DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec31 and AT1G18830

DIOPT Version :9

Sequence 1:	NP_001286215.1	Gene:	Sec31 / 35877	FlyBaseID:	FBgn0033339	Length:	1260	Species:	Drosophila melanogaster
Sequence 2:	NP_173317.2	Gene:	AT1G18830 / 838464	AraportID:	AT1G18830	Length:	969	Species:	Arabidopsis thaliana

Alignment Length:	1291	Identity:	313/1291 - (24%)
Similarity:	504/1291 - (39%)	Gaps:	377/1291 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IKELQKTVNIAWSPAQQQQILLAAGTAA----QQFDSNANSTLELYSPNFSDATYDLELRASVSS 63
            ||.:.::..:|.:|   :...:||||.|    ..|.|:||  ||::..:|.....:|:|.....|
plant     4 IKSIGRSAFVAIAP---ESPFIAAGTMAGAVDLSFSSSAN--LEIFELDFQSNDRELKLVGQCQS 63

  Fly    64 QYKFQKLIWSPVGPHPSGLIVGGCEAGQINIYSADKLLAGKEEPLLKRQDKHTGAVSGLDFNPFQ 128
            ..:|.:|.|...|....|||.||...|.|.:::.....:| |...::...||.|.|.||:||...
plant    64 SERFNRLAWGSYGSGSDGLIAGGLVDGNIGLWNPISSESG-EIAHVRDLSKHKGPVRGLEFNVKS 127

  Fly   129 NNLLASCASESEILIWDLNNPE--TSMSPGTKTQPLEDVKNVAWNRQVQHILASV-FSTRCVIWD 190
            .|.|||.|.:..:.||||.||.  :....||.:....::.:::||:..||:|||. .:...||||
plant   128 PNQLASGADDGTVCIWDLANPSKPSHYLKGTGSYMQSEISSLSWNKGFQHVLASTSHNGTTVIWD 192

  Fly   191 LRKSQQIIKLSDSQSRVRWHAIEWHPEAATQVWLASEDDQAPVVQLWDLRYATAPAKTYQIHERG 255
            : .:::||  :|.::.||...::|.|:...|:.:||::|.:|.|:|.|:||..:|.:|:..|:||
plant   193 V-NNEKII--TDLKTTVRCSVLQWDPDHFNQILVASDEDSSPNVKLLDIRYLQSPVRTFVGHQRG 254

  Fly   256 VLGMSWCLQDNDLMVSCGKDNRIYCWNPNTKIPEGEILSEVATTASWYSDVQFCPRNPALIASAS 320
            |:.|.||..|:..:::||||||..|||..|    |:|::|:.|..:|..||.:.|:.|.:|:::|
plant   255 VIAMEWCPSDSLYLLTCGKDNRTICWNTKT----GKIVAELPTGQNWNFDVHWYPKMPGVISASS 315

  Fly   321 LEGAVSIYSLHGGTHHLVQTANKIADSFPGMDQFAQEPIPQQATQVVYHDLAH--------APKW 377
            ::|.:.||:|.|.:.:                          .|:...|.|.|        ||||
plant   316 VDGKIGIYNLEGCSSY--------------------------GTENQQHFLFHLLDADPLTAPKW 354

  Fly   378 MKRPCGVAFGFGGKLVSFNGT---SKTVKVQQLTTESALVDRANALERSLVDANYSD---YCRQR 436
            .|||.|.:|||||||:|||..   :..|.:..|.||.:||:|.:..|.:|.:...:.   .|.::
plant   355 WKRPAGASFGFGGKLISFNKNLPEASEVFLHSLATEKSLVNRISKFEAALENGEKTSLRGLCEKK 419

  Fly   437 ADETPDQHGRYIWYFIKANFELNPKEEMLNLLGYNKDDIDSKFNKFIKETDGNSHSDVDTLTTRI 501
            .:|...:..:..|..:                            |.:.|.|||:.      |...
plant   420 TEEAESEEEKETWGLL----------------------------KIMLEEDGNAK------TKLR 450

  Fly   502 STLTHSDSSEVECDQSTN------YSTDNSQTQDNKFDGNAIDSQNHNDFATPPRPQFKVPSGDH 560
            |.|..|..|| |.||:.|      .||:..:||.                ...|..:.:..|...
plant   451 SHLGFSLPSE-ENDQTANEPHATCSSTNVEETQK----------------VPEPEGEEEESSDPT 498

  Fly   561 SDSLIAEAILTGNVDAAVELCLEAQRIPEALIIASTAGIETLNRTQTRYLLQQKNELSHVISALV 625
            .|..|..:::.|:...||..|..|.::.:||:||...|.|....|:.:|:.........|:||::
plant   499 FDDAIQRSLIVGDYKEAVAQCFSANKMADALVIAHVGGTELWESTRDKYIRMSNAPYMKVVSAMM 563

  Fly   626 SRDWLDFVNRCTVDSWKEALVAALKHSE-RKVVDICERLGDRLLSECASSAEFTRNAMLCYICAG 689
            :.|.:.:::.....||||.|......:| .:.:.:|:.|...|:     :|.||..|.|||||||
plant   564 NNDLMTYLHTRQPKSWKETLALICTFAEGDEWISLCDALASNLM-----AAGFTLAATLCYICAG 623

  Fly   690 SIDKLVTAWYQLKRLEQQNPGYKPNTTELQDLAEMVMLMCKSLEQQGISVDLAGRFAGFLTEYGG 754
            ::||.|..|..  .||:|:.| |.....:|||.|..:::..:...:.:|..|...|    ..|..
plant   624 NVDKTVDIWSM--SLEKQSAG-KSYAECVQDLMEKTLVLALTTCNKRVSASLRKLF----ESYAE 681

  Fly   755 LLASQGALTAALQYITTLGGGAAASESDVLQSLRDRINNAVNLDYTQPQAAVAAAPHGYQPTRGR 819
            :|||||.:..|::::..|..|..:.|   |..|||||:.     |.:|:||..:|....||
plant   682 ILASQGLIATAMKFLKLLESGDFSPE---LSILRDRISL-----YAEPEAANTSASTNTQP---- 734

  Fly   820 GSFSQPQPSAPMPYGQPPNQYAQPSWPAQVPPLQTSYPGAQQPQAPPQIFNPQPVKP---EPLAQ 881
                           :..|.|.:.|:                  .|..:.|.||.:.   .|| .
plant   735 ---------------KISNPYQEKSF------------------TPAPLSNAQPSRSITFFPL-N 765

  Fly   882 PPRPLSNASSSGGPPPAGGASSSGGSGLSGRSKYVLDPSVAAPTSSY-------GMPYNPVPAP- 938
            |||.|.||.                             ....||..|       |..||..|.|
plant   766 PPRELKNAD-----------------------------QYQQPTMDYHSFNRSAGPAYNAPPGPG 801

  Fly   939 ----VPSAVPFGGGGVPGPAPQPASVPTYNSNAFNTNPIAAAQPYNPSPLMPAQQNQFVPGVNPI 999
                :.|.|   |..:....||..:.|.                   .|:.|..|         :
plant   802 SYRSIHSQV---GPYINSKIPQTVAPPV-------------------RPMTPTHQ---------V 835

  Fly  1000 ETMPPP-AVPPVIQNVQRNPTPPPGWNDPPALKSSRAPKPKPVVEPSAAIFHPLFPVDPNQNQNG 1063
            ...|.| |.||.:|....:..|               ...||:|.....:|...|
plant   836 AVQPEPVAPPPTVQTADTSNVP---------------AHQKPIVASLTRLFKETF---------- 875

  Fly  1064 YVDPSQYQHAAPLGGVPNTYYNPAAFNNNPQQQQQHQQSYLQPQQPAPGIQQPNWQGQQQTIGYT 1128

plant   876 ----------------------------------------------------------------- 875

  Fly  1129 EQPAPIQQQRQPAPPKEKPPLPEEYIYLQTVLEELKNRCLGATNDPRTKRKFVDVVKRLENLYDC 1193
               .|::...:..|.|::               |.::.|                .::|..|:..
plant   876 ---EPLRGYSRDTPAKKR---------------EAEDNC----------------SRKLGALFSK 906

  Fly  1194 LRDGKLTPTTVQYLNQIVQYIQISDYANAMEIHTQIAFGTDFAQCAGFMQGLKVLL 1249
            |.:|.::....:.|.|:.|.:...|:..|::|. .:...|::.:|:.::..||.::
plant   907 LNNGDISKNAAEKLTQLCQALDKRDFGAALKIQ-GLMTSTEWDECSSWLPTLKKMI 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec31	NP_001286215.1	WD40 repeat	11..61	CDD:293791	16/53 (30%)
		WD40	<35..334	CDD:225201	107/301 (36%)
		WD40 repeat	68..114	CDD:293791	12/45 (27%)
		WD40	<80..329	CDD:295369	91/251 (36%)
		WD40 repeat	119..156	CDD:293791	16/38 (42%)
		WD40 repeat	166..202	CDD:293791	13/36 (36%)
		WD40 repeat	209..250	CDD:293791	14/40 (35%)
		WD40 repeat	256..296	CDD:293791	17/39 (44%)
		WD40 repeat	303..328	CDD:293791	7/24 (29%)
		ACE1-Sec16-like	<570..>690	CDD:301350	36/120 (30%)
		RCR	<811..>873	CDD:304939	7/61 (11%)
AT1G18830	NP_173317.2	WD40 repeat	10..62	CDD:293791	16/56 (29%)
		WD40	32..>326	CDD:225201	106/303 (35%)
		WD40 repeat	68..110	CDD:293791	12/42 (29%)
		WD40	81..326	CDD:295369	92/252 (37%)
		WD40 repeat	118..159	CDD:293791	17/40 (43%)
		WD40 repeat	167..201	CDD:293791	13/36 (36%)
		WD40 repeat	208..249	CDD:293791	14/40 (35%)
		WD40 repeat	255..293	CDD:293791	18/41 (44%)
		WD40 repeat	298..323	CDD:293791	7/24 (29%)
		ACE1-Sec16-like	495..716	CDD:301350	71/235 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	196	1.000	Domainoid score	I902
eggNOG	1	0.900	-	-		E1_KOG0307
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	389	1.000	Inparanoid score	I502
OMA	1	1.010	-	-		QHG54150
OrthoDB	1	1.010	-	-		D100998at2759
OrthoFinder	1	1.000	-	-		FOG0002042
OrthoInspector	1	1.000	-	-		otm3527
orthoMCL	1	0.900	-	-		OOG6_101250
Panther	1	1.100	-	-	O	PTHR13923
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1512
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840