DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCT8 and fab1

DIOPT Version :9

Sequence 1:	NP_610418.1	Gene:	CCT8 / 35882	FlyBaseID:	FBgn0284436	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_611269.1	Gene:	fab1 / 37033	FlyBaseID:	FBgn0028741	Length:	1809	Species:	Drosophila melanogaster

Alignment Length:	347	Identity:	76/347 - (21%)
Similarity:	139/347 - (40%)	Gaps:	83/347 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 ESAEELLRLGITTAEISDGYEKALEKALE-----------ILPNLVSHKIEDYRNVEKVKEVLRT 166
            :||||              .||.||..||           :|.:...|:      .:.:.::||.
  Fly   429 QSAEE--------------KEKELENELENDRCYTTATSKLLASYCEHE------EQLLAQMLRA 473

  Fly   167 SIMSKQYGQEDFLNDLVSKACVSILPDEGTFNVDNIR----ICKILGSGLTKSEVVRGMVFKRFV 227
            ..:.:::  :..|..|.|.|.....|:..:.::.:||    ..|:.|.....|::|.|:.|.:.|
  Fly   474 HNLDQEW--DKVLQMLCSTAANHFKPEHCSNDLMDIRNYVNFKKVPGGRRKDSKIVHGVAFSKNV 536

  Fly   228 --EGDVTYAEKAKIVIFSCPVDIIQTETK----GTVLIKSADELLSFSSGEESLLESQIKAIADA 286
              :...|:....:|::..||:...:.|.|    .|||::           |:..|.:....|...
  Fly   537 AHKDMATHVPFPRILLLQCPIVYERIEGKFVTIETVLLQ-----------EKEYLRNVCARIMSF 590

  Fly   287 GVKVVVAGGKVGDMALHFLNKYGLMAVRLNSKFD-LRRLSRSVNATVL----PRITTPSQEELGY 346
            ...||:....|..:|...|..|.:..| |:.|.. :.||||::...::    ..||.|   :|||
  Fly   591 KPNVVLVHKNVAGIAQDLLRSYEVTLV-LDVKLSVMERLSRTLQCDIVSSIESNITMP---KLGY 651

  Fly   347 CDKVCIEELGDTTIVAFRNEGKDSRIATVVIRGATDNFMDDIER---ALDDAINNFKCLTRDGRY 408
            |:...|......|::.| .:..:.|..|.::||.::..:..::|   ||..|..|::
  Fly   652 CNDFYIRNYNGKTLMFF-EKLTNPRGYTCLLRGGSNAELTRVKRVASALLFARYNWR-------- 707

  Fly   409 LPGAGATEIELATQLSAYADTL 430
                    :|::..|:.:|..|
  Fly   708 --------LEMSFLLNEFAQPL 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT8	NP_610418.1	TCP1_theta	20..529	CDD:239457	76/347 (22%)
CCT8	NP_610418.1	Cpn60_TCP1	40..529	CDD:278544	76/347 (22%)
fab1	NP_611269.1	FYVE_PIKfyve_Fab1	182..243	CDD:277264
		DEP	329..397	CDD:214489
		Fab1_TCP	464..717	CDD:239450	62/286 (22%)
		PIPKc	1413..1797	CDD:295374
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453437
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930