DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sec31 and ANKRD40

DIOPT Version :9

Sequence 1:NP_001286215.1 Gene:Sec31 / 35877 FlyBaseID:FBgn0033339 Length:1260 Species:Drosophila melanogaster
Sequence 2:NP_443087.1 Gene:ANKRD40 / 91369 HGNCID:28233 Length:368 Species:Homo sapiens


Alignment Length:356 Identity:72/356 - (20%)
Similarity:113/356 - (31%) Gaps:114/356 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   701 LKRLEQQNPGYKPNTTELQDLAEMVMLMCKSLEQQGISVDLA-----------------GRFAGF 748
            |::.|||.  .......|.|:.|:     :.|.:.|:.|:..                 |:...:
Human     5 LEQKEQQE--RLREAAALGDIREV-----QKLVESGVDVNSQNEVNGWTCLHWACKRNHGQVVSY 62

  Fly   749 LTEYGG---LLASQGALTAAL---QYITTLGGGAAASESDVLQSLRDRINNAVNLDYTQPQAAVA 807
            |.:.|.   :|.::|.:...|   :.|..:.|.....:.|.......::.....|.:.....|..
Human    63 LLKSGADKEILTTKGEMPVQLTSRREIRKIMGVEEEDDDDDDDDNLPQLKKESELPFVPNYLANP 127

  Fly   808 AAPHGYQPTRGRGSFSQPQPSAP-MPYGQPPNQYAQPSWPAQVPPLQTSYPGAQ---------QP 862
            |.|..|.||  ....:|.|...| .|...||...:.|..|...|||..::|...         ..
Human   128 AFPFIYTPT--AEDSAQMQNGGPSTPPASPPADGSPPLLPPGEPPLLGTFPRDHTSLALVQNGDV 190

  Fly   863 QAPPQIF-NPQPVKPEPLAQPPRPLSNASSSGGPPPAGGASSSGGSGLSGRSKYVLDPSVAAPTS 926
            .||..|. .|:..||.|:.||  |:|.:.|.                                  
Human   191 SAPSAILRTPESTKPGPVCQP--PVSQSRSL---------------------------------- 219

  Fly   927 SYGMPYNPVPAPVPSAVPFGGGGVPGPAPQPASVPTYNSNAFNTNP---IAAAQPYNPSPLMPAQ 988
                 ::.||:..|.::....|...|||  ||..|.:.:.||..|.   :...:..|||    .:
Human   220 -----FSSVPSKPPMSLEPQNGTYAGPA--PAFQPFFFTGAFPFNMQELVLKVRIQNPS----LR 273

  Fly   989 QNQFVP---------------------GVNP 998
            :|.|:.                     ||||
Human   274 ENDFIEIELDRQELTYQELLRVCCCELGVNP 304

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sec31NP_001286215.1 WD40 repeat 11..61 CDD:293791
WD40 <35..334 CDD:225201
WD40 repeat 68..114 CDD:293791
WD40 <80..329 CDD:295369
WD40 repeat 119..156 CDD:293791
WD40 repeat 166..202 CDD:293791
WD40 repeat 209..250 CDD:293791
WD40 repeat 256..296 CDD:293791
WD40 repeat 303..328 CDD:293791
ACE1-Sec16-like <570..>690 CDD:301350
RCR <811..>873 CDD:304939 19/72 (26%)
ANKRD40NP_443087.1 ANK 1 9..38 9/35 (26%)
ANK <14..93 CDD:238125 13/83 (16%)
Ank_4 14..64 CDD:290365 7/54 (13%)
ANK repeat 14..40 CDD:293786 6/30 (20%)
ANK repeat 43..74 CDD:293786 3/30 (10%)
ANK 2 43..72 3/28 (11%)
Ank_2 48..>93 CDD:289560 7/44 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 93..115 2/21 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 139..176 11/36 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 196..238 14/82 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0307
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.