DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec31 and Sec31a

DIOPT Version :9

Sequence 1:	NP_001286215.1	Gene:	Sec31 / 35877	FlyBaseID:	FBgn0033339	Length:	1260	Species:	Drosophila melanogaster
Sequence 2:	XP_006535255.1	Gene:	Sec31a / 69162	MGIID:	1916412	Length:	1261	Species:	Mus musculus

Alignment Length:	1350	Identity:	457/1350 - (33%)
Similarity:	692/1350 - (51%)	Gaps:	186/1350 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKIKELQKTVNIAWSPAQQQQILLAAGTAAQQFDS--NANSTLELYSPNFSDATYDLELRASVSS 63
            ||:||:.:|...||||||...|.||.||:|||.|:  :.|::||::..:.||.:.|::..|:.||
Mouse     1 MKLKEIDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLSDPSLDMKSCATFSS 65

  Fly    64 QYKFQKLIWSPVGPHP-------SGLIVGGCEAGQINIYSADKLLAGKEEPLLKRQDKHTGAVSG 121
            .:::.||||   |||.       ||:::.|.|.|.|.:|...|::||.:|.::.::|||||.|..
Mouse    66 SHRYHKLIW---GPHKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGDKEVVIAQKDKHTGPVRA 127

  Fly   122 LDFNPFQNNLLASCASESEILIWDLNNPETSMSPGTKTQPLEDVKNVAWNRQVQHILASVF-STR 185
            ||.|.||.||:||.|:||||.||||||..|.|:||.||||.||:..:||||||||||||.. |.|
Mouse   128 LDVNIFQTNLVASGANESEIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGR 192

  Fly   186 CVIWDLRKSQQIIKLSDSQSRVRWHAIEWHPEAATQVWLASEDDQAPVVQLWDLRYATAPAKTYQ 250
            ..:|||||::.|||:||..:|:....:.|||:.|||:.||||||:.||:|:||||:|::|.:..:
Mouse   193 ATVWDLRKNEPIIKVSDHSNRMHCSGLAWHPDVATQMVLASEDDRLPVIQMWDLRFASSPLRVLE 257

  Fly   251 IHERGVLGMSWCLQDNDLMVSCGKDNRIYCWNPNTKIPEGEILSEVATTASWYSDVQFCPRNPAL 315
            .|.||:|.::|.:.|.:|::|||||.:|.|.||||    ||:|.|:.|...|..|:|:||||||:
Mouse   258 NHARGILAVAWSMADPELLLSCGKDAKILCSNPNT----GEVLYELPTNTQWCFDIQWCPRNPAV 318

  Fly   316 IASASLEGAVSIYSLHGGTHHLV--QTANKIADSFPGMDQFAQ-EP-----IPQQATQ-VVYHDL 371
            :::||.:|.:|:||:.||:...:  :..:|::.||..:|.|.. :|     ||||:.| .:...|
Mouse   319 LSAASFDGRISVYSIMGGSIDGLRQKQVDKLSSSFGNLDPFGTGQPLPPLQIPQQSAQHSIVLPL 383

  Fly   372 AHAPKWMKRPCGVAFGFGGKLVSFNGTS------------KTVKVQQLTTESALVDRANALERSL 424
            ...|||::||.|.:|.||||||:|...:            :.|.:.|:.||...::|:..|:.::
Mouse   384 KKPPKWIRRPVGASFSFGGKLVTFESVAVPLQQGAEQQRRQPVFISQVVTEKDFLNRSAQLQHAV 448

  Fly   425 VDANYSDYCRQRADETPDQHGRYIWYFIKANFELNPKEEMLNLLGYNKDDIDSKFNKFIKETDGN 489
            ....:..||:::.:.:..:..:.:|.|:|.|||.:.:.:.|.||||.|:|:..|....:.:.||
Mouse   449 QSQGFIGYCQKKIEASQTEFEKNVWSFLKVNFEEDSRGKYLELLGYRKEDLGQKIALALNKVDG- 512

  Fly   490 SHSDVDTLTTRISTLTHSDSSEVECDQSTNYSTDNSQTQDNKFDGNAIDSQNHN-DFATPPRPQF 553
                             .|.:..:.||......:.|...:.:..|..|..:... ||.......|
Mouse   513 -----------------PDVALKDSDQVAQSDGEESPAAEEQLLGERIKEEKQECDFLPSAGGTF 560

  Fly   554 KVPSGDHSDSLIAEAILTGNVDAAVELCLEAQRIPEALIIASTAGIETLNRTQTRYLLQQKNELS 618
            .:......|.||..|:||||.::||:|||...|:.:|:|:|...|.|.|.:||.:|..:.:::::
Mouse   561 NISVSGDIDGLITRALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLAQTQKKYFAKSQSKIT 625

  Fly   619 HVISALVSRDWLDFVNRCTVDSWKEALVAALKHSE-RKVVDICERLGDRLLSECASSAEFTRNAM 682
            .:|:|:|.::|.:.|..|.:.:|:|||.|.|.::: .:...:|:.||.||  |....:.....|.
Mouse   626 RLITAVVMKNWREIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRL--EREGDSLLRTQAC 688

  Fly   683 LCYICAGSIDKLVTAWYQLKRLEQQNPGYKPNTTELQDLAEMVMLMCKSLE-QQGISVDLAGR-F 745
            |||||||::::||..|      .:...|..|  ..||||.|.|:::.|::: .|.:..:..|. .
Mouse   689 LCYICAGNVERLVACW------TKAQDGSSP--LSLQDLIEKVVILRKAVQLTQALDTNTVGALL 745

  Fly   746 AGFLTEYGGLLASQGALTAALQYITTLGGGAAASESDVLQSLRDRINNAVNLDYTQPQAAVAAAP 810
            |..:::|..|||:||::.|||.::..     ..::.:::| ||||:..|..
Mouse   746 AEKMSQYASLLAAQGSIAAALAFLPD-----NTNQPNIVQ-LRDRLCKAQG-------------- 790

  Fly   811 HGYQPTRGRGSFSQPQPSAPMPYGQPPNQYAQPSWPAQVPPLQTS--YPGAQQPQAPPQIFNPQP 873
               :|..|:.|...|....|:..|:|    ...:..:|:|.:||.  ||   ..:..|.:.....
Mouse   791 ---KPVSGQESSQSPYERQPLSKGRP----GPVAGHSQMPRVQTQQYYP---HVRIAPTVTTWSN 845

  Fly   874 VKPEPLAQPPRPLSNASSSGGPPPAGGASSSGGSGLSGRSKYVLDPSVAAPTSSYGMPYN--PVP 936
            ..|..|...|...|.:.:.|..||..|....|        ..:.:|:...||:...||..  |.|
Mouse   846 KTPTALPSHPPAASPSDTQGENPPPPGFIMQG--------NVIPNPAAPLPTAPGHMPSQLPPYP 902

  Fly   937 APVP----SAVPFGGGGVPGPAP-QPASVPTYNSNAF-NTNPIAAAQPYNPSPLMPAQQNQFVPG 995
            .|.|    ....||.||.....| ||.:.|.  |||: ||..|:....|:..|.|...|....|.
Mouse   903 QPQPYQPAQQYSFGTGGAAAYRPQQPVAPPA--SNAYPNTPYISPVASYSGQPQMYTAQQASSPT 965

  Fly   996 VNPIETMPPPA---------------------------VPPVIQNV---QRNPT----------- 1019
            .:...:.|||:                           .||....:   ||...
Mouse   966 SSSAASFPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTPPAASELPASQRTENQSFQDQASILE 1030

  Fly  1020 -PPPGWNDPPALKSSRAPKPKPVVEPSAAIFHPLFPV-DPNQNQNGYVDPSQYQHAAPLGGVPNT 1082
             |..||||||||  :|.||.|.:.|.    |.|..|: .|..|.:|  || |.|........|..
Mouse  1031 GPQNGWNDPPAL--NRVPKKKKMPEN----FMPPVPITSPIMNPSG--DP-QSQGLQQQPSTPGP 1086

  Fly  1083 YYNPAAFNNNPQQQQQHQQSYLQPQQP------APGIQQPNWQGQQ-QTIGYTEQPAPIQQQRQP 1140
            ..:.|:|   |||.....|.:...|||      .|...:||.:|.. ..||.|.|    ..|..|
Mouse  1087 LSSHASF---PQQHLAGGQPFHGVQQPLAQTGMPPSFSKPNTEGAPGAPIGNTIQ----HVQALP 1144

  Fly  1141 APPKEKPPLPEEYIYLQTVLEELKNRCLGATNDPRTKRKFVDVVKRLENLYDCLRDGKLTPTTVQ 1205
            .....|.|:|||::.|:|..|:|..|||.:..||:||||..|..||||.|||.||:..|:||.:.
Mouse  1145 TEKITKKPIPEEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTIIN 1209

  Fly  1206 YLNQIVQYIQISDYANAMEIHTQIAFGTDFAQCAGFMQGLKVLLQSASEL 1255
            .|:.|.:.|:..:|:..:.:||.|...::|::.:.||..|||:|..||:|
Mouse  1210 GLHSIARSIETRNYSEGLSVHTHIVSTSNFSETSAFMPVLKVVLSQASKL 1259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec31	NP_001286215.1	WD40 repeat	11..61	CDD:293791	22/51 (43%)
		WD40	<35..334	CDD:225201	148/308 (48%)
		WD40 repeat	68..114	CDD:293791	18/52 (35%)
		WD40	<80..329	CDD:295369	129/249 (52%)
		WD40 repeat	119..156	CDD:293791	23/36 (64%)
		WD40 repeat	166..202	CDD:293791	22/36 (61%)
		WD40 repeat	209..250	CDD:293791	21/40 (53%)
		WD40 repeat	256..296	CDD:293791	18/39 (46%)
		WD40 repeat	303..328	CDD:293791	12/24 (50%)
		ACE1-Sec16-like	<570..>690	CDD:301350	44/120 (37%)
		RCR	<811..>873	CDD:304939	14/63 (22%)
Sec31a	XP_006535255.1	WD40 repeat	13..65	CDD:293791	22/51 (43%)
		WD40 repeat	70..119	CDD:293791	18/51 (35%)
		WD40	84..340	CDD:392136	133/259 (51%)
		WD40 repeat	125..162	CDD:293791	23/36 (64%)
		WD40 repeat	172..208	CDD:293791	22/35 (63%)
		WD40 repeat	214..257	CDD:293791	21/42 (50%)
		WD40 repeat	263..302	CDD:293791	19/42 (45%)
		WD40 repeat	306..331	CDD:293791	12/24 (50%)
		ACE1-Sec16-like	<572..766	CDD:387390	69/203 (34%)
		PHA03247	<750..1132	CDD:223021	111/433 (26%)
		PRK10263	<1060..>1226	CDD:236669	63/175 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849068
Domainoid	1	1.000	428	1.000	Domainoid score	I599
eggNOG	1	0.900	-	-		E1_KOG0307
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H42056
Inparanoid	1	1.050	689	1.000	Inparanoid score	I692
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54150
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002042
OrthoInspector	1	1.000	-	-		otm43306
orthoMCL	1	0.900	-	-		OOG6_101250
Panther	1	1.100	-	-	O	PTHR13923
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2285
SonicParanoid	1	1.000	-	-		X1512
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790