DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MrgBP and MRGBP

DIOPT Version :9

Sequence 1:	NP_610417.1	Gene:	MrgBP / 35880	FlyBaseID:	FBgn0033341	Length:	201	Species:	Drosophila melanogaster
Sequence 2:	NP_060740.1	Gene:	MRGBP / 55257	HGNCID:	15866	Length:	204	Species:	Homo sapiens

Alignment Length:	206	Identity:	73/206 - (35%)
Similarity:	108/206 - (52%)	Gaps:	22/206 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AKDKGLAVAGTAAPLPAALDHEWSAEEELQLFHAMEGLRPVGINKHFYMSCIVQRLSKSLNREMP 67
            |.|||   .|.||..||.....||.|.|:.|||||.|.:|||:|:||:|.||..:.|:::.|::|
Human    12 AGDKG---PGEAATSPAEETVVWSPEVEVCLFHAMLGHKPVGVNRHFHMICIRDKFSQNIGRQVP 73

  Fly    68 SELIWRHLGTMYKLKELDDLESLPFPNEEREFSLPEQDYGTLQTKKT-VEVHANEEAAE------ 125
            |::||.||.|||.::.|.:.|.|||||.||.|.|||:....::..|. :|....||..|
Human    74 SKVIWDHLSTMYDMQALHESEILPFPNPERNFVLPEEIIQEVREGKVMIEEEMKEEMKEDVDPHN 138

  Fly   126 -AQSAPPTAETNGKAPPATKTPVPTNSTKDGDKKPVAKPQEQLPKRPAKRTRGSMSNESISPSTT 189
             |.....::.:.|||...:......||:..|.|:..           .||.|..::::.::.::.
Human   139 GADDVFSSSGSLGKASEKSSKDKEKNSSDLGCKEGA-----------DKRKRSRVTDKVLTANSN 192

  Fly   190 PPPVQSNKRRR 200
            |....:.||||
Human   193 PSSPSAAKRRR 203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MrgBP	NP_610417.1	Eaf7	29..106	CDD:285187	40/76 (53%)
MRGBP	NP_060740.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		9/17 (53%)
		Eaf7	36..112	CDD:400315	40/75 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..204		19/87 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155712
Domainoid	1	1.000	71	1.000	Domainoid score	I9502
eggNOG	1	0.900	-	-		E1_KOG4051
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10104
Inparanoid	1	1.050	113	1.000	Inparanoid score	I4854
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1476852at2759
OrthoFinder	1	1.000	-	-		FOG0005866
OrthoInspector	1	1.000	-	-		oto91492
orthoMCL	1	0.900	-	-		OOG6_105343
Panther	1	1.100	-	-	LDO	PTHR13581
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5107
SonicParanoid	1	1.000	-	-		X5633
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790