DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT8 and cct-3

DIOPT Version :9

Sequence 1:	NP_610418.1	Gene:	CCT8 / 35882	FlyBaseID:	FBgn0284436	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_494218.2	Gene:	cct-3 / 173581	WormBaseID:	WBGene00018782	Length:	543	Species:	Caenorhabditis elegans

Alignment Length:	543	Identity:	145/543 - (26%)
Similarity:	263/543 - (48%)	Gaps:	37/543 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 MLKDGARMYSGLEEAVFRNISACKEFAQTMRSAYGPNGMNKMIINHIEKQFVTSDAGTIMRELDV 78
            :|..|.:..|| .:....||:|||..|..:|::.||..|.||:::.:....:|:|...|:||:.|
Worm    11 VLSQGTKRESG-HQVQIGNINACKTIADVIRTSLGPRAMLKMLMDPMGGIVMTNDGNAILREITV 74

  Fly    79 EHPAAKLIVMASQMQDAEVGDGTNFVVVLAGALLESAEELLRLGITTAEISDGYEKALEKALEIL 143
            :|||||.::..::.||.|.||||..|::|||.::..|:..|........|...|.:|||..::..
Worm    75 KHPAAKSMIEIARTQDEETGDGTTSVIILAGEVMAHAQTYLEQKTHPTLIIKAYRQALEDMIQWS 139

  Fly   144 PNLVSHKI---EDYRNVEKVKEVLRTSIMSKQYGQEDFLNDLVSKACVSILPDE-GTFNVDNIRI 204
            .|..|..:   :|....:.||..|.|.::||..   |...::..:|..:|..:: |...:|..|.
Worm   140 ENKFSKTVDITDDAEIAKVVKSCLGTKMISKWM---DLAVNISIQAVKTIRVEKAGVREIDIKRY 201

  Fly   205 C---KILGSGLTKSEVVRGMVFKRFVEGDVTYA------EKAKIVIFSCPVDIIQTETKGTVLIK 260
            |   ||.|..:..|:||:|:|    |..|:.:|      |..:||:..|.::..:.|::.::.|.
Worm   202 CRIEKIPGGRIEDSQVVKGIV----VNKDILHAKMRRRIENPRIVLLDCNLEYKKGESQTSLEIM 262

  Fly   261 SADELLSFSSGEESLLESQIKAIADAGVKVVVAGGKVGDMALHFLNKYGLMAVRLNSKFDLRRLS 325
            ..:::.:....||..:..|...|......:|.....:.|:|.|||.|.|:..:|...|.|..||:
Worm   263 REEDISAILEQEEQAIRKQCDEIIKLKPDLVFTEKGISDLAQHFLLKAGITCLRRLKKTDNNRLA 327

  Fly   326 RSVNATVLPRITTPSQEELGYCDKVCIEELGDTTIVAFRNE------GKDSRIATVVIRGATDNF 384
            |...|.|:...:....|::|  .|..:.|     :|...:|      .:.:...|||:||.:.:.
Worm   328 RVCGARVVHDTSDLRDEDVG--TKAQLFE-----VVKIADEYYTYVTAETTTACTVVLRGPSKDV 385

  Fly   385 MDDIERALDDAINNFKCLTRDGRYLPGAGATEIELATQLSAYADTLPGLDQYAVRKFANALEVFP 449
            ::::||.|.|:::..:.:..:.:.:||.||.|:.|:.::......:.|:.::..:....||||.|
Worm   386 INEVERNLQDSLHVVRNIMINPKLVPGGGALEMALSREIEQQGAKMDGVKKWPYKAIGLALEVIP 450

  Fly   450 KALAENSGINGTEIVNQLYLAHNNEAGKTIGFDIEAEKASTIDTTKAKLFDLYQSKFWGLKYAVG 514
            :.|.:|.|.:....:.:|...|...| :...|.::......:|..|.:::|....:...||.|:.
Worm   451 RTLIQNCGGSTIRKMTELRAIHAQNA-ENWTFGVDGTSGDLVDMNKLEIWDPLAVRIQVLKTAIE 514

  Fly   515 AAATILKVDQIIMA--KRAGGPK 535
            .:..:|::|.|:..  |..||.|
Worm   515 TSVMLLRIDDIVSGTKKAVGGEK 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT8	NP_610418.1	TCP1_theta	20..529	CDD:239457	139/529 (26%)
CCT8	NP_610418.1	Cpn60_TCP1	40..529	CDD:278544	132/509 (26%)
cct-3	NP_494218.2	chap_CCT_gamma	8..531	CDD:274085	141/535 (26%)
cct-3	NP_494218.2	TCP1_gamma	8..528	CDD:239453	141/532 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920