DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT8 and cct3

DIOPT Version :9

Sequence 1:	NP_610418.1	Gene:	CCT8 / 35882	FlyBaseID:	FBgn0284436	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_775357.1	Gene:	cct3 / 192327	ZFINID:	ZDB-GENE-020419-5	Length:	543	Species:	Danio rerio

Alignment Length:	557	Identity:	149/557 - (26%)
Similarity:	269/557 - (48%)	Gaps:	44/557 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VSQMLK--DGARMYSGLEEAVFRNISACKEFAQTMRSAYGPNGMNKMIINHIEKQFVTSDAGTIM 73
            :||.:|  .|.::..|       ||||.|..|..:|:..||..|.||:::.:....:|:|...|:
Zfish     9 LSQNIKRESGRKVQIG-------NISAAKTIADIIRTCLGPRAMMKMLLDPMGGIVMTNDGNAIL 66

  Fly    74 RELDVEHPAAKLIVMASQMQDAEVGDGTNFVVVLAGALLESAEELLRLGITTAEISDGYEKALEK 138
            ||:.|:|||||.::..|:.||.||||||..|::|||.:|..||:.|...:....:...|.:||:.
Zfish    67 REIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEQFLEQQMHPTVVIGAYRQALDD 131

  Fly   139 ALEILPNLVSHKIEDYRNVEKVKEVLRTSIMSKQYGQEDFLNDLVSKACVSILPDEGTFNVDN-- 201
            .|.||.: :|..: |..|.:.:.:::.::|.:|...:...|      ||...|....|..:|.
Zfish   132 MLNILKD-ISTPV-DVSNRDMMLKIINSAINTKALSRWSTL------ACNIALDAVRTVELDENG 188

  Fly   202 ---------IRICKILGSGLTKSEVVRGMVFKRFVEGDVTY------AEKAKIVIFSCPVDIIQT 251
                     .::.|:.|..:..|.|:||::    |..|||:      .:..:||:..|.::..:.
Zfish   189 REEIDIKKYAKVEKVPGGIIEDSCVLRGVM----VNKDVTHPRMRRLIKNPRIVLLDCSLEYKKG 249

  Fly   252 ETKGTVLIKSADELLSFSSGEESLLESQIKAIADAGVKVVVAGGKVGDMALHFLNKYGLMAVRLN 316
            |::..:.|...::.......||..::...:.|......::.....:.|:|.|:|.|..:.|:|..
Zfish   250 ESQTDIEIAREEDFARILQMEEEYVQQICEDIIRLKPDLIFTEKGISDLAQHYLMKANITAIRRI 314

  Fly   317 SKFDLRRLSRSVNATVLPRITTPSQEELGYCDKVC-IEELGDTTIVAFRNEGKDSRIATVVIRGA 380
            .|.|..|::|:..|.:..|....::.::|....:. ::::|| ....|..|.||.:..|:::|||
Zfish   315 RKTDNNRIARACGARIASRTDELTENDVGTGTGLFEVKKIGD-EYFTFVTECKDPKACTILLRGA 378

  Fly   381 TDNFMDDIERALDDAINNFKCLTRDGRYLPGAGATEIELATQLSAYADTLPGLDQYAVRKFANAL 445
            :...:.::||.|.||:...:.:..|...|||.||.|:|::.:|:..:..:.|::|:..|..|.||
Zfish   379 SKEILAEVERNLQDAMQVCRNVLLDPYLLPGGGAVEMEVSHRLTERSRAMTGVEQWPYRAVAQAL 443

  Fly   446 EVFPKALAENSGINGTEIVNQLYLAHNNEAGKTIGFDIEAEKASTIDTTKAKLFDLYQSKFWGLK 510
            ||.|:.|.:|.|.:...::..|...|..|...:.|  :..|..:..|..:..:::....|....|
Zfish   444 EVVPRTLIQNCGASAIRVLTSLRAKHTQEGNSSWG--VNGETGTLADMEQLGIWEPLAVKAQTYK 506

  Fly   511 YAVGAAATILKVDQIIMA--KRAGGPKVRQAAGSDDE 545
            .||..|..:|::|.|:..  |:..|.:...|...|.|
Zfish   507 TAVETAILLLRIDDIVSGHKKKGDGEQTGGAPMEDRE 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT8	NP_610418.1	TCP1_theta	20..529	CDD:239457	140/528 (27%)
CCT8	NP_610418.1	Cpn60_TCP1	40..529	CDD:278544	134/508 (26%)
cct3	NP_775357.1	chap_CCT_gamma	5..528	CDD:274085	144/540 (27%)
cct3	NP_775357.1	TCP1_gamma	5..524	CDD:239453	144/536 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920