DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT8 and CCT4

DIOPT Version :9

Sequence 1:	NP_610418.1	Gene:	CCT8 / 35882	FlyBaseID:	FBgn0284436	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_006421.2	Gene:	CCT4 / 10575	HGNCID:	1617	Length:	539	Species:	Homo sapiens

Alignment Length:	517	Identity:	155/517 - (29%)
Similarity:	266/517 - (51%)	Gaps:	35/517 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 FRNISACKEFAQTMRSAYGPNGMNKMIINHIEKQFVTSDAGTIMRELDVEHPAAKLIVMASQMQD 94
            |.||||.|..|..:|::.||.||:|||.:......:|:|..||::::.|.||||:::|..|:.||
Human    35 FSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARMLVELSKAQD 99

  Fly    95 AEVGDGTNFVVVLAGALLESAEELLRLGITTAEISDGYEKALEKALEILPNLVSHKIEDYRNVEK 159
            .|.||||..||::||:||:|..:||:.||....||:.::|||||.:|||.:: |..:| ..:.|.
Human   100 IEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGIEILTDM-SRPVE-LSDRET 162

  Fly   160 VKEVLRTSIMSKQYGQ-EDFLNDLVSKACVSILPDEGTFNVD--NIRICKILGSGLTKSEVVRGM 221
            :.....||:.||...| ...|:.:...|.:.::......:||  :|:|.|.||..:...|:|.|:
Human   163 LLNSATTSLNSKVVSQYSSLLSPMSVNAVMKVIDPATATSVDLRDIKIVKKLGGTIDDCELVEGL 227

  Fly   222 VFKRFVEGD-VTYAEKAKIVIFSCPVDIIQTETKGTVLIKSADELLSFSSGEESLLESQIKAIAD 285
            |..:.|... :|..|||||.:....:...:|:....:::....::......|.:.:.:.:|.|..
Human   228 VLTQKVSNSGITRVEKAKIGLIQFCLSAPKTDMDNQIVVSDYAQMDRVLREERAYILNLVKQIKK 292

  Fly   286 AGVKVV-----VAGGKVGDMALHFLNKYGLMAVRLNSKFDLRRLSRSVNATVLPRITTPSQEELG 345
            .|..|:     :....:.|:|||||||..:|.::...:.|:..:.:::....:..|...:.:.||
Human   293 TGCNVLLIQKSILRDALSDLALHFLNKMKIMVIKDIEREDIEFICKTIGTKPVAHIDQFTADMLG 357

  Fly   346 YCDKVCIEEL---GDTTIVAFRNEGKDSRIATVVIRGATDNFMDDIERALDDAINNFKCLTRDGR 407
            ..:  ..||:   |...::.........:..|:|:||:....:::.||::.||:...:||.:...
Human   358 SAE--LAEEVNLNGSGKLLKITGCASPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRA 420

  Fly   408 YLPGAGATEIELATQLSAYADTLPGLDQYAVRKFANALEVFPKALAENSGINGTEIVNQLYLAHN 472
            .:.|.||.|||||.:|:.|:.||.|::.|.||.||:|:||.|..||||:|:|....|.:|...|
Human   421 LIAGGGAPEIELALRLTEYSRTLSGMESYCVRAFADAMEVIPSTLAENAGLNPISTVTELRNRH- 484

  Fly   473 NEAGKTIGFDIEAEKASTIDTTKAKLFDLYQS--------KFWGLKYAVGAAATILKVDQII 526
                      .:.||.:.|:..|..:.::.:.        ....|..|.....:|||:|.::
Human   485 ----------AQGEKTAGINVRKGGISNILEELVVQPLLVSVSALTLATETVRSILKIDDVV 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT8	NP_610418.1	TCP1_theta	20..529	CDD:239457	155/517 (30%)
CCT8	NP_610418.1	Cpn60_TCP1	40..529	CDD:278544	149/507 (29%)
CCT4	NP_006421.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
CCT4	NP_006421.2	TCP1_delta	25..538	CDD:239454	155/517 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920