Protein Alignment CG30349 and Wdr43

DIOPT Version :10

• Sequence 1: NP_610421.1
• Gene: CG30349 / 35885
• FlyBaseID: FBgn0050349
• Length: 620
• Species: Drosophila melanogaster
• Sequence 2: NP_783570.1
• Gene: Wdr43 / 72515
• MGIID: 1919765
• Length: 677
• Species: Mus musculus
• Alignment Length: 686
• Identity: 178/686 - (25%)
• Similarity: 309/686 - (45%)
• Gaps: 115/686 - (16%)

  Fly    11 FSPNGGQLFASVDESGVLRIWNTETNTLYQEFTPNLQLSGSCTALTW----VLVAGSRPKKSRKS 71
            |||:....||.....|.||:|.|..|.|:||:.|:..|||:||.|.|    :....|..:|.|||
Mouse    21 FSPDSQAYFALASSDGQLRVWETANNRLHQEYVPSAHLSGTCTCLAWAPARLQAKESHQRKKRKS 85

  Fly    72 LQAQDAAG--DQLH-IALGTYKGSVVIYSLAEGKISRTLSGDSHDGPVTSIT--NDNAGHLYTVG 131
                :..|  ||.. :||||..||:::||...|::...|:...|:..|..|.  .||
Mouse    86 ----EVTGTKDQADLLALGTAVGSILLYSTVRGELHSKLTSGGHENRVNCIQWHQDN-------- 138

  Fly   132 ADCRVVVWSLTDERSIAEWQV----------GPEKPQNIVYLQKSGTLAIGY-RQLKVYDIKTKE 185
             ||   ::|.:|::.|.||..          |.....:.:.:...|.:.:.. |.:|::.::|||
Mouse   139 -DC---LYSCSDDKYIVEWSTQTCKVKCKWKGDNSSVSSLCISPDGKMLLSAGRTIKLWVLETKE 199

  Fly   186 LVETFTGHSGEINTI-------SSVASTDGTE--FVLTTAKMERVICFWKIDKKGKNKAS--ACT 239
            :...||||:..::::       :....:||..  :.|:.|..:|::..|::..:.|.|::  :.|
Mouse   200 VYRHFTGHATPVSSLRFTTIRPNESQPSDGITGLYFLSGAVHDRLLNVWQVRSENKEKSAVMSFT 264

  Fly   240 LLMEDLAYCLTSEVRDDGQLRVASVTRNGIIHIY--LLNVNSLSAEKFVKPKVSLQIVSDG---A 299
            :..|.:...||.....:..:::|.|.|:|.:|::  :||.:   .:|.:....::||.:.|   .
Mouse   265 VTDEPVYVDLTLSENKEEPVKLAVVCRDGQVHLFEHILNGH---CKKPLTSNCTIQIATPGKGKK 326

  Fly   300 ETVEPLLAVAAHFVTDSNRSHEILFGYGSRQQLQFERFTPNYGEKLNVIVRADPKKLYAKKKGKE 364
            .|.:|:..:||.|..|   ...:|..||:..|...||...| .:..::.:..|....:|
Mouse   327 VTPKPIPILAASFCLD---KMSLLLVYGNWFQPTIERVALN-SKDTHICLERDISNCWA------ 381

  Fly   365 QPGYQAA-TKVQKPIVNQK------NVEYNSA---LPISQ-KKVQN-------EVPMEARLEHLK 411
             |..:.| |||:.|::|.:      .:..:.|   ||.:| |:.:|       |..:|.||..:.
Mouse   382 -PTVETAITKVKTPVMNSEAKVLVPGIPGHHAPIKLPPAQPKEAENKRKLGSTEATIEERLGAMD 445

  Fly   412 I--QGTKLSGGKLLTQSKTQLLMQALHSKDQAMIQAVLSTQDPETIQLTLDRLPLDYVNPLVNEL 474
            :  :|.|   ..|.|.|...||.|.|.|.|..::..||.|::...|:.|:.|:||..|.||:.||
Mouse   446 LDRKGRK---DDLQTNSFAVLLTQGLESNDFEILNKVLQTKNVNLIKRTVLRIPLRVVIPLLQEL 507

  Fly   475 SILLQGKHASVRSALRWLHALTSTHTSVLMSEDKEALREKLAVCLGVAEQRMHCLSEALQITGRV 539
            :..|||...|....::||..:.:.|.|.|.:  ...|.|:|.....:.|.|:....:...:.|::
Mouse   508 TKRLQGHPNSAALMIQWLKCVLTIHASYLST--LPDLVEQLGTLYQLMESRVKTFQKLSNLHGKL 570

  Fly   540 NLIINQM----KRNADNHLNDNKALILDEDPDE-------PDPEAETNW-----SDLEEDQPGSP 588
            .|::.|:    |............|:.:|:..|       |:.:::.||     .|.|:|:....
Mouse   571 ILLVTQVTASEKSKKMTSPGQKAKLVYEEESSEEESDDEVPEKDSDDNWDEDEDKDSEKDEGVDE 635

  Fly   589 KSPLEDELVADDDLATDDG--------NADADTDSD 616
            .:..|||.:.|.:...:|.        |.|:|.|.:
Mouse   636 DNEEEDEDMEDKEENEEDREVSSEKELNGDSDLDPE 671

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30349	NP_610421.1	WD40 repeat	7..50	CDD:293791	16/38 (42%)
		WD40	<11..228	CDD:441893	69/245 (28%)
		WD40 repeat	72..108	CDD:293791	12/38 (32%)
		WD40 repeat	117..151	CDD:293791	9/35 (26%)
		WD40 repeat	159..191	CDD:293791	6/32 (19%)
		WD40 repeat	200..241	CDD:293791	9/51 (18%)
		WD40 repeat	248..273	CDD:293791	7/24 (29%)
		Utp12	439..544	CDD:461125	30/104 (29%)
Wdr43	NP_783570.1	WD 1	13..51		12/29 (41%)
		WD40 repeat	19..57	CDD:293791	15/35 (43%)
		WD40	<20..305	CDD:441893	82/299 (27%)
		WD 2	57..119		24/65 (37%)
		WD40 repeat	63..124	CDD:293791	21/64 (33%)
		WD 3	124..163		12/50 (24%)
		WD40 repeat	129..165	CDD:293791	11/47 (23%)
		WD 4	166..205		7/38 (18%)
		WD40 repeat	172..205	CDD:293791	6/32 (19%)
		WD 5	207..258		8/50 (16%)
		WD40 repeat	211..261	CDD:293791	8/49 (16%)
		WD 6	266..308		10/44 (23%)
		WD40 repeat	270..319	CDD:293791	11/51 (22%)
		Utp12	471..573	CDD:461125	29/103 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	581..677		19/91 (21%)