Protein Alignment CG8272 and FBXL20

DIOPT Version :10

• Sequence 1: NP_001260812.1
• Gene: CG8272 / 35875
• FlyBaseID: FBgn0033337
• Length: 710
• Species: Drosophila melanogaster
• Sequence 2: NP_001357137.2
• Gene: FBXL20 / 84961
• HGNCID: 24679
• Length: 438
• Species: Homo sapiens
• Alignment Length: 542
• Identity: 116/542 - (21%)
• Similarity: 204/542 - (37%)
• Gaps: 171/542 - (31%)

  Fly   175 NQYLTDAILMRLTSFMPSLEAINMSGCHIAFHNAIHRRFYPATSSSDHVLPSESVLTFKFILTIL 239
            |:.|...:|:|:.||   |:.:.:..|             ...|.:.:||..:.          .
Human    27 NKKLPKELLLRIFSF---LDVVTLCRC-------------AQVSRAWNVLALDG----------S 65

  Fly   240 NLQRRTLRVLNFSHTLIGQALLALCDLNLQ------LQRLYLAGCRQLNCTTILNFLATQPQLCA 298
            |.||  :.:.:|...:.|:.:     .|:.      |::|.|.||
Human    66 NWQR--IDLFDFQRDIEGRVV-----ENISKRCGGFLRKLSLRGC-------------------- 103

  Fly   299 LDLSATMCVNDENLAALVQTNPQLEHLKVNGCLSITNAGAIHLAKLKC--LKSLDISNCDNLTSS 361
                  :.|.|..|....|....:|.|.:|||...|:|....|:|. |  |:.||:::|.::|:.
Human   104 ------LGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKF-CSKLRHLDLASCTSITNM 161

  Fly   362 GIIEGIASEENPVIQELNVSYL-QICEECIKAIASNLRCLRSLHLNHCVNGATDEAIQSVIGQLR 425
            .:  ...||..|::::||:|:. |:.::.|:|:......|::|.|..|.. ..|||::.:.....
Human   162 SL--KALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQ-LEDEALKYIGAHCP 223

  Fly   426 WLRELSLEHCSGLTDAALTGINISKLEMSRKQSGSQVSSMDNFYPPYSNTLAERDSLAGSLQSIK 490
            .|..|:|:.|..:||..|.
Human   224 ELVTLNLQTCLQITDEGLI---------------------------------------------- 242

  Fly   491 ISLRSKAEDEIVRDARRKQAMLAAYEMNLIREDDFEGHNIQQLRGLRSLNLRGCNKISDVSLK-Y 554
                     .|.|...:.|::.|:                            ||:.|:|..|. .
Human   243 ---------TICRGCHKLQSLCAS----------------------------GCSNITDAILNAL 270

  Fly   555 GLKHIELRRLMLSNCQQISLLGMEAMASSCPSIEELDLSDCYNITDKTIQVVTSKLPRLKALHIS 619
            |.....||.|.::.|.|::.:|...:|.:|..:|::||.:|..|||.|:..::...|||:.|.:|
Human   271 GQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLS 335

  Fly   620 GCSQLTEHTLDAI--ITNCSC----LQTLSIYRCRSMYTDLE-ERLSGVKTLRNLNMDNLTSIDN 677
            .|..:|:   |.|  :.|.:|    |:.:.:..| .:.||.. |.|....:|..:.:.:...|..
Human   336 HCELITD---DGIRHLGNGACAHDQLEVIELDNC-PLITDASLEHLKSCHSLERIELYDCQQITR 396

  Fly   678 AEFFRLKKRLD----YXYFAAI 695
            |...||:..|.    :.|||.:
Human   397 AGIKRLRTHLPNIKVHAYFAPV 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8272	NP_001260812.1	F-box_SF	11..58	CDD:459239
		leucine-rich repeat	129..166	CDD:275381
		leucine-rich repeat	167..192	CDD:275381	6/16 (38%)
		leucine-rich repeat	193..244	CDD:275381	7/50 (14%)
		C2	<231..274	CDD:472691	7/48 (15%)
		leucine-rich repeat	246..269	CDD:275381	3/22 (14%)
		AMN1	269..440	CDD:187754	44/179 (25%)
		leucine-rich repeat	270..295	CDD:275381	5/24 (21%)
		leucine-rich repeat	296..319	CDD:275381	4/22 (18%)
		leucine-rich repeat	322..346	CDD:275381	9/23 (39%)
		leucine-rich repeat	347..399	CDD:275381	14/52 (27%)
		leucine-rich repeat	400..426	CDD:275381	7/25 (28%)
		leucine-rich repeat	427..535	CDD:275381	11/107 (10%)
		AMN1	515..>642	CDD:187754	34/133 (26%)
		leucine-rich repeat	536..560	CDD:275381	6/24 (25%)
		leucine-rich repeat	561..586	CDD:275381	8/24 (33%)
		leucine-rich repeat	587..612	CDD:275381	8/24 (33%)
		leucine-rich repeat	613..638	CDD:275381	8/26 (31%)
		leucine-rich repeat	639..663	CDD:275381	6/24 (25%)
FBXL20	NP_001357137.2	F-box_FBXL2-like	24..68	CDD:438887	12/66 (18%)
		leucine-rich repeat	67..94	CDD:275381	5/33 (15%)
		AMN1	95..291	CDD:187754	62/308 (20%)
		leucine-rich repeat	95..114	CDD:275381	8/44 (18%)
		leucine-rich repeat	121..146	CDD:275381	10/25 (40%)
		leucine-rich repeat	147..172	CDD:275381	7/26 (27%)
		leucine-rich repeat	173..198	CDD:275381	6/24 (25%)
		leucine-rich repeat	199..224	CDD:275381	7/25 (28%)
		AMN1	222..396	CDD:187754	52/260 (20%)
		leucine-rich repeat	225..250	CDD:275381	9/79 (11%)
		leucine-rich repeat	251..276	CDD:275381	8/52 (15%)
		leucine-rich repeat	277..302	CDD:275381	8/24 (33%)
		leucine-rich repeat	303..328	CDD:275381	8/24 (33%)
		leucine-rich repeat	329..357	CDD:275381	9/30 (30%)
		leucine-rich repeat	358..382	CDD:275381	6/24 (25%)
		leucine-rich repeat	383..408	CDD:275381	6/24 (25%)