DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sec31 and sec-31

DIOPT Version :10

Sequence 1:NP_001286215.1 Gene:Sec31 / 35877 FlyBaseID:FBgn0033339 Length:1260 Species:Drosophila melanogaster
Sequence 2:NP_502144.1 Gene:sec-31 / 178060 WormBaseID:WBGene00011338 Length:1083 Species:Caenorhabditis elegans


Alignment Length:1330 Identity:301/1330 - (22%)
Similarity:490/1330 - (36%) Gaps:325/1330 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MKIKELQKTVNIAWSPAQQQQILLAAGTAAQQFDSNANS---------TLELY-----SPNFSDA 51
            |..|...::....|||...|:..|.....||.||..|.|         ..|:|     :||.|.|
 Worm     1 MSSKLYSRSGVFVWSPRGIQKKGLIVADFAQFFDPTATSIEPKIDFLPASEIYEKSNLAPNVSHA 65

  Fly    52 TYDLELRASVSSQYKFQKLIWSPV--GPHPSGLIVGGCEAGQINIYSADKLLAGKE-EPLLKRQD 113
            |           .|:|.:|.|:.:  ..||:|:|.||.|.|.:..:.|||.:..:. |.||.|:|
 Worm    66 T-----------NYRFNELAWTSLCSDAHPNGIIAGGTEDGTVVFFDADKFIKNQSLEVLLSRRD 119

  Fly   114 KHTGAVSGLDFNPFQNNLLASCASESEILIWDLNNPETSMSPGTKTQPLEDVKNVAWNRQVQHIL 178
            .| |.|..:|.:. ....:||.....:||:||..|.:|..|||:...| :.||.:.||.:.:.:.
 Worm   120 HH-GHVLTIDVSR-DGRWMASGGGSGQILLWDCANLKTPFSPGSPNFP-DQVKLLRWNLKNESVF 181

  Fly   179 ASVFSTRCVIWDLRKS-QQIIKLSDSQSRVRWHAIEWHPEAATQVWLASEDDQAPVVQLWDLRYA 242
            ||:.|.|...||||:: ..:::.::... ..|.::.|:|..|:|:.::|:...|.|:|.||.|:.
 Worm   182 ASISSRRVSFWDLRRNGSPVLEFAEIPG-CDWSSLSWNPSDASQLIVSSQSQHASVIQKWDSRFT 245

  Fly   243 TAPAKTYQIHERGVLGMSWCLQDNDLMVSCGKDNRIYCWNPNTKIPEGEILSEVAT-TASWYSDV 306
            :.|.|.|:.|..|:..:.|...|:.|::|.|.|.::..||..|    .|:|..|.: ...|..:|
 Worm   246 STPVKEYRHHNMGITSVDWNKADDRLVISSGCDGQVVIWNHET----SEVLGGVGSLQGDWIRNV 306

  Fly   307 QFCPRNPALIASASLEGAVSIYSLHGGTHHLVQTANKIADSFPGMDQFAQEPIPQQATQVVYHDL 371
            ::....|:..|....:..|.|.||           ..:....||.|..|.....|          
 Worm   307 KWNEEEPSQFAIQYFQHPVQISSL-----------TSLGSPQPGADVLAARISDQ---------- 350

  Fly   372 AHAPKWMKRP-CGVAFGFGGKLVSF--------NGTSKTVKVQQLTTES--ALVDRANALERSLV 425
             ..|.|.:.| .|.:...||:|.:|        ......|:::.:..|:  .:.|.|..|.....
 Worm   351 -FVPAWHRAPLIGSSIALGGRLATFWKSYDAMTQQWHHNVEIETIVPENDVGVNDIAQYLHIKDD 414

  Fly   426 DANYSDYCRQRA----DETPDQHG--RYIWYFIKANFELNPKEEMLNLLGYNKDDIDSKFNKFIK 484
            ..|...|..:||    .:|.::..  |.:|..:.|..|...:.:|||.||.    ::|:..:|.:
 Worm   415 KRNLGWYLHERAYAPSSDTSEEADLTRKVWLILLALQEGAGRTKMLNYLGL----VESQDEEFSE 475

  Fly   485 ETDGNSHSDVDTLTTRI--------STLTHSDS-------SEVECDQSTNYST-DNSQ------- 526
            :...::.|:.:...|.|        |.::.:|:       :.:|...|.|:|| |||.       
 Worm   476 KNAASAVSNPNIQPTAIPDRSARSTSVVSGADTDIDIPEVTVIERCSSVNWSTLDNSGWDLLLHT 540

  Fly   527 -TQDNKFDGNAIDSQNHNDFATPPRPQFKVPSGDHSDSLIAEAILTGNVDAAVELCLEAQRIPEA 590
             .||:......:.|.|.:..|.....|.:.   ||...::.:.....|..:           |.:
 Worm   541 IRQDHLEVIRVLISSNQHVAAMMYAAQHET---DHLAMILDDYNKKFNNSS-----------PLS 591

  Fly   591 LIIASTAGIETLNRTQ-TRYLLQQKNELSHVISALVSRDWLDFVNRCTVDSWKEALVAALKHSER 654
            .||.:.:...:.|:|: |......:.|:|..|.:::.    .|.::    .|.|.|...:.| |.
 Worm   592 SIILALSSSSSANKTEITPSKQSSEQEVSQQIGSILQ----TFPDQ----KWSELLGFIIAH-ES 647

  Fly   655 KVVDICERLGDRLLSECASSAEFTR----NAMLCYICAGSIDKLVTAWYQLKRLEQQNPGYKPNT 715
            ...||      ||.::|.......:    .|.:.::.||.||.|:.|                ||
 Worm   648 NATDI------RLAAKCIGKRWLEQGKPLRACIAFLIAGDIDHLLLA----------------NT 690

  Fly   716 T-ELQDLAEMVMLMCKSLEQQGISVDLAGRFAGFLTEYGGLLASQGALTAALQYITTLGGGAAAS 779
            : .|.|..:..:::.:..:....|..|......|..|    |..|||.:.|...:.....|:|..
 Worm   691 SFTLVDRLKQALILHQVSKGAKYSDGLEKLIMNFANE----LLIQGAGSVAWNLVKWSQNGSAEM 751

  Fly   780 ESDVLQSLRDRINNAVNLDYTQPQAAVAAAPHGYQPTRGRGSFSQPQPSAPMPYGQPPNQYAQPS 844
            :               .|.:|           .|....||.....          |||       
 Worm   752 Q---------------ELQWT-----------CYNVAGGRDCTGD----------QPP------- 773

  Fly   845 WPAQVPPLQTSYPGAQQPQ--APPQIF-NPQPVKPEPLAQPPRPLSNASSSGGPPPAGGASSSGG 906
                ..|...:.|.||||.  .|.:.: .|.|:.|..|.....|.:.:.|...|||...:::...
 Worm   774 ----FNPFDVALPRAQQPPIVQPTRTYQQPAPIPPPNLVNGFNPYNPSHSQCPPPPMDYSNNRRN 834

  Fly   907 SGLSGRSKYVLDPSVAAPTSSYGMPYNPVPAPVPSAVPFGGGGVPGPAPQPASVPTYNSNAFNTN 971
            |.|:                                            |.|.|...|.:.:::  
 Worm   835 SNLT--------------------------------------------PMPPSSTFYQTPSWD-- 853

  Fly   972 PIAAAQPYNPSPLMPAQQNQFVPGVNPIETMPP-PAVPPVIQNVQRNPTPPPGWNDPPALKSSRA 1035
                   :.|.|.|||             .||| ..|.||          .|||||||.:    |
 Worm   854 -------HKPPPTMPA-------------NMPPSKPVAPV----------TPGWNDPPPM----A 884

  Fly  1036 PKPKPVVEPSAAIFHPLF-PVDPNQNQNGYVDPSQYQHAAPLGGVPNTYYNPAAFNNNPQQQQQH 1099
            .||..|.:|...:....: |::..|...|.:...|      |.|....|.|  ...|..|....|
 Worm   885 LKPTTVAQPKQNVMEINWKPIETAQAPGGMMTGQQ------LNGFAGGYQN--VMTNGIQGMSIH 941

  Fly  1100 QQSYLQPQQPAPGIQQPNWQGQQQTIGYTEQPAPIQQQRQPAP----PKEKPPLPEEYIYLQTVL 1160
            .|   |....:.....||        .|.::||.......|||    |:::..:.......|.::
 Worm   942 NQ---QSSAASSAFPSPN--------SYQQRPASAASVVAPAPIQLSPEDEKIIEPINTLAQCII 995

  Fly  1161 EELKNRC-LGATNDPRTKRKFVDVVKRLENLYDCLRDGKLTPTTVQYLNQIVQYIQISDYANAME 1224
            |..:.:. :....|.||:.:        ..|...|...:|:|.:.|:|..:..::.:.....|..
 Worm   996 ENARIQARMEKAQDLRTRIQ--------AELSPRLAANRLSPESKQHLTHMAYFVSMRQIREAQA 1052

  Fly  1225 IHTQIAFGT-DFAQCAGFMQGLKVLLQSAS 1253
            :..|:|..: ||.:.:.|:..||.||..||
 Worm  1053 VVAQMARNSGDFVEISSFLPALKSLLSLAS 1082

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sec31NP_001286215.1 WD40 repeat 11..61 CDD:293791 18/63 (29%)
WD40 repeat 68..114 CDD:293791 17/48 (35%)
WD40 <80..329 CDD:475233 77/251 (31%)
WD40 repeat 119..156 CDD:293791 11/36 (31%)
WD40 repeat 166..202 CDD:293791 11/36 (31%)
WD40 repeat 209..250 CDD:293791 14/40 (35%)
WD40 repeat 256..296 CDD:293791 11/39 (28%)
WD40 repeat 303..328 CDD:293791 4/24 (17%)
ACE1-Sec16-like <570..>690 CDD:449359 23/124 (19%)
PHA03247 <802..1080 CDD:223021 57/282 (20%)
sec-31NP_502144.1 WD40 repeat 71..119 CDD:293791 17/47 (36%)
WD40 <83..308 CDD:441893 75/232 (32%)
WD40 repeat 124..160 CDD:293791 11/36 (31%)
WD40 repeat 169..205 CDD:293791 11/35 (31%)
WD40 repeat 212..253 CDD:293791 14/40 (35%)
WD40 repeat 259..296 CDD:293791 11/40 (28%)
Atrophin-1 <767..>904 CDD:460830 48/237 (20%)

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