)
		WD40 repeat	60..102	CDD:293791	13/59 (22%)
		WD40 repeat	108..143	CDD:293791	5/41 (12%)
		WD40 repeat	148..185	CDD:293791	8/36 (22%)
		WD40 repeat	192..231	CDD:293791	11/46 (24%)
		Utp12	448..548	CDD:397900	24/109 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4547
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38810
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55826
OrthoFinder	1	1.000	-	-		FOG0002889
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102917
Panther	1	1.100	-	-	LDO	PTHR44267
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1622
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.900