Protein Alignment CG8272 and FBXL18

DIOPT Version :10

• Sequence 1: NP_001260812.1
• Gene: CG8272 / 35875
• FlyBaseID: FBgn0033337
• Length: 710
• Species: Drosophila melanogaster
• Sequence 2: NP_001308142.1
• Gene: FBXL18 / 80028
• HGNCID: 21874
• Length: 801
• Species: Homo sapiens
• Alignment Length: 780
• Identity: 172/780 - (22%)
• Similarity: 265/780 - (33%)
• Gaps: 256/780 - (32%)

  Fly     2 SGLEYGLH--RYDDLPLEIVLKIFSYLGYSDL-QAAGSTCQRWHAALDQAEFNQRTRVCFSKVVL 63
            :|:..|:|  .:.|   ||:|.|.|::..:|| .....||::..|            :|..|.::
Human    20 AGMADGVHLLGFSD---EILLHILSHVPSTDLILNVRRTCRKLAA------------LCLDKSLI 69

  Fly    64 SDQLSPGVDLMRCERRFQHFLFEDVTLGQVKELMRFMGRTAQSLA-------------------- 108
            ...|        .::.:|  ..||    :|::|::.:||..|.|:
Human    70 HTVL--------LQKDYQ--ASED----KVRQLVKEIGREIQQLSMAGCYWLPGSTVEHVARCRS 120

  Fly   109 -----LDNVDLNDKQFYGMLGVLPHLHSLSLKRCLPLFMSGSFLDSYNNSCPDLNDLAS----NL 164
                 |....|...:...||..|.||.||::.      :|..|         |.:.|:|    .|
Human   121 LVKVNLSGCHLTSLRLSKMLSALQHLRSLAID------VSPGF---------DASQLSSECKATL 170

  Fly   165 AGIKELTLCENQYLTDAILMRLTSFMPSLEAINMSGCHIAFHNAIHRRFYPATSSSDHVLPSESV 229
            :.::||              :.|.|.||...:                  |..:|.:.:|
Human   171 SRVREL--------------KQTLFTPSYGVV------------------PCCTSLEKLL----- 198

  Fly   230 LTFKFILTILNLQRRTLRVLNFSHTLIGQ-------------ALLALCDLNLQLQRLYLAGCRQL 281
            |.|:.      |.|.....:.....::||             |.||...:|.::.|||||.....
Human   199 LYFEI------LDRTREGAILSGQLMVGQSNVPHYQNLRVFYARLAPGYINQEVVRLYLAVLSDR 257

  Fly   282 NCTTILNFLATQPQLCA--------LDLSATMCVNDENLAAL------VQTNPQLEHLKVNG--- 329
            ....:..||.:.|...|        ||..|...|.|    ||      :..:..|:|:|.|.
Human   258 TPQNLHAFLISVPGSFAESGATKNLLDSMARNVVLD----ALQLPKSWLNGSSLLQHMKFNNPFY 318

  Fly   330 -----CLSITNAGAIHLAK--------LKCLKSLDISNCDNLTSSGIIEGIASEENPVIQELNVS 381
                 |   |.:|. ||.:        |:.|.||::|.|.:..|...:...|.:      :::.|
Human   319 FSFSRC---TLSGG-HLIQQVINGGKDLRSLASLNLSGCVHCLSPDSLLRKAED------DIDSS 373

  Fly   382 YLQICEECIKAIASNLRCLRSLHLN------HCVNGATDEAIQSVIGQLRWLRELSLEHCS---- 436
            .|    |.:.|...|||     |||      |...|......| ::.:||.||.|||..||
Human   374 IL----ETLVASCCNLR-----HLNLSAAHHHSSEGLGRHLCQ-LLARLRHLRSLSLPVCSVADS 428

  Fly   437 ------------------GLTDAALTGINISKLEMSRKQSGSQVSSMDNFYPPYSN-TLAERDSL 482
                              |.......|:.......| .|:..|.||:  |:....| ...|...|
Human   429 APRADRAPAQPAMHAVPRGFGKKVRVGVQSCPSPFS-GQACPQPSSV--FWSLLKNLPFLEHLEL 490

  Fly   483 AGSLQSIKISLRSKAEDEIVRDARRKQAMLAAYEMNLIREDDFEGHNIQQLRGLRSLNLRGCNKI 547
            .||..|..:.....|....:....|.|::           .|.|...|.||..||.|.|.....:
Human   491 IGSNFSSAMPRNEPAIRNSLPPCSRAQSV-----------GDSEVAAIGQLAFLRHLTLAQLPSV 544

  Fly   548 SDVS--LKYGLKHIELRRLMLSNCQQISLLG-------MEAMASSCPSIEELDLSDCYNITDKTI 603
            ...|  :..||:..:||.|.|:|   :.::|       :..|...|..:.:|.|...|...:...
Human   545 LTGSGLVNIGLQCQQLRSLSLAN---LGMMGKVVYMPALSDMLKHCKRLRDLRLEQPYFSANAQF 606

  Fly   604 QVVTSKLPRLKALHISGCSQLTEHTL--DAIIT-NCSCLQTL--------SIYRCRSMYTDLEER 657
            ....|:.|.|:.|    |......||  ||::. ...|||.:        |:..|:|:...|..|
Human   607 FQALSQCPSLQRL----CLVSRSGTLQPDAVLAFMARCLQVVMCHLFTGESLATCKSLQQSLLRR 667

  Fly   658  657
            Human   668  667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8272	NP_001260812.1	F-box_SF	11..58	CDD:459239	11/47 (23%)
		leucine-rich repeat	129..166	CDD:275381	9/40 (23%)
		leucine-rich repeat	167..192	CDD:275381	4/24 (17%)
		leucine-rich repeat	193..244	CDD:275381	6/50 (12%)
		C2	<231..274	CDD:472691	10/55 (18%)
		leucine-rich repeat	246..269	CDD:275381	6/35 (17%)
		AMN1	269..440	CDD:187754	56/228 (25%)
		leucine-rich repeat	270..295	CDD:275381	7/24 (29%)
		leucine-rich repeat	296..319	CDD:275381	8/36 (22%)
		leucine-rich repeat	322..346	CDD:275381	10/39 (26%)
		leucine-rich repeat	347..399	CDD:275381	13/51 (25%)
		leucine-rich repeat	400..426	CDD:275381	7/31 (23%)
		leucine-rich repeat	427..535	CDD:275381	29/130 (22%)
		AMN1	515..>642	CDD:187754	35/138 (25%)
		leucine-rich repeat	536..560	CDD:275381	7/25 (28%)
		leucine-rich repeat	561..586	CDD:275381	8/31 (26%)
		leucine-rich repeat	587..612	CDD:275381	4/24 (17%)
		leucine-rich repeat	613..638	CDD:275381	7/27 (26%)
		leucine-rich repeat	639..663	CDD:275381	7/27 (26%)
FBXL18	NP_001308142.1	F-box_FBXL18	28..71	CDD:438900	13/57 (23%)
		FBXL18_LRR	85..678	CDD:466163	152/686 (22%)
		leucine-rich repeat	345..384	CDD:275381	11/48 (23%)
		leucine-rich repeat	385..414	CDD:275381	9/34 (26%)
		leucine-rich repeat	415..484	CDD:275381	16/71 (23%)
		leucine-rich repeat	451..476	CDD:275381	6/27 (22%)
		leucine-rich repeat	485..532	CDD:275381	13/57 (23%)
		leucine-rich repeat	533..559	CDD:275381	7/25 (28%)
		leucine-rich repeat	560..589	CDD:275381	8/31 (26%)
		leucine-rich repeat	590..615	CDD:275381	4/24 (17%)
		leucine-rich repeat	616..640	CDD:275381	7/27 (26%)