DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec31 and sec31b

DIOPT Version :9

Sequence 1:	NP_001286215.1	Gene:	Sec31 / 35877	FlyBaseID:	FBgn0033339	Length:	1260	Species:	Drosophila melanogaster
Sequence 2:	XP_031761362.1	Gene:	sec31b / 100497536	XenbaseID:	XB-GENE-5956591	Length:	1211	Species:	Xenopus tropicalis

Alignment Length:	1338	Identity:	464/1338 - (34%)
Similarity:	703/1338 - (52%)	Gaps:	212/1338 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKIKELQKTVNIAWSPAQQQQILLAAGTAAQQFDS--NANSTLELYSPNFSDATYDLELRASVSS 63
            ||:||::::....||||.|..:.||.||:|||.|:  |.::.||::..:|.|...|::.|.....
Frog     1 MKLKEIERSAVQVWSPASQHPVYLATGTSAQQLDASFNTSAALEIFEVDFGDPHPDMKKRGVYPV 65

  Fly    64 QYKFQKLIWSPVGP---HPSGLIVGGCEAGQINIYSADKLLAGKEEPLLKRQDKHTGAVSGLDFN 125
            ..:|.|::|...|.   ..||:|:||.:.|.|.:|||.|:||.:|||::.:.|||:|.|..||.|
Frog    66 SNRFHKILWGSFGSGLLDSSGIIIGGGDNGVITLYSASKILASEEEPVITKNDKHSGPVRALDLN 130

  Fly   126 PFQNNLLASCASESEILIWDLNNPETSMSPGTKTQPLEDVKNVAWNRQVQHILASVF-STRCVIW 189
            |||||||||.||:||:.||||||....|:||.|.||:||:..|:||:||||||:|.. |.:.|:|
Frog   131 PFQNNLLASGASDSEVFIWDLNNFTVPMTPGAKAQPIEDISAVSWNQQVQHILSSSHPSGKAVVW 195

  Fly   190 DLRKSQQIIKLSDSQSRVRWHAIEWHPEAATQVWLASEDDQAPVVQLWDLRYATAPAKTYQIHER 254
            ||||::.:||:||..:|:....:.||||.|||:.|:||||:.||:|:||||:|::|.|..:.|.|
Frog   196 DLRKNEPVIKVSDHSNRMHCSGMMWHPEIATQLVLSSEDDRLPVIQVWDLRFASSPLKMLENHTR 260

  Fly   255 GVLGMSWCLQDNDLMVSCGKDNRIYCWNPNTKIPEGEILSEVATTASWYSDVQFCPRNPALIASA 319
            |:|.:||...|.:|::|..||:||.||||||    .|::.|:.|...|..|||:|||||::.::|
Frog   261 GILSISWSKDDPELLLSSAKDSRILCWNPNT----SEVVYELPTKNQWCFDVQWCPRNPSVFSAA 321

  Fly   320 SLEGAVSIYSLHGGTHHLVQ--TANKIADSFPGMDQFAQ-EP-----IPQQATQ-VVYHDLAHAP 375
            |.:|.:|:||:.||:...:|  .|:||:.||..:|.|.. :|     :|||..| .|...|...|
Frog   322 SFDGWISVYSVMGGSLEALQRSQADKISLSFNSLDPFGTGQPLPPLQVPQQVAQTTVIPPLKKPP 386

  Fly   376 KWMKRPCGVAFGFGGKLVSFN-----------GTSKTVKVQQLTTESALVDRANALERSLVDANY 429
            ||::||.||:|.||||||||:           .:.:.|.:.|::||...:.|::.|:.:|:..|.
Frog   387 KWIRRPVGVSFAFGGKLVSFDCPKASVQPNQEPSPRRVYISQVSTEKEFLARSSELQAALLSGNL 451

  Fly   430 SDYCRQRADETPDQHGRYIWYFIKANFELNPKEEMLNLLGYNKDDIDSKFNKFIKETDGN--SHS 492
            .:||:.:...:.|.:.:.||.|:|.|||.:.:|:.|.||||:|:::|.|.:..:.|...|  |.|
Frog   452 VNYCQNKVQSSQDVYDKSIWNFLKVNFEQDAREKYLKLLGYSKEELDKKISNALGENFQNKSSPS 516

  Fly   493 DVDTLTTRISTLTHSDSSEVECDQSTNYSTDNSQTQDNKFDGNAIDSQNHNDFAT-PPR--PQFK 554
            :.:.|...|.:::...||                    .|.|....:.:..:|.. ||:  .:|:
Frog   517 EPEDLIQSIQSVSSQGSS--------------------SFTGQTPSTSSSMEFFNLPPQDSAKFE 561

  Fly   555 VPSGDHSDSLIAEAILTGNVDAAVELCLEAQRIPEALIIASTAGIETLNRTQTRYLLQQKNELSH 619
            :|....:|.||::|:|.||.:|||:|||:..|..:|:|:|:..|.:.|..||..|..||||:::.
Frog   562 IPVNSDTDGLISQALLLGNFEAAVDLCLKDGRFADAIILANAGGEDLLRETQQWYFSQQKNKITT 626

  Fly   620 VISALVSRDWLDFVNRCTVDSWKEALVAALKHSE-RKVVDICERLGDRLLSECASSAEFTRNAML 683
            ::|::|...|.|.|.||.:.||||||...|.:|: .:..::|:.||:||  |.....:.:..|.|
Frog   627 LLSSVVQHKWRDIVLRCNLQSWKEALALLLTYSKPEEYAELCDILGNRL--ETEGEGKLSSQACL 689

  Fly   684 CYICAGSIDKLVTAWYQLKRLEQQNPGYKPNTTELQDLAEMVMLMCKSLE-QQGISVDLAGR-FA 746
            |||.:|::::||..|  :|..:..||      ..|||:.|..|::.||:| .:|..:...|. .|
Frog   690 CYISSGNVERLVECW--VKSHDITNP------LALQDIMEKAMVLRKSIEILRGAELPSQGPVMA 746

  Fly   747 GFLTEYGGLLASQGALTAALQYITTLGGGAAASESDVLQSLRDRINNA-----VNLDYTQPQAAV 806
            ..:.||..||||||.|.||:..:.     ..:.|:.|.| ||:|:.||     .:.:.|..::::
Frog   747 EKVAEYANLLASQGNLAAAMSILP-----IDSHETAVCQ-LRNRLLNAQGEGVSSQNSTSHESSI 805

  Fly   807 --------AAAPHGYQPTRGRGSFSQPQ--------PSAPMPYGQPPNQYAQPSWPAQVPPLQT- 854
                    :.||.|.|.: .|.:|||||        |:.|..:...|...| |..|.|..|.||
Frog   806 QPAFGLKGSKAPEGVQYS-NRQTFSQPQAGTGIPIIPAVPSVFTPQPMPTA-PVGPPQAVPFQTV 868

  Fly   855 ------SYP--------GAQQPQAPPQI----FNP--QPVKPEPLAQPPRPLSNASSSGGPPPAG 899
                  |||        .||||..|..:    |.|  .|: |...|.||.|:     :|..||..
Frog   869 PGLPSSSYPRPGAWQTYPAQQPPVPAYVHSSSFKPTGHPL-PNTAALPPSPV-----TGHLPPIS 927

  Fly   900 GASSSGGSGLSGRSKYVLDPSVAAPTSSYGMPYNPVPAPVPSAVPFGGGGVP---GPAPQPASVP 961
            ..:.:|                 .||:| |..:.| ||.|||:||.....|.   .|..||.:.|
Frog   928 SVNLTG-----------------VPTAS-GPMFIP-PASVPSSVPAANQPVSRTFPPMGQPPTPP 973

  Fly   962 TYNSNAFNTNPIAAAQPYNPSPLMPAQQNQFVPGVNPIETMPPP-AVPPVIQNVQRNP--TPPPG 1023
                      .:|::||....| |.|..:...||. |....||| ...|.:|| |:||  :....
Frog   974 ----------GVASSQPPFNYP-MGAGFHHGGPGA-PTSLPPPPTGYFPWLQN-QQNPAASEQEA 1025

  Fly  1024 WNDPPALKSS-RAPKPKPVVEPSAAIFHPLFPVDPNQNQNGYVDPSQYQHAAPLGGVPNTYYNPA 1087
            |:||.|.|:. :..|..||:.|:        |:                 .||:...|.
Frog  1026 WSDPHAFKAGIQRKKSNPVIPPA--------PI-----------------TAPVMNFPT------ 1059

  Fly  1088 AFNNNPQQQQQHQQSYLQPQQPAPGIQQPNWQGQQQTIGYTEQPAPIQQQRQPAPPKEKPPLPEE 1152
                        :...||||..:      ::...|...|..::.:..:..|.|....||..:|.|
Frog  1060 ------------ESEALQPQLSS------SYDFNQAPPGAPKETSMQRMHRLPVEKIEKKEMPLE 1106

  Fly  1153 YIYLQTVLEELKNRCLGATNDPRTKRKFVDVVKRLENLYDCLRDGKLTPTTVQYLNQIVQYIQIS 1217
            :..||...:.|..||....:||:||||..|.::|||.|||.||:..|:|..:..|::|.:.|:..
Frog  1107 HQPLQKSFDGLVQRCSAVASDPKTKRKLEDALQRLECLYDKLRENNLSPHILAGLHEIARCIETR 1171

  Fly  1218 DYANAMEIHTQIAFGTDFAQCAGFMQGLKVLLQSASEL 1255
            :|...:.:|||:...::|::.:.||..||||:..||:|
Frog  1172 NYQQGLVVHTQVVSSSNFSEVSSFMPILKVLMTIASKL 1209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec31	NP_001286215.1	WD40 repeat	11..61	CDD:293791	20/51 (39%)
		WD40	<35..334	CDD:225201	144/304 (47%)
		WD40 repeat	68..114	CDD:293791	19/48 (40%)
		WD40	<80..329	CDD:295369	130/249 (52%)
		WD40 repeat	119..156	CDD:293791	24/36 (67%)
		WD40 repeat	166..202	CDD:293791	19/36 (53%)
		WD40 repeat	209..250	CDD:293791	22/40 (55%)
		WD40 repeat	256..296	CDD:293791	17/39 (44%)
		WD40 repeat	303..328	CDD:293791	12/24 (50%)
		ACE1-Sec16-like	<570..>690	CDD:301350	48/120 (40%)
		RCR	<811..>873	CDD:304939	28/90 (31%)
sec31b	XP_031761362.1	WD40	120..337	CDD:421866	116/220 (53%)
		WD40 repeat	124..161	CDD:293791	24/36 (67%)
		WD40 repeat	171..207	CDD:293791	19/35 (54%)
		WD40 repeat	213..256	CDD:293791	22/42 (52%)
		WD40 repeat	262..300	CDD:293791	18/41 (44%)
		WD40 repeat	305..330	CDD:293791	12/24 (50%)
		PHA03247	<831..1082	CDD:223021	86/338 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	679	1.000	Inparanoid score	I714
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D100998at2759
OrthoFinder	1	1.000	-	-		FOG0002042
OrthoInspector	1	1.000	-	-		otm48455
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1512
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.060