DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sec31 and Sec31a

DIOPT Version :9

Sequence 1:NP_001286215.1 Gene:Sec31 / 35877 FlyBaseID:FBgn0033339 Length:1260 Species:Drosophila melanogaster
Sequence 2:XP_006250738.1 Gene:Sec31a / 93646 RGDID:620233 Length:1262 Species:Rattus norvegicus


Alignment Length:1362 Identity:460/1362 - (33%)
Similarity:695/1362 - (51%) Gaps:209/1362 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MKIKELQKTVNIAWSPAQQQQILLAAGTAAQQFDS--NANSTLELYSPNFSDATYDLELRASVSS 63
            ||:||:.:|...||||||...|.||.||:|||.|:  :.|::||::..:.||.:.|::..|:.||
  Rat     1 MKLKEIDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLSDPSLDMKSCATFSS 65

  Fly    64 QYKFQKLIWSPVGPHP-------SGLIVGGCEAGQINIYSADKLLAGKEEPLLKRQDKHTGAVSG 121
            .:::.||||   |||.       ||:::.|.|.|.|.:|...|::||.:|.::.::|||||.|..
  Rat    66 SHRYHKLIW---GPHKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGDKEVVIAQKDKHTGPVRA 127

  Fly   122 LDFNPFQNNLLASCASESEILIWDLNNPETSMSPGTKTQPLEDVKNVAWNRQVQHILASVF-STR 185
            ||.|.||.||:||.|:||||.||||||..|.|:||.||||.||:..:||||||||||||.. |.|
  Rat   128 LDVNIFQTNLVASGANESEIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGR 192

  Fly   186 CVIWDLRKSQQIIKLSDSQSRVRWHAIEWHPEAATQVWLASEDDQAPVVQLWDLRYATAPAKTYQ 250
            ..:|||||::.|||:||..:|:....:.|||:.|||:.||||||:.||||:||||:|::|.:..:
  Rat   193 ATVWDLRKNEPIIKVSDHSNRMHCSGLAWHPDVATQMVLASEDDRLPVVQMWDLRFASSPLRVLE 257

  Fly   251 IHERGVLGMSWCLQDNDLMVSCGKDNRIYCWNPNTKIPEGEILSEVATTASWYSDVQFCPRNPAL 315
            .|.||:|.::|.:.|.:|::|||||.:|.|.||||    ||:|.|:.|...|..|:|:||||||:
  Rat   258 NHARGILAIAWSMADPELLLSCGKDAKILCSNPNT----GEVLYELPTNTQWCFDIQWCPRNPAV 318

  Fly   316 IASASLEGAVSIYSLHGGTHHLV--QTANKIADSFPGMDQFAQ-EP-----IPQQATQ-VVYHDL 371
            :::||.:|.:.:||:.||:...:  :..:|::.||..:|.|.. :|     ||||.:| .:...|
  Rat   319 LSAASFDGRIRVYSIMGGSIDGLRQKQVDKLSSSFGNLDPFGTGQPLPPLQIPQQTSQHSIVLPL 383

  Fly   372 AHAPKWMKRPCGVAFGFGGKLVSFNGTS------------KTVKVQQLTTESALVDRANALERSL 424
            ...|||::||.|.:|.||||||:|...:            :.|.:.|:.||...:.|:..|:..:
  Rat   384 KKPPKWIRRPVGASFSFGGKLVTFENVTGQPQQGAEQPRRQPVFISQVVTEKDFLSRSEQLQHVV 448

  Fly   425 VDANYSDYCRQRADETPDQHGRYIWYFIKANFELNPKEEMLNLLGYNKDDIDSKFNKFIKETDGN 489
            ....:..||:::.|.:.....:.:|.|:|.|||.:.:.:.|.||||.::|:..|....:...|| 
  Rat   449 QSQGFISYCQKKIDASQTDFEKNVWSFLKVNFEEDSRGKYLELLGYRREDLGEKIALALNRVDG- 512

  Fly   490 SHSDVDTLTTRISTLTHSDSSEVECDQSTNYSTDNSQTQDNKFDGNAIDSQNHN-DFATPPRPQ- 552
                             ||.:..:.|:......:.|..::.:..|..|..:... ||.    |. 
  Rat   513 -----------------SDVALKDSDRVAQSDGEESPAEEGQLLGERIKEEKQECDFL----PSA 556

  Fly   553 ----FKVPSGDHSDSLIAEAILTGNVDAAVELCLEAQRIPEALIIASTAGIETLNRTQTRYLLQQ 613
                |.:......|.||..|:||||.::||:|||...|:.:|:|:|...|.|.|.:||.:|..:.
  Rat   557 GGGTFNISVSGDIDGLITRALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLAQTQKKYFAKS 621

  Fly   614 KNELSHVISALVSRDWLDFVNRCTVDSWKEALVAALKHSE-RKVVDICERLGDRLLSECASSAEF 677
            :::::.:|:|:|.::|.:.|..|.:.:|:|||.|.|.::: .:...:|:.||.||.||  ..:..
  Rat   622 QSKITRLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGARLESE--GDSLL 684

  Fly   678 TRNAMLCYICAGSIDKLVTAWYQLKRLEQQNPGYKPNTTELQDLAEMVMLMCKSLE-QQGISVDL 741
            ...|.|||||||::::||..|  .|..:..||      ..||||.|.|:::.|::: .|.:..:.
  Rat   685 RTQACLCYICAGNVERLVACW--TKAQDGSNP------LSLQDLIEKVVILRKAVQLTQALDTNT 741

  Fly   742 AGR-FAGFLTEYGGLLASQGALTAALQYITTLGGGAAASESDVLQSLRDRINNAVNLDYTQPQAA 805
            .|. .|..:::|..|||:||::.|||.::..     ..::.|::| ||||:..|..         
  Rat   742 VGALLAEKMSQYANLLAAQGSIAAALAFLPD-----NTNQPDIVQ-LRDRLCRAQG--------- 791

  Fly   806 VAAAPHGYQPTRGRGSFSQPQPSAPMPYGQPPNQYAQPSWPAQVPPLQTS--YPGAQQPQAPPQI 868
                    :...|:.|........|:|.|.|......|    ||..:|:.  ||   |.:..|.:
  Rat   792 --------RSVPGQESSRSSYEGQPLPKGGPGPLAGHP----QVSRVQSQQYYP---QVRIAPTV 841

  Fly   869 FNPQPVKPEPL-AQPPRPLSNASSSGGPPPAGGASSSGGSGLSGRSKYVLDPSVAAPTSSYGMPY 932
            .......|..| :.||....:.:..|.|||.|               :::..:| .|.|...:|.
  Rat   842 TTWSDRTPTALPSHPPAACPSDTQGGNPPPPG---------------FIMHGNV-VPNSPAPLPT 890

  Fly   933 NP-----VPAPVPSAVPF----------GGGGVPGPAPQPASVPTYNS--NAFNTNPIAA----- 975
            :|     .|.|.|...|:          ||..|..| .||.:.|..|:  ||...:|:|:     
  Rat   891 SPGHMHSQPPPYPQPQPYQPAQQYSFGTGGSAVYRP-QQPVAPPASNAYPNAPYVSPVASYSGQP 954

  Fly   976 ----AQPYN-------PSPLMPAQQNQFV---PGVNPIET---MPP--PAVPPVIQNV---QRNP 1018
                |||.:       |.|..|:....|.   ||..|..:   :||  ...||....:   ||..
  Rat   955 QMYTAQPASSPTSSSAPLPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTPPAASELPASQRTE 1019

  Fly  1019 T------------PPPGWNDPPALKSSRAPKPKPVVEPSAAIFHPLFPV-DPNQNQNGYVDPSQY 1070
            .            |..||||||||  :|.||.|.:.|.    |.|..|: .|..|..|...|...
  Rat  1020 NQSFQDQSSVLEGPQNGWNDPPAL--NRVPKKKKLPEN----FMPPVPITSPIMNPGGDPQPQGL 1078

  Fly  1071 QHAAPLGGVPNTYYNPAAFNNNPQQQQQHQQSYLQPQQP------APGIQQPNWQGQQ-QTIGYT 1128
            |......|..:::   |:|   ||......|.:...|||      .|...:||.:|.. ..||.|
  Rat  1079 QQQPSASGPRSSH---ASF---PQPHLAGGQPFHGIQQPLAQTGMPPSFSKPNTEGAPGAPIGNT 1137

  Fly  1129 EQPAPIQQQRQPAPPKEKPPLPEEYIYLQTVLEELKNRCLGATNDPRTKRKFVDVVKRLENLYDC 1193
            .|    ..|..|.....|.|:|:|::.|:|..|:|..|||.:..||:||||..|..||||.|||.
  Rat  1138 IQ----HVQALPTEKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLECLYDK 1198

  Fly  1194 LRDGKLTPTTVQYLNQIVQYIQISDYANAMEIHTQIAFGTDFAQCAGFMQGLKVLLQSASEL 1255
            |||..|:||.:..|:.|.:.|:..:|:..:.:||.|...::|::.:.||..|||:|..||:|
  Rat  1199 LRDQTLSPTIISGLHSIARSIETRNYSEGLTVHTHIVSTSNFSETSAFMPVLKVVLSQASKL 1260

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sec31NP_001286215.1 WD40 repeat 11..61 CDD:293791 22/51 (43%)
WD40 <35..334 CDD:225201 148/308 (48%)
WD40 repeat 68..114 CDD:293791 18/52 (35%)
WD40 <80..329 CDD:295369 129/249 (52%)
WD40 repeat 119..156 CDD:293791 23/36 (64%)
WD40 repeat 166..202 CDD:293791 22/36 (61%)
WD40 repeat 209..250 CDD:293791 22/40 (55%)
WD40 repeat 256..296 CDD:293791 18/39 (46%)
WD40 repeat 303..328 CDD:293791 11/24 (46%)
ACE1-Sec16-like <570..>690 CDD:301350 45/120 (38%)
RCR <811..>873 CDD:304939 14/63 (22%)
Sec31aXP_006250738.1 WD40 repeat 13..65 CDD:293791 22/51 (43%)
WD40 31..405 CDD:225201 175/380 (46%)
WD40 repeat 70..119 CDD:293791 18/51 (35%)
WD40 84..340 CDD:295369 133/259 (51%)
WD40 repeat 125..162 CDD:293791 23/36 (64%)
WD40 repeat 172..208 CDD:293791 22/35 (63%)
WD40 repeat 214..257 CDD:293791 22/42 (52%)
WD40 repeat 263..302 CDD:293791 19/42 (45%)
WD40 repeat 306..331 CDD:293791 11/24 (46%)
ACE1-Sec16-like <573..767 CDD:301350 71/203 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166352677
Domainoid 1 1.000 425 1.000 Domainoid score I592
eggNOG 1 0.900 - - E1_KOG0307
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H42056
Inparanoid 1 1.050 685 1.000 Inparanoid score I678
OMA 1 1.010 - - QHG54150
OrthoDB 1 1.010 - - D100998at2759
OrthoFinder 1 1.000 - - FOG0002042
OrthoInspector 1 1.000 - - otm45377
orthoMCL 1 0.900 - - OOG6_101250
Panther 1 1.100 - - O PTHR13923
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1512
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.770

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