DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCT8 and cct4

DIOPT Version :9

Sequence 1:	NP_610418.1	Gene:	CCT8 / 35882	FlyBaseID:	FBgn0284436	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	XP_012818347.1	Gene:	cct4 / 448604	XenbaseID:	XB-GENE-974483	Length:	561	Species:	Xenopus tropicalis

Alignment Length:	483	Identity:	154/483 - (31%)
Similarity:	256/483 - (53%)	Gaps:	19/483 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 FRNISACKEFAQTMRSAYGPNGMNKMIINHIEKQFVTSDAGTIMRELDVEHPAAKLIVMASQMQD 94
            |.||||.|..|..:|::.||.||:|||.:......:|:|..||::.:.|.|||||::|..|:.||
Frog    38 FSNISAGKAVADAVRTSLGPKGMDKMIQDGKGDVTITNDGATILKLMQVLHPAAKMLVELSKAQD 102

  Fly    95 AEVGDGTNFVVVLAGALLESAEELLRLGITTAEISDGYEKALEKALEILPNLVSHKIEDYRNVEK 159
            .|.||||..|||:|||||::..:||:.||....||:.::.|.:|.:|:|.|: |..:| ..:.|.
Frog   103 IEAGDGTTSVVVIAGALLDACAKLLQKGIHPTTISESFQLASDKGIEVLTNM-SQSVE-LSDRET 165

  Fly   160 VKEVLRTSIMSKQYGQ-EDFLNDLVSKACVSILPDEGTFNVD--NIRICKILGSGLTKSEVVRGM 221
            :.....||:.||...| ...|..:...|.:.::..:...:||  :|:|.|.||..:...|:|.|:
Frog   166 LLNSATTSLNSKVVSQYSSLLAPMSVDAVMKVIDPQTANSVDLRDIKIVKKLGGTIDDCEMVDGL 230

  Fly   222 VF-KRFVEGDVTYAEKAKIVIFSCPVDIIQTETKGTVLIKSADELLSFSSGEESLLESQIKAIAD 285
            |. ::.....||..|||||.:....:...:|:....:::....::......|.:.:.:.:|.|..
Frog   231 VLTQKAANTGVTRVEKAKIGLIQFCLSAPKTDMDNQIVVSDYAQMDRVLREERTYILNLVKQIKK 295

  Fly   286 AGVKVV-----VAGGKVGDMALHFLNKYGLMAVRLNSKFDLRRLSRSVNATVLPRITTPSQEELG 345
            ||..|:     :....:.|:|||||||..:|.|:...:.|:..:.:::....:..|...:.:.|.
Frog   296 AGCNVLLIQKSILRDALSDLALHFLNKMKIMVVKDIEREDIEFICKTIGTKPVAHIDQFTADMLA 360

  Fly   346 ---YCDKVCIEELGD-TTIVAFRNEGKDSRIATVVIRGATDNFMDDIERALDDAINNFKCLTRDG 406
               ..::|.:...|. ..|....|.||   ..|:|:||:....:::.||::.||:...:||.:..
Frog   361 SAELAEEVSLNGSGKLVKITGCANPGK---TVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKR 422

  Fly   407 RYLPGAGATEIELATQLSAYADTLPGLDQYAVRKFANALEVFPKALAENSGINGTEIVNQLYLAH 471
            ..:.|.||.||||:.:|:.||.||.|::.|.:|.||:|||:.|..||||:|:|....|.:|...|
Frog   423 ALIAGGGAPEIELSLRLNEYARTLSGMESYCIRAFADALEIIPFTLAENAGLNPISTVTELRNRH 487

  Fly   472 NNEAGKTIGFDIEAEKASTIDTTKAKLF 499
             .:..||.|.::...|:|..|.:...:|
Frog   488 -AQGEKTAGINVRKVKSSIPDCSLLYMF 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT8	NP_610418.1	TCP1_theta	20..529	CDD:239457	154/483 (32%)
CCT8	NP_610418.1	Cpn60_TCP1	40..529	CDD:278544	148/473 (31%)
cct4	XP_012818347.1	TCP1_delta	28..500	CDD:239454	150/467 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010