DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT8 and cct8

DIOPT Version :9

Sequence 1:	NP_610418.1	Gene:	CCT8 / 35882	FlyBaseID:	FBgn0284436	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	XP_005155423.1	Gene:	cct8 / 394037	ZFINID:	ZDB-GENE-040426-876	Length:	558	Species:	Danio rerio

Alignment Length:	551	Identity:	337/551 - (61%)
Similarity:	431/551 - (78%)	Gaps:	7/551 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALSVPKAPGVSQMLKDGARMYSGLEEAVFRNISACKEFAQTMRSAYGPNGMNKMIINHIEKQFV 65
            |||.||||||.:|||||||:.||||||||||||.||||.|||.|:||||||||||:|||:||.||
Zfish     1 MALHVPKAPGFAQMLKDGAKHYSGLEEAVFRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFV 65

  Fly    66 TSDAGTIMRELDVEHPAAKLIVMASQMQDAEVGDGTNFVVVLAGALLESAEELLRLGITTAEISD 130
            |:||.||:|||:|:|||||:|||||.||:.|||||||||:|.||||||.||||||:|::.:|:.:
Zfish    66 TNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRMGLSVSEVIE 130

  Fly   131 GYEKALEKALEILPNLVSHKIEDYRNVEKVKEVLRTSIMSKQYGQEDFLNDLVSKACVSILPDEG 195
            |||.|.:|||||||:.|....::..::|:...::|:::||||||.||||.:|:::|||||.|:.|
Zfish   131 GYEMACKKALEILPDCVCSSAKNLHDLEEATAMIRSAVMSKQYGNEDFLANLIAQACVSIFPESG 195

  Fly   196 TFNVDNIRICKILGSGLTKSEVVRGMVFKRFVEGDVTYAEKAKIVIFSCPVDIIQTETKGTVLIK 260
            :|||||:|:|||||.||..|.::.|||||:..|||||..:.|||.:||||.|...||||||||||
Zfish   196 SFNVDNVRVCKILGCGLNSSTMLHGMVFKKEAEGDVTSVKDAKIAVFSCPFDCTVTETKGTVLIK 260

  Fly   261 SADELLSFSSGEESLLESQIKAIADAGVKVVVAGGKVGDMALHFLNKYGLMAVRLNSKFDLRRLS 325
            :||||::||.|||.|:|:|:|||||:|..|||.||||.|||||:.|||.||.||||||:|||||.
Zfish   261 NADELMNFSKGEEDLMEAQVKAIADSGASVVVTGGKVADMALHYANKYKLMVVRLNSKWDLRRLC 325

  Fly   326 RSVNATVLPRITTPSQEELGYCDKVCIEELGDTTIVAFRNEGKDSRIATVVIRGATDNFMDDIER 390
            ::|.||.|||:|:|:.||:|.||.|.:.|:|||.:|.|:::.:|..|:|:||||:|||.||||||
Zfish   326 KTVGATALPRLTSPTPEEMGRCDSVYLSEVGDTQVVVFKHDKEDGAISTLVIRGSTDNLMDDIER 390

  Fly   391 ALDDAINNFKCLTRDGRYLPGAGATEIELATQLSAYADTLPGLDQYAVRKFANALEVFPKALAEN 455
            |:||.:|.||.|.||.|..|||||||||||..:::|.::.|||:|||::|:|.|.|..|:|||||
Zfish   391 AIDDGVNTFKVLVRDARLCPGAGATEIELAKHITSYGESCPGLEQYAIKKYAEAFEALPRALAEN 455

  Fly   456 SGINGTEIVNQLYLAHNNEAGKTIGFDIEAEKASTIDTTKAKLFDLYQSKFWGLKYAVGAAATIL 520
            ||:.|.|::::||..| :|..|..|||||.|..:..|..:|.:.|.|..|:||:|.|..||.|:|
Zfish   456 SGVKGNELISKLYATH-HEGNKNSGFDIEGEGPAVRDMMEAGILDPYLVKYWGIKLATNAAITVL 519

  Fly   521 KVDQIIMAKRAGGPKVRQAAGS------DDE 545
            :||||||||.|||||..:..|.      |||
Zfish   520 RVDQIIMAKPAGGPKAPKQQGHWDKDGWDDE 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT8	NP_610418.1	TCP1_theta	20..529	CDD:239457	310/508 (61%)
CCT8	NP_610418.1	Cpn60_TCP1	40..529	CDD:278544	294/488 (60%)
cct8	XP_005155423.1	chap_CCT_theta	10..539	CDD:274087	325/529 (61%)
cct8	XP_005155423.1	Cpn60_TCP1	39..528	CDD:278544	294/489 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576473
Domainoid	1	1.000	616	1.000	Domainoid score	I178
eggNOG	1	0.900	-	-		E1_KOG0362
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4802
Inparanoid	1	1.050	691	1.000	Inparanoid score	I671
OMA	1	1.010	-	-		QHG53640
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	1	1.000	-	-		FOG0004632
OrthoInspector	1	1.000	-	-		oto41550
orthoMCL	1	0.900	-	-		OOG6_102087
Panther	1	1.100	-	-	LDO	PTHR11353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1490
SonicParanoid	1	1.000	-	-		X3246
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800