DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8272 and RAD7

DIOPT Version :9

Sequence 1:	NP_001260812.1	Gene:	CG8272 / 35875	FlyBaseID:	FBgn0033337	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_012586.1	Gene:	RAD7 / 853512	SGDID:	S000003813	Length:	565	Species:	Saccharomyces cerevisiae

Alignment Length:	451	Identity:	92/451 - (20%)
Similarity:	171/451 - (37%)	Gaps:	127/451 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 MSGCHIAFHNAIHRRFYPATSSSDHVLPSESVLTFKFILTILNLQRRTLRVLNFSH----TLIGQ 258
            :.|...|..|.:.:......:.:||.|.       .|:.|       .|:.|.||.    :..|.
Yeast   202 LGGVSTANLNNLAKALSKNRALNDHTLQ-------LFLKT-------DLKRLTFSDCSKISFDGY 252

  Fly   259 ALLA-----LCDLNLQLQRLYLAGCRQLNCTTILNFLATQPQLCALDLSATMCVNDENLAA-LVQ 317
            ..||     |.:|:||:       |.|||..::|......|.|.:|:|.....:|::.... .|.
Yeast   253 KTLAIFSPHLTELSLQM-------CGQLNHESLLYIAEKLPNLKSLNLDGPFLINEDTWEKFFVI 310

  Fly   318 TNPQLEHLKVNGCLSITNAGAIHLAKLKC---LKSLDISNCDNLTSSGII-EGIASEENPVIQEL 378
            ...:||...::.....|:....:|. :.|   |.||.:|..|::::..:: :.:.::|
Yeast   311 MKGRLEEFHISNTHRFTDKSLSNLL-INCGSTLVSLGLSRLDSISNYALLPQYLVNDE------- 367

  Fly   379 NVSYLQICEECIKAIASNLRCLRSLHLNHCVN--GATDEAIQSVIGQL-RWLRELSLEHCSGLTD 440
                                 ..||.:.:..|  ...||.|.:::||: |.||:|.|..|..|||
Yeast   368 ---------------------FHSLCIEYPFNEEDVNDEIIINLLGQIGRTLRKLVLNGCIDLTD 411

  Fly   441 AALTGINISKLEMSRKQSGSQVSSMDNFYPPYSNTLAERDSLAGSLQSIKISLRSKAE-DEIVRD 504
            :.:                  ::.:..|.|                :...:.:.|..| |:|..|
Yeast   412 SMI------------------INGLTAFIP----------------EKCPLEVLSLEESDQITTD 442

  Fly   505 ARRKQAMLAAYEMNLIREDDFEGHNIQQLRGLRSLNLRGCNKISDVS----LKYGLKHIELRRLM 565
            :       .:|..:.:           :|..|...:.|.|.::.|::    |..|.:. .||.|.
Yeast   443 S-------LSYFFSKV-----------ELNNLIECSFRRCLQLGDMAIIELLLNGARD-SLRSLN 488

  Fly   566 LSNCQQISLLGMEAMASSCPSIEELDLSDCYNITDKTIQVVTSKLPRLKALHISGCSQLTE 626
            |::.::::.....|:|  ||::..|||.....:.|..||::..:.|.|..:.:.|.:.:||
Yeast   489 LNSLKELTKEAFVALA--CPNLTYLDLGFVRCVDDSVIQMLGEQNPNLTVIDVFGDNLVTE 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8272	NP_001260812.1	AMN1	269..440	CDD:187754	38/178 (21%)
		leucine-rich repeat	270..295	CDD:275381	5/24 (21%)
		leucine-rich repeat	296..319	CDD:275381	5/23 (22%)
		leucine-rich repeat	322..346	CDD:275381	4/23 (17%)
		leucine-rich repeat	347..399	CDD:275381	6/52 (12%)
		leucine-rich repeat	400..426	CDD:275381	8/28 (29%)
		leucine-rich repeat	427..535	CDD:275381	17/108 (16%)
		AMN1	515..>642	CDD:187754	27/116 (23%)
		leucine-rich repeat	536..560	CDD:275381	6/27 (22%)
		leucine-rich repeat	561..586	CDD:275381	7/24 (29%)
		leucine-rich repeat	587..612	CDD:275381	6/24 (25%)
		leucine-rich repeat	613..638	CDD:275381	4/14 (29%)
		leucine-rich repeat	639..663	CDD:275381
		F-box-like	12..>44	CDD:289689
		leucine-rich repeat	129..166	CDD:275381
		leucine-rich repeat	167..192	CDD:275381
		leucine-rich repeat	193..244	CDD:275381	8/45 (18%)
		C2	<231..274	CDD:301316	13/51 (25%)
		leucine-rich repeat	246..269	CDD:275381	9/31 (29%)
RAD7	NP_012586.1	AMN1	228..440	CDD:187754	58/295 (20%)
		leucine-rich repeat	236..261	CDD:275381	7/24 (29%)
		leucine-rich repeat	262..287	CDD:275381	9/31 (29%)
		leucine-rich repeat	288..340	CDD:275381	10/52 (19%)
		leucine-rich repeat	342..365	CDD:275381	5/22 (23%)
		leucine-rich repeat	368..397	CDD:275381	8/28 (29%)
		leucine-rich repeat	398..426	CDD:275381	10/61 (16%)
		leucine-rich repeat	428..455	CDD:275381	7/44 (16%)
		leucine-rich repeat	456..475	CDD:275381	4/18 (22%)
		leucine-rich repeat	484..507	CDD:275381	7/24 (29%)
		leucine-rich repeat	508..533	CDD:275381	6/24 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900