DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT8 and CCT3

DIOPT Version :9

Sequence 1:	NP_610418.1	Gene:	CCT8 / 35882	FlyBaseID:	FBgn0284436	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_005989.3	Gene:	CCT3 / 7203	HGNCID:	1616	Length:	545	Species:	Homo sapiens

Alignment Length:	551	Identity:	149/551 - (27%)
Similarity:	270/551 - (49%)	Gaps:	37/551 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VSQMLK--DGARMYSGLEEAVFRNISACKEFAQTMRSAYGPNGMNKMIINHIEKQFVTSDAGTIM 73
            :||..|  .|.::.||       ||:|.|..|..:|:..||..|.||:::.:....:|:|...|:
Human    10 LSQNTKRESGRKVQSG-------NINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAIL 67

  Fly    74 RELDVEHPAAKLIVMASQMQDAEVGDGTNFVVVLAGALLESAEELLRLGITTAEISDGYEKALEK 138
            ||:.|:|||||.::..|:.||.||||||..|::|||.:|..||..|...:....:...|.|||:.
Human    68 REIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRKALDD 132

  Fly   139 ALEILPNLVSHKIE---DYRNVEKVKEVLRTSIMSKQYGQEDFLNDLVSKACVSIL--PDEGTFN 198
            .:..|     .||.   |..:.:.:..::.:||.:|...:...|...::...|.::  .:.|...
Human   133 MISTL-----KKISIPVDISDSDMMLNIINSSITTKAISRWSSLACNIALDAVKMVQFEENGRKE 192

  Fly   199 VD---NIRICKILGSGLTKSEVVRGMVFKRFVEGDVT------YAEKAKIVIFSCPVDIIQTETK 254
            :|   ..|:.||.|..:..|.|:||::..:    |||      |.:..:||:....::..:.|::
Human   193 IDIKKYARVEKIPGGIIEDSCVLRGVMINK----DVTHPRMRRYIKNPRIVLLDSSLEYKKGESQ 253

  Fly   255 GTVLIKSADELLSFSSGEESLLESQIKAIADAGVKVVVAGGKVGDMALHFLNKYGLMAVRLNSKF 319
            ..:.|...::.......||..::...:.|......||:....:.|:|.|:|.:..:.|:|...|.
Human   254 TDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLAQHYLMRANITAIRRVRKT 318

  Fly   320 DLRRLSRSVNATVLPRITTPSQEELGY-CDKVCIEELGDTTIVAFRNEGKDSRIATVVIRGATDN 383
            |..|::|:..|.::.|.....::::|. ...:.|:::|| ....|..:.||.:..|:::|||:..
Human   319 DNNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGD-EYFTFITDCKDPKACTILLRGASKE 382

  Fly   384 FMDDIERALDDAINNFKCLTRDGRYLPGAGATEIELATQLSAYADTLPGLDQYAVRKFANALEVF 448
            .:.::||.|.||:...:.:..|.:.:||.||:|:.:|..|:..:..:.|::|:..|..|.||||.
Human   383 ILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVI 447

  Fly   449 PKALAENSGINGTEIVNQLYLAHNNEAGKTIGFDIEAEKASTIDTTKAKLFDLYQSKFWGLKYAV 513
            |:.|.:|.|.:...::..|...|..|..:|.|  :..|..:.:|..:..:::....|....|.||
Human   448 PRTLIQNCGASTIRLLTSLRAKHTQENCETWG--VNGETGTLVDMKELGIWEPLAVKLQTYKTAV 510

  Fly   514 GAAATILKVDQIIMA-KRAGGPKVRQAAGSD 543
            ..|..:|::|.|:.. |:.|..:.||....|
Human   511 ETAVLLLRIDDIVSGHKKKGDDQSRQGGAPD 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT8	NP_610418.1	TCP1_theta	20..529	CDD:239457	140/524 (27%)
CCT8	NP_610418.1	Cpn60_TCP1	40..529	CDD:278544	134/504 (27%)
CCT3	NP_005989.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		4/13 (31%)
		chap_CCT_gamma	6..529	CDD:274085	145/537 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..545		5/16 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920