DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30349 and wdr43

DIOPT Version :9

Sequence 1:	NP_610421.1	Gene:	CG30349 / 35885	FlyBaseID:	FBgn0050349	Length:	620	Species:	Drosophila melanogaster
Sequence 2:	XP_002938471.4	Gene:	wdr43 / 100379767	XenbaseID:	XB-GENE-991559	Length:	665	Species:	Xenopus tropicalis

Alignment Length:	661	Identity:	186/661 - (28%)
Similarity:	318/661 - (48%)	Gaps:	77/661 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 FSPNGGQLFASVDESGVLRIWNTETNTLYQEFTPNLQLSGSCTALTWVLVAGSRP------KKSR 69
            |||.|..|.|.....|.:::|:|::..|.:|:.|:..||.:||.|.|   |..||      ||.|
Frog    17 FSPRGRDLLALAGADGRIQVWDTQSGALRREYVPSAHLSATCTCLAW---AQGRPDKETHQKKKR 78

  Fly    70 KSLQAQDAAGDQLHIALGTYKGSVVIYSLAEGKISRTLSGDSHDGPVTSIT-NDNAGHLYTVGAD 133
            || :|.|..|:...:.:||..|::::||:|:|::...|.| .||..|..:. :..:..||:...|
Frog    79 KS-EAADRDGNYDLLTIGTATGTILLYSIAKGELQSQLVG-GHDSRVNCVRWHHESASLYSCSED 141

  Fly   134 CRVVVWSLTDERSIAEWQVGPEKPQNIVYLQKSGTLAIGY-RQLKVYDIKTKELVETFTGHSGEI 197
            ..::.|:....:...:|: |.....:.:.:...|.:.:.. |.:|::|::|||:...|||||..:
Frog   142 KHIIEWNTQTCKVKCKWK-GDSSSVSSLCISPDGKMLLSAGRTIKLWDLETKEVYRQFTGHSTAV 205

  Fly   198 NTI---------SSVASTDGTEFVLTTAKMERVICFWKI--DKKGKNKASACTLLMEDLAYCLTS 251
            .::         ..|..|.|..| |:.|..:|:|..|::  :||.|:...:.||....:...|::
Frog   206 TSLLFLTVQPPREPVPDTTGLYF-LSGAVHDRLISVWQVRSEKKDKSSVLSFTLTEPPVFMDLSA 269

  Fly   252 EVRDDGQLRVASVTRNGIIHIYLLNVNSLSAEKFVKPKVSLQIVSDGAE--TVEPLLAVAAHFVT 314
            ....:..|::|.|:|:|.:|::...:|. :.:|.:.|..::||.:.|:|  |.:|:..:||.|..
Frog   270 PESKEEPLKLAVVSRDGHLHLFEHVLNG-THKKPIAPTCTVQIATSGSESATPKPVPILAASFCA 333

  Fly   315 DSNRSHEILFGYGSRQQLQFERFTPNYGEKLNVIVRADPKKLYAKKKGKEQPGYQAATKVQKPIV 379
            |  |...:|| |||..|...|:......|. |:.:..|.:|..|.:  |:.|    .|||:.|:|
Frog   334 D--RQSLLLF-YGSTLQPIIEKVALKTDEP-NICLIRDIQKTVALR--KDAP----VTKVKTPVV 388

  Fly   380 NQKNVEYNSALP---------ISQKKVQN--------EVPMEARLEHLKIQGTKLSGGKLLTQSK 427
            |..:......:|         ::|.|.|.        |..:|.||..:.|...|..|...|.|:.
Frog   389 NSDSKVLTPGIPGHSSAISAAMAQTKKQESKRKPGDIEASIEDRLGAMDIDTGKAPGKGALPQTD 453

  Fly   428 --TQLLMQALHSKDQAMIQAVLSTQDPETIQLTLDRLPLDYVNPLVNELSILLQGKHASVRSALR 490
              ..||:|.|.|.|..::..|..|:....|:.|:.|:|:..|.|||:||:..|||...|....:|
Frog   454 NFAVLLVQGLESNDSNILNKVFQTKSDSIIRKTVARIPVYAVIPLVHELTKRLQGHPLSAVQMVR 518

  Fly   491 WLHALTSTHTSVLMSEDKEALREKLAVCLGVAEQRMHCLSEALQITGRVNLIINQM---KRNADN 552
            ||.|:...|.|.|.:  ...|..:|.:...:.|.|:..|.:..::.|::.|:|.|:   :|....
Frog   519 WLKAVLVLHASYLST--LPDLVPQLGMLYQLMENRVKNLHKLSRLNGKLYLLITQVTAAERVQRT 581

  Fly   553 HLNDNKALILDED-PDEPDPEAE-----TNWS-----DLEEDQ-PGSPK--SPLEDELVADDDLA 603
            .|:....|:.:|: .:|.|.|.:     .:||     |:||:: .|..|  ...|:|....:|::
Frog   582 ELDQEAKLVYEEESSEESDEERQGEQESEDWSEGEEEDMEEEEGEGQDKEAETSEEEESDAEDMS 646

  Fly   604 TDDGNADADTD 614
            ....|.|:|.|
Frog   647 VGKVNGDSDPD 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30349	NP_610421.1	WD40	<7..237	CDD:225201	71/244 (29%)
		WD40 repeat	7..50	CDD:293791	13/38 (34%)
		WD40	11..>230	CDD:295369	68/237 (29%)
		WD40 repeat	72..108	CDD:293791	10/35 (29%)
		WD40 repeat	117..151	CDD:293791	4/34 (12%)
		WD40 repeat	159..191	CDD:293791	7/32 (22%)
		WD40 repeat	200..241	CDD:293791	13/51 (25%)
		WD40 repeat	248..273	CDD:293791	7/24 (29%)
		Utp12	439..534	CDD:281932	29/94 (31%)
wdr43	XP_002938471.4	WD40	15..251	CDD:421866	70/240 (29%)
		WD40 repeat	15..53	CDD:293791	12/35 (34%)
		WD40 repeat	59..118	CDD:293791	23/63 (37%)
		WD40 repeat	123..159	CDD:293791	5/35 (14%)
		WD40 repeat	166..199	CDD:293791	7/32 (22%)
		WD40 repeat	205..248	CDD:293791	9/43 (21%)
		WD40 repeat	267..296	CDD:293791	7/28 (25%)
		Utp12	466..570	CDD:397900	31/105 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I9415
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H38810
Inparanoid	1	1.050	203	1.000	Inparanoid score	I3646
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1032141at2759
OrthoFinder	1	1.000	-	-		FOG0002889
OrthoInspector	1	1.000	-	-		oto103484
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5756
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060