DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sec31 and ankrd40

DIOPT Version :9

Sequence 1:	NP_001286215.1	Gene:	Sec31 / 35877	FlyBaseID:	FBgn0033339	Length:	1260	Species:	Drosophila melanogaster
Sequence 2:	XP_001341377.1	Gene:	ankrd40 / 100005118	ZFINID:	ZDB-GENE-120612-2	Length:	392	Species:	Danio rerio

Alignment Length:	324	Identity:	68/324 - (20%)
Similarity:	117/324 - (36%)	Gaps:	80/324 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   955 PQPASVPTYNSNAFNTNPIAAAQPYNPSPLMPAQQNQFVPGVNPIETMPPPAVPPVIQNVQRNPT 1019
            |:...:|.|.|     ||.......|...|..||||    |.|.....|..:.|..:...|....
Zfish   106 PELPIIPNYLS-----NPPFLYSKMNKDNLSIAQQN----GTNSTHAEPLESEPATLSPTQEQQL 161

  Fly  1020 PPPGWNDPPALKSSRAPKPK----PVVEPSAAIFHPL----FPVDPNQNQNGYVDPSQYQHAAPL 1076
            |.|....|.:|.:....:.:    |.||.:..:..|:    .|::.: ::..:.:..::.||.|:
Zfish   162 PAPSHQQPKSLYTDSQSQQELTFVPGVEQNGVVPSPVVNGGLPMELS-SETHHTNHCEFTHAHPI 225

  Fly  1077 GGVPNTYYNPAAFNNNPQQQQQHQQSYLQPQQPAPGIQQPNWQGQQQTIGYTEQPAPIQQQRQPA 1141
              ..|....|:|..:.|            ||.|...|      .:||:|    ||.....|...:
Zfish   226 --AQNGPVCPSASTSQP------------PQLPGTTI------SRQQSI----QPQINCSQISGS 266

  Fly  1142 PPKEKP-------PLPEEYIYLQTVLEELKNRCLGATNDPRTKRKFVDV-VKRLENLYD-----C 1193
            .|..:|       |:..:.:.|:..::....|    .||      |::| :.|.|..|.     |
Zfish   267 MPAFQPFFFTSTFPVNVQELVLKVRIQNTNIR----END------FIEVELDRQELTYRALLRVC 321

  Fly  1194 LRDGKLTPTTVQYLNQIVQYIQISDYANAMEIHTQIAFGTDFAQCAGFMQGLKVLLQSASELQL 1257
            .|:..::...|:.:.::.              :|.:....|.|:...| |.|:|:|:....|.|
Zfish   322 CRELDISAEHVEKIRKLP--------------NTMLRKDKDVARLQDF-QELEVVLEKTEGLSL 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
Sec31	NP_001286215.1	WD40 repeat	11..61	CDD:293791
		WD40	<35..334	CDD:225201
		WD40 repeat	68..114	CDD:293791
		WD40	<80..329	CDD:295369
		WD40 repeat	119..156	CDD:293791
		WD40 repeat	166..202	CDD:293791
		WD40 repeat	209..250	CDD:293791
		WD40 repeat	256..296	CDD:293791
		WD40 repeat	303..328	CDD:293791
		ACE1-Sec16-like	<570..>690	CDD:301350
		RCR	<811..>873	CDD:304939
ankrd40	XP_001341377.1	ANK	7..>93	CDD:238125
		Ank_4	14..64	CDD:290365
		ANK repeat	14..40	CDD:293786
		ANK repeat	43..74	CDD:293786
		Ank_2	48..>83	CDD:289560
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900