DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sec31 and Ankrd40

DIOPT Version :9

Sequence 1:	NP_001286215.1	Gene:	Sec31 / 35877	FlyBaseID:	FBgn0033339	Length:	1260	Species:	Drosophila melanogaster
Sequence 2:	NP_001128171.1	Gene:	Ankrd40 / 690586	RGDID:	1594678	Length:	363	Species:	Rattus norvegicus

Alignment Length:	355	Identity:	71/355 - (20%)
Similarity:	113/355 - (31%)	Gaps:	117/355 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   701 LKRLEQQNPGYKPNTTELQDLAEMVMLMCKSLEQQGISVDLA-----------------GRFAGF 748
            |::.|||.  .......|.|:.|:     :.|.:.|:.|:..                 |:...:
  Rat     5 LEQKEQQE--RLREAAALGDIREV-----QKLVESGVDVNSQNEVNGWTCLHWACKRNHGQVVSY 62

  Fly   749 LTEYGG---LLASQGALTAAL---QYITTLGGGAAASESDVLQSLRDRINNAVNLDYTQPQAAVA 807
            |.:.|.   :|.::|.:...|   :.|..:.|...|.:.:.:..|:    ....|.:.....|..
  Rat    63 LLQSGADREILTTKGEMPVQLTSRREIRKIMGVEEADDDEEIPQLK----KESELPFVPNYLANP 123

  Fly   808 AAPHGYQPTRGRGSFSQPQPSAPMPYGQPPNQYAQPSWPAQVPPLQTSYPGAQQP---------Q 863
            |.|..|.|.....:..|....:|.|. .||.:.:.|..|...|||..::|.....         .
  Rat   124 AFPFIYTPAAEDATQLQNGGPSPPPV-SPPAEGSPPLLPPTEPPLLGAFPRDHTSLALVQNGDIS 187

  Fly   864 APPQIF-NPQPVKPEPLAQPPRPLSNASSSGGPPPAGGASSSGGSGLSGRSKYVLDPSVAAPTSS 927
            ||..|. .|:..||.|:.|||                                     |:...|.
  Rat   188 APSAILRTPESTKPGPVCQPP-------------------------------------VSQNRSL 215

  Fly   928 YGMPYNPVPAPVPSAVPFGGGGVPGPAPQPASVPTYNSNAFNTNP---IAAAQPYNPSPLMPAQQ 989
            :.:|..|     |.::....|...|||  ||..|.:.:.||..|.   :...:..|||    .::
  Rat   216 FSVPSKP-----PVSLEPQNGTYAGPA--PAFQPFFFTGAFPFNMQELVLKVRIQNPS----LRE 269

  Fly   990 NQFVP---------------------GVNP 998
            |.|:.                     ||||
  Rat   270 NDFIEIELDRQELTYQELLRVSCCELGVNP 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec31	NP_001286215.1	WD40 repeat	11..61	CDD:293791
		WD40	<35..334	CDD:225201
		WD40 repeat	68..114	CDD:293791
		WD40	<80..329	CDD:295369
		WD40 repeat	119..156	CDD:293791
		WD40 repeat	166..202	CDD:293791
		WD40 repeat	209..250	CDD:293791
		WD40 repeat	256..296	CDD:293791
		WD40 repeat	303..328	CDD:293791
		ACE1-Sec16-like	<570..>690	CDD:301350
		RCR	<811..>873	CDD:304939	17/71 (24%)
Ankrd40	NP_001128171.1	ANK	<14..93	CDD:238125	13/83 (16%)
		Ank_4	14..64	CDD:290365	7/54 (13%)
		ANK repeat	14..40	CDD:293786	6/30 (20%)
		ANK repeat	43..74	CDD:293786	3/30 (10%)
		Ank_2	48..>93	CDD:289560	7/44 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900