DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec31 and sec31a

DIOPT Version :9

Sequence 1:	NP_001286215.1	Gene:	Sec31 / 35877	FlyBaseID:	FBgn0033339	Length:	1260	Species:	Drosophila melanogaster
Sequence 2:	XP_009303363.1	Gene:	sec31a / 266638	ZFINID:	ZDB-GENE-020919-2	Length:	1558	Species:	Danio rerio

Alignment Length:	1646	Identity:	493/1646 - (29%)
Similarity:	725/1646 - (44%)	Gaps:	481/1646 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKIKELQKTVNIAWSPAQQQQILLAAGTAAQQFDS--NANSTLELYSPNFSDATYDLELRASVSS 63
            ||:||:.:|...|||||||..|.|||||:|||.|:  :.|::||::..:.:|:...::...|.||
Zfish     1 MKLKEINRTAIQAWSPAQQHPIYLAAGTSAQQLDATFSTNASLEIFELDLADSALAMKSCGSFSS 65

  Fly    64 QYKFQKLIWSPVGPH-------PSGLIVGGCEAGQINIYSADKLLAGKEEPLLKRQDKHTGAVSG 121
            .:::.||:|   |||       |||:::.|.|.|.|.:|.|.|::||..|.::.:.:||||||..
Zfish    66 PHRYHKLVW---GPHGIENQGLPSGVLIAGGENGNIILYDASKIIAGDSEVIILQSEKHTGAVRA 127

  Fly   122 LDFNPFQNNLLASCASESEILIWDLNNPETSMSPGTKTQPLEDVKNVAWNRQVQHILASVF-STR 185
            ||.|.||:||:||..:||||.||||||..:.|:||.||||.||:..||||:||||||||.. |.:
Zfish   128 LDVNSFQSNLVASGGNESEIYIWDLNNFSSPMTPGPKTQPQEDISCVAWNKQVQHILASASPSGK 192

  Fly   186 CVIWDLRKSQQIIKLSDSQSRVRWHAIEWHPEAATQVWLASEDDQAPVVQLWDLRYATAPAKTYQ 250
            ..:|||||:..|||:||..:|:....:.|:||.|||:.||||||:.||:|:||||:||:|.|..:
Zfish   193 ASVWDLRKNDLIIKVSDHSNRMHCSGLAWNPEVATQLVLASEDDRMPVIQMWDLRFATSPLKVLE 257

  Fly   251 IHERGVLGMSWCLQDNDLMVSCGKDNRIYCWNPNTKIPEGEILSEVATTASWYSDVQFCPRNPAL 315
            .|.||:|.::|.:.|.:|::||||||||.||||||    .|:|.|:.|:..|..|:|:||||||:
Zfish   258 NHTRGILAIAWSVADPELLLSCGKDNRILCWNPNT----AEVLYELPTSTQWCFDIQWCPRNPAV 318

  Fly   316 IASASLEGAVSIYSLHGGTHHLVQT--ANKIADSFPGMDQFAQE------PIPQQAT-QVVYHDL 371
            :::|:.:|.:||||:.||::.....  |::::.||..||.|...      .:|||.: |.....|
Zfish   319 LSAAAFDGHISIYSIMGGSNDNANNLQADQLSSSFGNMDPFGTGKTLPPLQLPQQTSPQSTITPL 383

  Fly   372 AHAPKWMKRPCGVAFGFGGKLVSFNGTSKT-----------VKVQQLTTESALVDRANALERSLV 425
            ...|||::||.|.:|.||||||:.:....|           |.:.|:.||:..:.|:|.|:.:|.
Zfish   384 KKPPKWIRRPVGASFAFGGKLVTLDNIKPTAQQPQQTAAHVVHISQVVTETDFIHRSNQLQTTLN 448

  Fly   426 DANYSDYCRQRADETPDQHGRYIWYFIKANFELNPKEEMLNLLGYNKDDIDSKFNKFI------K 484
            ..|:.:||:.:.:...::..|.:|.|:|.|||.:.:.:.|.||||.|:::..|....:      |
Zfish   449 AGNFLEYCQNKIETVQNEFERTVWSFLKVNFEEDARLKYLELLGYEKEELALKIASALEGNCKPK 513

  Fly   485 ETD-------------------------------------GNSHSDVDTLTTR------------ 500
            |.|                                     ..|..|.|.|..:
Zfish   514 EADMLSIIPASIPLQHTTPAPDPLSDPLPDISNNPEPVLETQSEPDPDALLVQPRIEPKYASPPN 578

  Fly   501 ---------------------------------------IST---------LTHS---------- 507
                                                   ::|         ||||
Zfish   579 LELHLQFVNDPIFESTTVPSANTLQPHSQTLVDFTPPVDLTTLFDLTPPVDLTHSFDQTPPVGIA 643

  Fly   508 ----------DSSEVE----------------CDQSTNYSTDNS--------------------- 525
                      .|.:|.                |.|.:|.:.:::
Zfish   644 APVDIVTQVGPSGQVSSPEEQLDSLPLLTPSTCPQESNLALESTDLLLPTESTATMVPHQSSCGA 708

  Fly   526 -------------------QTQ------------------------------------------- 528
                               ||:
Zfish   709 TTVEFQQSVPITEQGFGVVQTEYLEPAQASTIGLHLASGCDPLDAPGLSPDILPQEAVSMQVLNV 773

  Fly   529 ------------------------------------DNKFDGNA-----IDSQNHNDFA------ 546
                                                |:..:|.|     :|.......|
Zfish   774 DPQLPTQESDLMISVADLLNVSDCKLELQVEDVLGGDDPNNGRAKEETKLDEDKEEVLAEEEADS 838

  Fly   547 ---------------------TPPRP-----QFKVPSGDHSDSLIAEAILTGNVDAAVELCLEAQ 585
                                 .||.|     ..||  ....|.||.:|:|||:.:|||.|||...
Zfish   839 DLDDIPVNEEEPVVEETSNTEVPPAPASDAINLKV--SQDIDGLITQALLTGDYEAAVNLCLHDN 901

  Fly   586 RIPEALIIASTAGIETLNRTQTRYLLQQKNELSHVISALVSRDWLDFVNRCTVDSWKEALVAALK 650
            |:.:.:|:|...|.|.|.:||.:|..:.::::|.:|||:|.:||||.:..|.:.:|||||.|.:.
Zfish   902 RMADGIILAIAGGPELLAKTQRKYFSKTESKISKLISAVVMKDWLDILETCDLQNWKEALAAVMT 966

  Fly   651 HSE-RKVVDICERLGDRLLSECASSAEFTRNAMLCYICAGSIDKLVTAWYQLKRLEQQNPGYKPN 714
            ::: .:...:|..||.||  |.:...|....|.|||||||::::||:.|  .|..:..:|
Zfish   967 YAKPEEFSALCGLLGSRL--ESSEDVELQAQACLCYICAGTVEQLVSFW--TKTQDSCSP----- 1022

  Fly   715 TTELQDLAEMVMLMCKSLE--QQGISVDLAGRFAGFLTEYGGLLASQGALTAALQYITTLGGGAA 777
             ..||:|.|.|:::.:::|  |..:..|:....|..:.:|..||||||:|..|:.|:.|
Zfish  1023 -LSLQELVEKVVVLQRAVEKAQGAVPADMGALLAEKMNQYASLLASQGSLQTAISYLPT------ 1080

  Fly   778 ASESDVLQSLRDRINNAVNLDY--TQPQAAVAAAPHGYQPTRGRG----SFSQPQPSA-PMPYGQ 835
            .:|...:|.||:|::.|:....  .||.|||......:| ||...    ::|||||.| |.....
Zfish  1081 NTEQVSVQQLRERLSRALGQHQHPQQPAAAVTGIQKMHQ-TRPAAVPMQTYSQPQPPAQPAAPAV 1144

  Fly   836 PPNQYAQ-------PSWPAQVPPLQTSYPGAQQPQAPPQIFNPQPVKPEPLAQPPRPLSNASSSG 893
            ||..|.|       .||..|.|....|.|....|.:.||                        ..
Zfish  1145 PPQYYQQGRSATTVTSWSNQTPTALPSVPRQLVPSSDPQ------------------------GD 1185

  Fly   894 GPPPAGGASSSGGSGLSGRSKYVLD------PSVAAPTSSYGMP--YNPVP------APVPSAVP 944
            ..|||.|..|...:.:...:.::..      |.|...|.|.|.|  |.|:|      :|:|
Zfish  1186 STPPAFGLQSPAMASVPASTPFMYSQQYQNYPPVQQFTPSAGTPGIYQPLPYASSAGSPLP---- 1246

  Fly   945 FGGGGVPGPAPQPASV--PTYNSNAFNTNPIAAAQPYNPSPLMPA----QQNQFVPGVNPIETMP 1003
                  |.|:...|:|  |.:..:| ::...|..|.:.|.|.:.:    |...  || :|...:|
Zfish  1247 ------PPPSSSSAAVYPPQFMLSA-SSQASAPPQSFCPPPAVSSGGCFQHGG--PG-SPTSYLP 1301

  Fly  1004 PPAV--------PPVIQNVQRN-----------PTPPPGWNDPPALKSSRAPKPKPVVE---PSA 1046
            ||..        |.:|...||.           ..|..||||||||  |||.|.|.|.:   |.|
Zfish  1302 PPGARAPGTQHEPALIPASQRTDGFYQETAWGLEGPQNGWNDPPAL--SRAAKKKKVPQHFTPPA 1364

  Fly  1047 AIFHPLF-PV-DPNQNQNGYVDPSQYQHAAPLGGVPNTYYNPAAFNNNPQQQQQHQQSYLQPQQP 1109
            .|..|:. |: ||..       |:..|...|...||:....||.|  .|.|||.     |.|:.|
Zfish  1365 PITAPIMAPLGDPQA-------PAGMQTLQPQQQVPDQSAGPATF--TPIQQQP-----LGPRNP 1415

  Fly  1110 APGIQQPNWQGQQQTIGYTEQPAPIQQQRQP--APPKE---KPPLPEEYIYLQTVLEELKNRCLG 1169
            :  :.|.|.:|        ...|||....:|  |.|.|   |.|:|||::.|:|..|.|..:||.
Zfish  1416 S--MPQGNMEG--------APGAPIGDVIKPLQAIPTEKITKKPIPEEHMVLKTTFEGLIQKCLT 1470

  Fly  1170 ATNDPRTKRKFVDVVKRLENLYDCLRDGKLTPTTVQYLNQIVQYIQISDYANAMEIHTQIAFGTD 1234
            |.:||:||||..|..||||.|||.||:..|:|..:..|:.:...|:...||:.:.|||.|...::
Zfish  1471 AASDPQTKRKLDDAHKRLELLYDKLREQTLSPAIIGGLHNMAHSIECRSYADGLNIHTHIVSNSN 1535

  Fly  1235 FAQCAGFMQGLKVLLQSASEL 1255
            |::.:.||..|||:|..|::|
Zfish  1536 FSETSAFMPVLKVVLTQANKL 1556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec31	NP_001286215.1	WD40 repeat	11..61	CDD:293791	21/51 (41%)
		WD40	<35..334	CDD:225201	148/308 (48%)
		WD40 repeat	68..114	CDD:293791	19/52 (37%)
		WD40	<80..329	CDD:295369	131/249 (53%)
		WD40 repeat	119..156	CDD:293791	21/36 (58%)
		WD40 repeat	166..202	CDD:293791	21/36 (58%)
		WD40 repeat	209..250	CDD:293791	23/40 (58%)
		WD40 repeat	256..296	CDD:293791	20/39 (51%)
		WD40 repeat	303..328	CDD:293791	11/24 (46%)
		ACE1-Sec16-like	<570..>690	CDD:301350	48/120 (40%)
		RCR	<811..>873	CDD:304939	23/73 (32%)
sec31a	XP_009303363.1	WD40 repeat	13..69	CDD:293791	24/55 (44%)
		WD40 repeat	71..118	CDD:293791	19/49 (39%)
		WD40	86..337	CDD:295369	134/254 (53%)
		WD40	<88..407	CDD:225201	157/322 (49%)
		WD40 repeat	125..162	CDD:293791	21/36 (58%)
		WD40 repeat	172..208	CDD:293791	21/35 (60%)
		WD40 repeat	214..257	CDD:293791	23/42 (55%)
		WD40 repeat	263..301	CDD:293791	21/41 (51%)
		WD40 repeat	306..331	CDD:293791	11/24 (46%)
		ACE1-Sec16-like	<881..1078	CDD:301350	74/206 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594621
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0307
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H42056
Inparanoid	1	1.050	708	1.000	Inparanoid score	I638
OMA	1	1.010	-	-		QHG54150
OrthoDB	1	1.010	-	-		D100998at2759
OrthoFinder	1	1.000	-	-		FOG0002042
OrthoInspector	1	1.000	-	-		otm26074
orthoMCL	1	0.900	-	-		OOG6_101250
Panther	1	1.100	-	-	O	PTHR13923
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2285
SonicParanoid	1	1.000	-	-		X1512
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800