DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec31 and AT3G63460

DIOPT Version :9

Sequence 1:	NP_001286215.1	Gene:	Sec31 / 35877	FlyBaseID:	FBgn0033339	Length:	1260	Species:	Drosophila melanogaster
Sequence 2:	NP_851024.1	Gene:	AT3G63460 / 825521	AraportID:	AT3G63460	Length:	1104	Species:	Arabidopsis thaliana

Alignment Length:	1327	Identity:	365/1327 - (27%)
Similarity:	566/1327 - (42%)	Gaps:	304/1327 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IKELQKTVNIAWSPAQQQQILLAAGTAA----QQFDSNANSTLELYSPNFSDATYDLELRASVSS 63
            ||.:.::.::|.:|   ....:||||.|    ..|.|:||  ||::..:|.....||.|...:.|
plant     4 IKGVGRSASVALAP---DAPYMAAGTMAGAVDLSFSSSAN--LEIFKLDFQSDDRDLPLVGEIPS 63

  Fly    64 QYKFQKLIWSPVGPHPS----GLIVGGCEAGQINIYSADKLLAGK--EEPLLKRQDKHTGAVSGL 122
            ..:|.:|.|...|....    |||.||...|.|::::...|:..:  |..|:.....|.|.|.||
plant    64 SERFNRLAWGRNGSGSEEFALGLIAGGLVDGNIDLWNPLSLIGSQPSENALVGHLSVHKGPVRGL 128

  Fly   123 DFNPFQNNLLASCASESEILIWDLNNP-ETSMSP-----GTKTQPLEDVKNVAWNRQVQHILASV 181
            :||...:|||||.|.:.||.||||..| |.|..|     |:.||  .::..::|||:||.||||.
plant   129 EFNAISSNLLASGADDGEICIWDLLKPSEPSHFPLLKGSGSATQ--GEISFISWNRKVQQILAST 191

  Fly   182 -FSTRCVIWDLRKSQQIIKLSDSQSRVRWHAIEWHPEAATQVWLASEDDQAPVVQLWDLRYATAP 245
             ::...|||||||.:.||..:||..| |...::|:|...||:.:||:||.:|.::|||:|...:|
plant   192 SYNGTTVIWDLRKQKPIINFADSVRR-RCSVLQWNPNVTTQIMVASDDDSSPTLKLWDMRNIMSP 255

  Fly   246 AKTYQIHERGVLGMSWCLQDNDLMVSCGKDNRIYCWNPNTKIPEGEILSEVATTASWYSDVQFCP 310
            .:.:..|:|||:.|.||..|:..:::|.||||..||:.||    .||::|:....:|..||.:.|
plant   256 VREFTGHQRGVIAMEWCPSDSSYLLTCAKDNRTICWDTNT----AEIVAELPAGNNWNFDVHWYP 316

  Fly   311 RNPALIASASLEGAVSIYSLHGGTHHLVQTANKIADSFPGMDQFAQEPIPQQATQVVYHDLAHAP 375
            :.|.:|:::|.:|.:.||::.|.:.:.|:..|           |...|:             .||
plant   317 KIPGVISASSFDGKIGIYNIEGCSRYGVEENN-----------FGTAPL-------------KAP 357

  Fly   376 KWMKRPCGVAFGFGGKLVSFN------GTS---KTVKVQQLTTESALVDRANALERSLVDANYSD 431
            ||.|||.|.:|||||||||.:      |||   ..|.:..|.||.:||.|.:..|.::.:.:.:.
plant   358 KWYKRPVGASFGFGGKLVSCHARAPAKGTSSILSEVFLHSLVTEQSLVSRTSEFEAAIENGDMTS 422

  Fly   432 ---YCRQRADETPDQHGRYIWYFIKANFEL--NPKEEMLNLLGY-----NKDDIDSKFNKFIKET 486
               .|.::::||..:..:..|..:|..||.  ..:.::::.||:     .||          :..
plant   423 LRGLCEKKSEETESEEEKETWGLLKIMFEEEGTSRTKLISHLGFTLPVAEKD----------QAV 477

  Fly   487 DGNSHSDVDTL---TTRISTLTHSDSSEVECDQSTNYSTDNSQTQDNKFDG--------NAID-S 539
            ||.| ||::.:   .|....|...||:|     :..::.||.:...|.|..        :|.| .
plant   478 DGLS-SDLNGIRLEDTAADALDLDDSNE-----AAAFAMDNGEDFFNNFPAKPDTPVSTSAKDFM 536

  Fly   540 QNHNDFATPPRPQFKVPSGDHS------DSLIAEAILTGNVDAAVELCLEAQRIPEALIIASTAG 598
            .:..||:|......::...:..      |:.|..|::.|:...||:.|:.|.::.:||:||...|
plant   537 PSDTDFSTKGEETQEMQEEEEESSDPVFDNAIQRALIVGDYKEAVDQCITANKMADALVIAHVGG 601

  Fly   599 IETLNRTQTRYLLQQKNELSHVISALVSRDWLDFVNRCTVDSWKE--ALVAALKHSERKVVDICE 661
            ......|:.:||.........|:||:|:.|....:...:...|||  ||:......|:... :|:
plant   602 TALWESTREKYLKTSSAPYMKVVSAMVNNDLRSLIYTRSHKFWKETLALLCTFAQGEQWTT-LCD 665

  Fly   662 RLGDRLLSECASSAEFTRNAMLCYICAGSIDKLVTAWYQLKRLEQQNPGYKPNTTELQDLAEMVM 726
            .|..:|:     :|..|..|:|||||||::|:.|..|.:....|:....|   ...||||.|..:
plant   666 ALASKLM-----AAGNTLAAVLCYICAGNVDRTVEIWSRSLANERDGRSY---AELLQDLMEKTL 722

  Fly   727 LMCKSLEQQGISVDLAGRFAGFLTEYGGLLASQGALTAALQYITTLGGGAAASESDVLQSLRDRI 791
            ::..:...:..|..|...|    ..|..:|||||.||.|::|:..|..|..:.|   |..|||||
plant   723 VLALATGNKKFSASLCKLF----ESYAEILASQGLLTTAMKYLKVLDSGGLSPE---LSILRDRI 780

  Fly   792 N-------NAVNLDYTQPQAAVAAAPHGYQPTRGRGSFSQPQPSA-PMPYGQPPNQYAQPSWPAQ 848
            :       |......||||:.:   |:..:||       |.||:. ..||   .|||.||...:.
plant   781 SLSAEPETNTTASGNTQPQSTM---PYNQEPT-------QAQPNVLANPY---DNQYQQPYTDSY 832

  Fly   849 VPPLQTSYPGAQQPQAPPQIFNPQPVKPEPLAQP---PRPLSNASSS------GGPPPAGGASSS 904
            ..| |.|:|..||    |.:|.|...:|.|  ||   |.|.|||..|      ...|||
plant   833 YVP-QVSHPPMQQ----PTMFMPHQAQPAP--QPSFTPAPTSNAQPSMRTTFVPSTPPA------ 884

  Fly   905 GGSGLSGRSKYVLDPSVAAPTSSYGMPYNPVPAPVPSAVPFGGGGVPGPAPQPASVPTYNSNAFN 969
                |....:|                                           ..||.:|::|
plant   885 ----LKNADQY-------------------------------------------QQPTMSSHSF- 901

  Fly   970 TNPIAAAQPYNPSPLMPAQQNQFVP-GVNPIETMPPPAVPPVIQNVQRNPTPPPGWNDPPALKSS 1033
            |.|...|.|..|.|      .|:.| |.:.:...|.|.:|.|:
plant   902 TGPSNNAYPVPPGP------GQYAPSGPSQLGQYPNPKMPQVV---------------------- 938

  Fly  1034 RAPKPKPVVEPSAAIFHPLFPVDPNQNQNGYVDPSQYQHAAPLGGVPNTYYNPAAFNNNPQQQQQ 1098
             ||...|:.      |.|:                    |.|  ||......||    :|..||.
plant   939 -APAAGPIG------FTPM--------------------ATP--GVAPRSVQPA----SPPTQQA 970

  Fly  1099 HQQSYLQPQQPAPGIQQPNWQGQQQTIGYTEQPAPIQQQRQPAPPKEKPPLPEEYIYLQTVLEEL 1163
            ..|:...|..|.|.:|..:...                    .|..:||.:..    |..:..|.
plant   971 AAQAAPAPATPPPTVQTADTSN--------------------VPAHQKPVIAT----LTRLFNET 1011

  Fly  1164 KNRCLGATNDPRTKRKFVDVVKRLENLYDCLRDGKLTPTTVQYLNQIVQYIQISDYANAMEIHTQ 1228
            .....||..:...||:..|..::|..|:..|..|.::......|.|:.|.:..:|::.|::|  |
plant  1012 SEALGGARANTTKKREIEDNSRKLGALFVKLNSGDISKNAADKLAQLCQALDNNDFSTALQI--Q 1074

  Fly  1229 IAFGT-DFAQCAGFMQGLKVLLQSASE 1254
            :...| ::.:|..::..||.::..|.:
plant  1075 VLLTTSEWDECNFWLATLKRMMVKARQ 1101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec31	NP_001286215.1	WD40 repeat	11..61	CDD:293791	17/53 (32%)
		WD40	<35..334	CDD:225201	117/311 (38%)
		WD40 repeat	68..114	CDD:293791	13/51 (25%)
		WD40	<80..329	CDD:295369	101/261 (39%)
		WD40 repeat	119..156	CDD:293791	21/42 (50%)
		WD40 repeat	166..202	CDD:293791	18/36 (50%)
		WD40 repeat	209..250	CDD:293791	14/40 (35%)
		WD40 repeat	256..296	CDD:293791	16/39 (41%)
		WD40 repeat	303..328	CDD:293791	7/24 (29%)
		ACE1-Sec16-like	<570..>690	CDD:301350	36/121 (30%)
		RCR	<811..>873	CDD:304939	21/62 (34%)
AT3G63460	NP_851024.1	WD40 repeat	10..63	CDD:293791	17/57 (30%)
		WD40	32..>337	CDD:225201	117/313 (37%)
		WD40 repeat	68..120	CDD:293791	13/51 (25%)
		WD40	<86..335	CDD:295369	100/255 (39%)
		WD40 repeat	125..168	CDD:293791	21/42 (50%)
		WD40 repeat	176..212	CDD:293791	18/35 (51%)
		WD40 repeat	219..260	CDD:293791	14/40 (35%)
		WD40 repeat	266..293	CDD:293791	12/26 (46%)
		WD40 repeat	309..334	CDD:293791	7/24 (29%)
		ACE1-Sec16-like	<568..784	CDD:301350	71/231 (31%)
		DUF1720	797..871	CDD:285440	34/93 (37%)
		YppG	812..>889	CDD:290883	32/96 (33%)
		RCR	<843..944	CDD:304939	39/189 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	196	1.000	Domainoid score	I902
eggNOG	1	0.900	-	-		E1_KOG0307
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	389	1.000	Inparanoid score	I502
OMA	1	1.010	-	-		QHG54150
OrthoDB	1	1.010	-	-		D100998at2759
OrthoFinder	1	1.000	-	-		FOG0002042
OrthoInspector	1	1.000	-	-		otm3527
orthoMCL	1	0.900	-	-		OOG6_101250
Panther	1	1.100	-	-	LDO	PTHR13923
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1512
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840