DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sec31 and Ankrd40

DIOPT Version :9

Sequence 1:	NP_001286215.1	Gene:	Sec31 / 35877	FlyBaseID:	FBgn0033339	Length:	1260	Species:	Drosophila melanogaster
Sequence 2:	NP_082075.2	Gene:	Ankrd40 / 71452	MGIID:	1918702	Length:	363	Species:	Mus musculus

Alignment Length:	359	Identity:	74/359 - (20%)
Similarity:	112/359 - (31%)	Gaps:	125/359 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   701 LKRLEQQNPGYKPNTTELQDLAEMVMLMCKSLEQQGISVDLA-----------------GRFAGF 748
            |::.|||.  .......|.|:.|:     :.|.:.|:.|:..                 |:...:
Mouse     5 LEQKEQQE--RLREAAALGDIREV-----QKLVESGVDVNSQNEVNGWTCLHWACKRNHGQVVSY 62

  Fly   749 LTEYGG---LLASQGALTAAL---QYITTLGGGAAASESDVLQSLRDRINNAVNLDYTQPQAAVA 807
            |.:.|.   :|.::|.:...|   :.|..:.|...|.|.:.:..|:    ....|.:.....|..
Mouse    63 LLQSGADREILTTKGEMPVQLTSRREIRKIMGVEEADEEEEIPQLK----KESELPFVPNYLANP 123

  Fly   808 AAPHGYQPTRGRGSFSQPQPSAPMPYGQPPNQYAQPSWPAQVPPLQTSYPGA------------- 859
            |.|..|.|  .....:|.|...|.|   ||......|.|..:||.:|...||
Mouse   124 AFPFIYTP--AAEDSTQLQNGGPSP---PPVSPPADSSPPLLPPTETPLLGAFPRDHSSLALVQN 183

  Fly   860 QQPQAPPQIF-NPQPVKPEPLAQPPRPLSNASSSGGPPPAGGASSSGGSGLSGRSKYVLDPSVAA 923
            ....||..|. .|:..||.|:.|||                                     |:.
Mouse   184 GDISAPSAILRTPESTKPGPVCQPP-------------------------------------VSQ 211

  Fly   924 PTSSYGMPYNPVPAPVPSAVPFGGGGVPGPAPQPASVPTYNSNAFNTNP---IAAAQPYNPSPLM 985
            ..|.:.:|..|     |.::....|...|||  ||..|.:.:.||..|.   :...:..|||
Mouse   212 NRSLFSVPSKP-----PVSLEPQNGTYAGPA--PAFQPFFFTGAFPFNMQELVLKVRIQNPS--- 266

  Fly   986 PAQQNQFVP---------------------GVNP 998
             .::|.|:.                     ||||
Mouse   267 -LRENDFIEIELDRQELTYQELLRVSCCELGVNP 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec31	NP_001286215.1	WD40 repeat	11..61	CDD:293791
		WD40	<35..334	CDD:225201
		WD40 repeat	68..114	CDD:293791
		WD40	<80..329	CDD:295369
		WD40 repeat	119..156	CDD:293791
		WD40 repeat	166..202	CDD:293791
		WD40 repeat	209..250	CDD:293791
		WD40 repeat	256..296	CDD:293791
		WD40 repeat	303..328	CDD:293791
		ACE1-Sec16-like	<570..>690	CDD:301350
		RCR	<811..>873	CDD:304939	19/75 (25%)
Ankrd40	NP_082075.2	ANK 1	9..38		9/35 (26%)
		ANK	<14..93	CDD:238125	13/83 (16%)
		Ank_4	14..64	CDD:290365	7/54 (13%)
		ANK repeat	14..40	CDD:293786	6/30 (20%)
		ANK repeat	43..74	CDD:293786	3/30 (10%)
		ANK 2	43..72		3/28 (11%)
		Ank_2	48..>93	CDD:289560	7/44 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	135..167		11/34 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900