DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec31 and SEC31B

DIOPT Version :9

Sequence 1:	NP_001286215.1	Gene:	Sec31 / 35877	FlyBaseID:	FBgn0033339	Length:	1260	Species:	Drosophila melanogaster
Sequence 2:	NP_056305.1	Gene:	SEC31B / 25956	HGNCID:	23197	Length:	1179	Species:	Homo sapiens

Alignment Length:	1323	Identity:	432/1323 - (32%)
Similarity:	664/1323 - (50%)	Gaps:	214/1323 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKIKELQKTVNIAWSPAQQQQILLAAGTAAQQFDS--NANSTLELYSPNFSDATYDLELRASVSS 63
            ||:|||::....|||||.|..:.||.||:|||.||  :.|.|||::..:|.|.:.||:.|..:|:
Human     1 MKLKELERPAVQAWSPASQYPLYLATGTSAQQLDSSFSTNGTLEIFEVDFRDPSLDLKHRGVLSA 65

  Fly    64 QYKFQKLIWSPVGP---HPSGLIVGGCEAGQINIYSADKLLAGKEEPLLKRQDKHTGAVSGLDFN 125
            ..:|.||:|...|.   ..||:||||.:.|.:.:|:...:|:..:||::.::.||||||..||.|
Human    66 LSRFHKLVWGSFGSGLLESSGVIVGGGDNGMLILYNVTHILSSGKEPVIAQKQKHTGAVRALDLN 130

  Fly   126 PFQNNLLASCASESEILIWDLNNPETSMSPGTKT-QPLEDVKNVAWNRQVQHILASVF-STRCVI 188
            |||.|||||.||:|||.||||||....|:.|:|: ||.||:|.::||||.||||:|.. |.:.|:
Human   131 PFQGNLLASGASDSEIFIWDLNNLNVPMTLGSKSQQPPEDIKALSWNRQAQHILSSAHPSGKAVV 195

  Fly   189 WDLRKSQQIIKLSDSQSRVRWHAIEWHPEAATQVWLASEDDQAPVVQLWDLRYATAPAKTYQIHE 253
            |||||::.|||:||..:|:....:.|||:.|||:.|.||||:.||:||||||:|::|.|..:.|.
Human   196 WDLRKNEPIIKVSDHSNRMHCSGLAWHPDIATQLVLCSEDDRLPVIQLWDLRFASSPLKVLESHS 260

  Fly   254 RGVLGMSWCLQDNDLMVSCGKDNRIYCWNPNTKIPEGEILSEVATTASWYSDVQFCPRNPALIAS 318
            ||:|.:||...|.:|:::..||::|.|.|    :...|::.::.|.:||..|||:|||:|::.::
Human   261 RGILSVSWSQADAELLLTSAKDSQILCRN----LGSSEVVYKLPTQSSWCFDVQWCPRDPSVFSA 321

  Fly   319 ASLEGAVSIYSLHGGT---HHLVQTANKIADSFPGMDQFAQEPIPQQATQV-VYHDLAHAPKWMK 379
            ||..|.:|:||:.|.:   .|:.| |:||:.||..........:|:|..|. :...|...|||::
Human   322 ASFNGWISLYSVMGRSWEVQHMRQ-ADKISSSFSKGQPLPPLQVPEQVAQAPLIPPLKKPPKWIR 385

  Fly   380 RPCGVAFGFGGKLVSFNGTS-----------KTVKVQQLTTESALVDRANALERSLVDANYSDYC 433
            ||.||:|.||||||:|...|           :.|.:.|:||||..:.|:..|:.:|...|..:||
Human   386 RPTGVSFAFGGKLVTFGLPSTPAHLVPQPCPRLVFISQVTTESEFLMRSAELQEALGSGNLLNYC 450

  Fly   434 RQRADETPDQHGRYIWYFIKANFELNPKEEMLNLLGYNKDDIDSKFNKFIKETDGNSHS------ 492
            :.::.:...|..:.:|.|:|...|.:.:.:.|.||||:||::..|...::|...|...|
Human   451 QNKSQQALLQSEKMLWQFLKVTLEQDSRMKFLKLLGYSKDELQKKVATWLKSDVGLGESPQPKGN 515

  Fly   493 DVDTLTTRISTLTHSDSSEVECDQSTNYSTDNSQTQDNKFDGNAIDSQNHNDFATPPRPQFKVPS 557
            |:           :||..:..|.|::.::|..:......||  .:..||    .||    :::|.
Human   516 DL-----------NSDRQQAFCSQASKHTTKEASASSAFFD--ELVPQN----MTP----WEIPI 559

  Fly   558 GDHSDSLIAEAILTGNVDAAVELCLEAQRIPEALIIASTAGIETLNRTQTRYLLQQKNELSHVIS 622
            ....|.|:::|:|.|.:..||||||:.:|..:|:|:|...|.:.|.:||.|||.::|.::|.:::
Human   560 TKDIDGLLSQALLLGELGPAVELCLKEERFADAIILAQAGGTDLLKQTQERYLAKKKTKISSLLA 624

  Fly   623 ALVSRDWLDFVNRCTVDSWKEALVAALKHS-ERKVVDICERLGDRLLSECASSAEFTRNAMLCYI 686
            .:|.::|.|.|..|::.:|:|||...|.:| ..|..::|:.||.|:..|  .|...|..|.|||:
Human   625 CVVQKNWKDVVCTCSLKNWREALALLLTYSGTEKFPELCDMLGTRMEQE--GSRALTSEARLCYV 687

  Fly   687 CAGSIDKLVTAWYQLKRLEQQNPGYKPNTTELQDLAEMVMLMCKSLEQ----QGISVDLAGRFAG 747
            |:||:::||..|  .|..:..:|      ..||||.|.||::.:||||    .|:|...|..:.
Human   688 CSGSVERLVECW--AKCHQALSP------MALQDLMEKVMVLNRSLEQLRGPHGVSPGPATTYR- 743

  Fly   748 FLTEYGGLLASQGALTAALQYITTLGGGAAASESDVLQSLRDRINNA--------VNLDYTQPQA 804
             :|:|..|||:||:|..|:.::      ........:|.||||:.:|        .:..:..|:.
Human   744 -VTQYANLLAAQGSLATAMSFL------PRDCAQPPVQQLRDRLFHAQGSAVLGQQSPPFPFPRI 801

  Fly   805 AVAAAPHGYQPTRGR-GSFSQPQPSAPMPYGQP-PNQYAQPSWPAQVPPLQTSYPGAQQPQAPPQ 867
            .|.|..|..:.:..| ||    |||..:|...| |..:...|.||.  ||..|:|   .|...|:
Human   802 VVGATLHSKETSSYRLGS----QPSHQVPTPSPRPRVFTPQSSPAM--PLAPSHP---SPYQGPR 857

  Fly   868 IFN--------PQPVKPEPLAQPPRPLSNASS-SGG-----PPPAGGASSSGGSGLSGRSKYVLD 918
            ..|        ||.::|.||:...||.|:... .||     |.|.|   ..|...|.|....:..
Human   858 TQNISDYRAPGPQAIQPLPLSPGVRPASSQPQLLGGQRVQVPNPVG---FPGTWPLPGSPLPMAC 919

  Fly   919 PSVAAPTSSYGMPYNPVPAPVPSAVPFGGGGVPG--PAPQPASVPTYNSNAFNTNPIAAAQPYNP 981
            |.:..|.|: .:|..|...|:....|.|.|.:..  ||| |||.|.               ||.|
Human   920 PGIMRPGST-SLPETPRLFPLLPLRPLGPGRMVSHTPAP-PASFPV---------------PYLP 967

  Fly   982 SPLMPAQQNQFVPGVNPIETMPPPAVPPVIQNVQRNPTPPPGWNDPPA----LKSSRAPK----P 1038
            ..          ||.      |..:|.|....:..:|.|...|.:.||    |:.::.|:    |
Human   968 GD----------PGA------PCSSVLPTTGILTPHPGPQDSWKEAPAPRGNLQRNKLPETFMPP 1016

  Fly  1039 KPVVEPSAAIFHPLFPVDPNQNQNGYVDP-SQYQHAAPLGGVPNTYYNPAAFNNNPQQQQQHQQS 1102
            .|:..|..::...|..:.|:|      .| |...||.|  |||.
Human  1017 APITAPVMSLTPELQGILPSQ------PPVSSVSHAPP--GVPG--------------------- 1052

  Fly  1103 YLQPQQPAPGIQQPNWQGQQQTIGYTEQPAPIQQQRQPAPPKEKPPLPEEYIYLQTVLEELKNRC 1167
                                        ...:|.|..|....|:..||.|:..|::..|.|..||
Human  1053 ----------------------------ELSLQLQHLPPEKMERKELPPEHQSLKSSFEALLQRC 1089

  Fly  1168 LGATNDPRTKRKFVDVVKRLENLYDCLRDGKLTPTTVQYLNQIVQYIQISDYANAMEIHTQIAFG 1232
            ..:..|.:||||..:..:|||.||:.|.:|.|:|..|..|:::.:.:....:...:.:|.|:|..
Human  1090 SLSATDLKTKRKLEEAAQRLEYLYEKLCEGTLSPHVVAGLHEVARCVDAGSFEQGLAVHAQVAGC 1154

  Fly  1233 TDFAQCAGFMQGLKVLLQSASEL 1255
            :.|::.:.||..||.:|..|.:|
Human  1155 SSFSEVSSFMPILKAVLIIAHKL 1177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec31	NP_001286215.1	WD40 repeat	11..61	CDD:293791	24/51 (47%)
		WD40	<35..334	CDD:225201	138/305 (45%)
		WD40 repeat	68..114	CDD:293791	15/48 (31%)
		WD40	<80..329	CDD:295369	119/250 (48%)
		WD40 repeat	119..156	CDD:293791	24/36 (67%)
		WD40 repeat	166..202	CDD:293791	20/36 (56%)
		WD40 repeat	209..250	CDD:293791	22/40 (55%)
		WD40 repeat	256..296	CDD:293791	11/39 (28%)
		WD40 repeat	303..328	CDD:293791	11/24 (46%)
		ACE1-Sec16-like	<570..>690	CDD:301350	45/120 (38%)
		RCR	<811..>873	CDD:304939	21/71 (30%)
SEC31B	NP_056305.1	WD40	13..332	CDD:295369	149/322 (46%)
		WD 1	17..56		17/38 (45%)
		WD40	36..356	CDD:225201	144/324 (44%)
		WD 2	67..110		14/42 (33%)
		WD40 repeat	70..118	CDD:293791	15/47 (32%)
		WD 3	119..159		28/39 (72%)
		WD40 repeat	124..161	CDD:293791	24/36 (67%)
		WD 4	166..206		22/39 (56%)
		WD40 repeat	172..208	CDD:293791	20/35 (57%)
		WD 5	209..254		23/44 (52%)
		WD40 repeat	214..257	CDD:293791	22/42 (52%)
		WD 6	258..298		14/43 (33%)
		WD40 repeat	263..303	CDD:293791	12/43 (28%)
		WD 7	301..341		17/39 (44%)
		WD40 repeat	306..331	CDD:293791	11/24 (46%)
		WD 8, interaction with SEC13. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221	391..422		10/30 (33%)
		ACE1-Sec16-like	561..>691	CDD:301350	48/131 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	812..856		17/52 (33%)
		MISS	837..1052	CDD:292450	70/263 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158668
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0307
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	678	1.000	Inparanoid score	I721
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54150
OrthoDB	1	1.010	-	-		D100998at2759
OrthoFinder	1	1.000	-	-		FOG0002042
OrthoInspector	1	1.000	-	-		otm41246
orthoMCL	1	0.900	-	-		OOG6_101250
Panther	1	1.100	-	-	LDO	PTHR13923
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2285
SonicParanoid	1	1.000	-	-		X1512
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.800