DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec31 and sec31a

DIOPT Version :9

Sequence 1:	NP_001286215.1	Gene:	Sec31 / 35877	FlyBaseID:	FBgn0033339	Length:	1260	Species:	Drosophila melanogaster
Sequence 2:	XP_012816255.1	Gene:	sec31a / 496576	XenbaseID:	XB-GENE-5955093	Length:	1261	Species:	Xenopus tropicalis

Alignment Length:	1358	Identity:	473/1358 - (34%)
Similarity:	707/1358 - (52%)	Gaps:	202/1358 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKIKELQKTVNIAWSPAQQQQILLAAGTAAQQFDS--NANSTLELYSPNFSDATYDLELRASVSS 63
            ||:||:.:|...|||.:|...|.||.||:|||.|:  :.|::||::..:.:|.:.|::..|:.||
Frog     1 MKLKEIDRTAMQAWSHSQYHPIYLATGTSAQQLDATFSTNASLEIFELDLADPSMDMKSCATFSS 65

  Fly    64 QYKFQKLIWSPVGPH-------PSGLIVGGCEAGQINIYSADKLLAGKEEPLLKRQDKHTGAVSG 121
            .:::.||||   |||       .||:::.|.|.|.:.:|...|::.|..|.::.:||||||.|..
Frog    66 THRYHKLIW---GPHRTASNGSASGVLIAGGENGNVILYDPAKIIEGDREVVIAQQDKHTGPVRA 127

  Fly   122 LDFNPFQNNLLASCASESEILIWDLNNPETSMSPGTKTQPLEDVKNVAWNRQVQHILASVF-STR 185
            ||.|.||.||:||.|:||||.||||||....|:||.|:|||||:..:||||||||||||.. |.|
Frog   128 LDVNSFQTNLVASGANESEIYIWDLNNFAVPMTPGAKSQPLEDIGCIAWNRQVQHILASASPSGR 192

  Fly   186 CVIWDLRKSQQIIKLSDSQSRVRWHAIEWHPEAATQVWLASEDDQAPVVQLWDLRYATAPAKTYQ 250
            ..:|||||::.|:|:||..:|:....:.|||:.|||:.|:||||:.||:|:||||:|::|.:..:
Frog   193 ATVWDLRKNEPILKVSDHSNRMHCSGMAWHPDVATQMVLSSEDDRLPVIQMWDLRFASSPLRVIE 257

  Fly   251 IHERGVLGMSWCLQDNDLMVSCGKDNRIYCWNPNTKIPEGEILSEVATTASWYSDVQFCPRNPAL 315
            .|.||:|.::|.|.|.:|::|.|||:||.|.||||    ||:|.|:.|...|..|:|:||||||:
Frog   258 SHTRGILAIAWSLADPELLLSSGKDSRILCSNPNT----GEVLYELPTNMQWCFDMQWCPRNPAV 318

  Fly   316 IASASLEGAVSIYSLHGGTHHLV--QTANKIADSFPGMDQFAQ-EP-----IPQQATQ---VVYH 369
            :::||.:|.:||||:.||.:..:  :.|:|::.||..:|.|.. .|     :|||.||   :|
Frog   319 LSAASFDGRISIYSIMGGNNDSLSQKQADKLSSSFGNLDPFGTGHPLPPLQLPQQPTQQNTIV-- 381

  Fly   370 DLAHAPKWMKRPCGVAFGFGGKLVSFNGTSKT-----------------VKVQQLTTESALVDRA 417
            .|...||||:.|.|.:|.||||||:|. |..|                 |.|.|:.||...:.|:
Frog   382 PLKKPPKWMRCPVGASFSFGGKLVTFE-TVNTQTAQQQQHPEAEPHHFHVYVSQVVTEKEFLTRS 445

  Fly   418 NALERSLVDANYSDYCRQRADETPDQHGRYIWYFIKANFELNPKEEMLNLLGYNKDDIDSKF--- 479
            |.|:..:....:.|||:::.::......:.:|.|:|.|||.:.:.:.|.|||:.|||:.||.
Frog   446 NQLQDVVSTGTFIDYCQKKVEDAKTDFEKDVWSFLKVNFEEDTRGKYLELLGFRKDDLSSKIASV 510

  Fly   480 --NKFIKETDGNSHSDVDTLTTRISTLTHSDSSEVECDQSTNYSTDNSQTQDNKFDGNAIDSQNH 542
              |::  .|||:..::.|           ||.:....::...:|.||...:.:|.|.......|
Frog   511 MGNEY--ATDGDHEAEKD-----------SDQAIASDEEERQHSEDNFLAEVSKDDKRQSSGSN- 561

  Fly   543 NDFATPPRPQFKVPSGDHSDSLIAEAILTGNVDAAVELCLEAQRIPEALIIASTAGIETLNRTQT 607
                :|......:.||| .|.||.:|:||||.::||.|||...|:.:|:|:|...|.|.|.:||.
Frog   562 ----SPGESLNILVSGD-VDGLITQALLTGNFESAVNLCLHDNRMADAVILAIAGGPELLAKTQR 621

  Fly   608 RYLLQQKNELSHVISALVSRDWLDFVNRCTVDSWKEALVAALKHSE-RKVVDICERLGDRLLSEC 671
            :|..:.:::::.:|:|:|:::|.:.|..|.:.:|:|||.|.|.::: .:...:|:.||.||.:|
Frog   622 KYFAKSQSKITRLITAVVTKNWNEIVQSCDLKNWREALAAVLTYTKPDEFSSLCDLLGSRLENE- 685

  Fly   672 ASSAEFTRNAMLCYICAGSIDKLVTAWYQLKRLEQQNPGYKPN-TTELQDLAEMVMLMCKSLEQQ 735
             ........|.|||||||:::|||:.|         ...:..| :..||||.|.|:::.|::|..
Frog   686 -GDIALQTQACLCYICAGNVEKLVSCW---------TKAHDSNCSLALQDLIEKVVILRKAVETN 740

  Fly   736 GISVDLAGRFAGFLTEYGGLLASQGALTAALQYITTLGGGAAASESDVLQSLRDRINNA---VNL 797
            .:...|:.:    :::|..:||:||:|.||:.::.|     .|.:.||:| ||:|:..|   ||:
Frog   741 DMGTILSQK----MSQYANVLAAQGSLAAAMAFLPT-----DAHQGDVVQ-LRERLCRAQGQVNI 795

  Fly   798 DYTQPQAAV----AAAPHGYQPTRGRGSFSQPQPSAPMPYGQPPNQYAQPSWPAQVPPLQTSYPG 858
              ..|.|.|    :...||.:|.         ||...|.|      |.|    |::.|..||:..
Frog   796 --IAPAAGVTRSGSTQQHGAKPV---------QPGTDMQY------YPQ----ARIAPTVTSWSN 839

  Fly   859 AQQPQAPPQIFNPQPVKPEPLAQPPRPL-----SNASSSGGPPPAGGASSSG-----GSGLSGRS 913
             :.|.|.|. |.|.....:.......||     .:..:||.......|.||.     .|.::.|.
Frog   840 -KNPTALPS-FAPAASSFDTQRNSALPLGFNIPGSTYTSGSLASVASADSSAPSYNINSQITPRL 902

  Fly   914 KYVLDPSVAAPTSSYGM----PYNP-VPAPVPSAVPFGGGGVPGPAPQPASVPTYNSNAFNTNPI 973
            .| ..|.:.:...||||    .|.| .|:.||||.|:....... |.|..:.|.|...|. .:|.
Frog   903 PY-SQPYLQSQQYSYGMGGPAVYQPQPPSTVPSATPYHNSSYTS-ASQTTTQPLYPGPAL-LSPA 964

  Fly   974 AAAQPYNPSPLMPAQQNQFV---PGVNPIET----MPPP----AVP-----PVIQNVQRNPT--- 1019
            ::|.    |.|.|:....|.   ||. |..|    :|||    .:|     |..|..:....
Frog   965 SSAS----SSLPPSSGASFQHGGPGA-PANTAHCALPPPGSTGTLPATSELPASQRTEYQSAQDT 1024

  Fly  1020 -----PPPGWNDPPALKSSRAPKPKPVVE---PSAAIFHPLFPVDPNQNQNGYVDPSQYQHAAPL 1076
                 |..||||||||  ||..| |.|:|   |...|..|:        .|...|||..|...|.
Frog  1025 TYIQGPLNGWNDPPAL--SRISK-KKVLENYVPPPPITAPI--------MNPVTDPSSQQQQIPA 1078

  Fly  1077 GG--VPNTYYNPAAFNNNPQQQQQHQQSY--LQPQQPAPGI----QQPNWQGQQ-QTIGYTEQPA 1132
            .|  :|:..:.|:..   ...|...|.|:  .||....||:    .:|:.:|.. ..||.|.|..
Frog  1079 SGTQMPSIPFQPSTM---LVAQPGTQTSFPISQPCNSQPGLPLESSKPSMEGAPGAPIGNTIQAI 1140

  Fly  1133 PIQQQRQPAPPKEKPPLPEEYIYLQTVLEELKNRCLGATNDPRTKRKFVDVVKRLENLYDCLRDG 1197
                ...||....|.|:|.|::.|:|..|.|..|||.:.|||:||||..|..||||.|||.||:.
Frog  1141 ----HTLPAEKIVKNPIPGEHLILKTTFEALIQRCLCSANDPQTKRKLDDANKRLEYLYDKLREQ 1201

  Fly  1198 KLTPTTVQYLNQIVQYIQISDYANAMEIHTQIAFGTDFAQCAGFMQGLKVLLQSASEL 1255
            .|:|..:..|:.|.:.|:..:|...:.|||.|...::|::.:.||..|||:|..|::|
Frog  1202 TLSPAIIAGLHNIARSIESRNYTEGLNIHTHIVSTSNFSETSAFMPVLKVVLTQANKL 1259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec31	NP_001286215.1	WD40 repeat	11..61	CDD:293791	19/51 (37%)
		WD40	<35..334	CDD:225201	145/308 (47%)
		WD40 repeat	68..114	CDD:293791	17/52 (33%)
		WD40	<80..329	CDD:295369	127/249 (51%)
		WD40 repeat	119..156	CDD:293791	22/36 (61%)
		WD40 repeat	166..202	CDD:293791	21/36 (58%)
		WD40 repeat	209..250	CDD:293791	20/40 (50%)
		WD40 repeat	256..296	CDD:293791	19/39 (49%)
		WD40 repeat	303..328	CDD:293791	12/24 (50%)
		ACE1-Sec16-like	<570..>690	CDD:301350	44/120 (37%)
		RCR	<811..>873	CDD:304939	18/61 (30%)
sec31a	XP_012816255.1	WD40 repeat	13..65	CDD:293791	19/51 (37%)
		WD40 repeat	70..119	CDD:293791	16/51 (31%)
		WD40	121..336	CDD:392136	117/218 (54%)
		WD40 repeat	125..162	CDD:293791	22/36 (61%)
		WD40 repeat	172..208	CDD:293791	21/35 (60%)
		WD40 repeat	214..257	CDD:293791	20/42 (48%)
		WD40 repeat	263..302	CDD:293791	20/42 (48%)
		WD40 repeat	306..331	CDD:293791	12/24 (50%)
		ACE1-Sec16-like	<579..>702	CDD:387390	45/124 (36%)
		PHA03247	<751..1132	CDD:223021	120/431 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	420	1.000	Domainoid score	I637
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H42056
Inparanoid	1	1.050	679	1.000	Inparanoid score	I714
OMA	1	1.010	-	-		QHG54150
OrthoDB	1	1.010	-	-		D100998at2759
OrthoFinder	1	1.000	-	-		FOG0002042
OrthoInspector	1	1.000	-	-		otm48455
Panther	1	1.100	-	-	O	PTHR13923
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2285
SonicParanoid	1	1.000	-	-		X1512
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110