DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8272 and lrrc29

DIOPT Version :9

Sequence 1:	NP_001260812.1	Gene:	CG8272 / 35875	FlyBaseID:	FBgn0033337	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	XP_001339819.4	Gene:	lrrc29 / 799466	ZFINID:	ZDB-GENE-030131-7165	Length:	644	Species:	Danio rerio

Alignment Length:	680	Identity:	186/680 - (27%)
Similarity:	307/680 - (45%)	Gaps:	88/680 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LHRYDDLPLEIVLKIFSYLGYSDLQAAGSTCQRWHAALDQAEFNQRTRVCFSKVVLSDQLS---- 68
            ||    ||.||:..|||:|...|.:.|...|:.|:.|.....|  :..:.|.....|..|.
Zfish     4 LH----LPSEIITYIFSFLHVMDRKEASLVCKSWYNASQDYPF--KRNLTFKFPASSSSLGFIRG 62

  Fly    69 ----PGVDLMRCERRFQHFLFEDVTLGQVKELMRFMGRTAQSLALDNVDLNDKQFYGMLGVLPHL 129
                |     ||.....|.....|:...:.|:...:|....||||....:.:.....:|..|..|
Zfish    63 LARHP-----RCGLVISHLDGSSVSRQVLLEVGLHLGPRLDSLALPGSSITESCLLELLPRLTSL 122

  Fly   130 HSLSLKRCLPLFMSGSFLDSYNNSCPDLNDLASNLAGIKELTLCENQYLTDAILMRLTSFMPSLE 194
            ..|.|:....|||||:||....:.    ..:...|..::||.|...:||:|....|||...|.|.
Zfish   123 RKLDLQGLDSLFMSGAFLSREEHR----RKVYRALLNLEELNLSNLRYLSDLSFNRLTICTPGLR 183

  Fly   195 AINMSGCHIAFHNAIHRRFYPATSSSDHVLPSESVLTFKFILTILNLQRRTLRVLNFSHT-LIGQ 258
            .:::|||||:|....:|.....:.||       ::::.:.:|.:|..|..|||.|:.|.| :..:
Zfish   184 RLSLSGCHISFEFDPYRGCPVGSGSS-------ALVSLRNLLNLLQKQTSTLRSLDLSRTGITPK 241

  Fly   259 ALLALCDL-NLQLQRLYLAGCRQLNCTTILNFLATQPQLCALDLSATMCVNDENLAALVQTNPQL 322
            :|.::..| .|:|:.|.|.||::|...:|......|..|..||||..|   :.:..|::....:|
Zfish   242 SLRSISKLRGLRLEELNLHGCKELTDYSIEILCKYQSGLRMLDLSGCM---ELSCRAVLAVGAEL 303

  Fly   323 EHLKVNGCLS------ITNAGAIHLAKLKCLKSLDISNCDNLTSSGIIEGIAS-EENPVIQEL-- 378
            :.|:|   ||      ||:.|...|..|..|:|||:|.|.:::.:.:::|::. |....::.|
Zfish   304 KELRV---LSFSQDWKITDKGLAELMMLPHLRSLDLSECLHVSGTELVKGLSGPEPRAQVETLSL 365

  Fly   379 -NVSYLQICEECIKAIASNLRC-LRSLHLNHCVNGATDEAIQSVIGQLRWLRELSLEHCSGLTDA 441
             |.:|::  :..:.::|..|.. ||.|.|:.||. .||.:::::...|..|..|.|..|..::|.
Zfish   366 RNCTYIR--DSVVFSLAQLLGVHLRELDLSSCVY-LTDLSVRAIATFLPALLVLRLGWCKEISDW 427

  Fly   442 ALTGINISKLEMSRKQSGSQVSSM-DNFYPPYSNTLAERDSLAGSLQSIKISLRSK---AEDEIV 502
            .|.|       |:......|.|.. ::..|.::.|...    .|..|...:..:.|   ..||.:
Zfish   428 GLLG-------MTEPTKHCQPSDREEDKGPSFTRTFGN----MGFFQPPSLPFQDKPRLVTDEDL 481

  Fly   503 RDARRKQAMLAAYEMNLIREDDFEGHNIQQLRGLRSLNLRGCNKISDVSLKYGLKHIELRRLMLS 567
            .:.|                 |.:|.::..||.|:.|.|..|:|::|.|:...|:..||:||.||
Zfish   482 EEFR-----------------DQQGASLLALRELQVLELTACSKLTDTSITQVLRFPELQRLSLS 529

  Fly   568 NCQQISLLGMEAMASSCPSIEELDLSDCYNITDKTIQVVTSKLPRLKALHISGCSQLTEHTLDAI 632
            ...:|:...:.::|..|.|:..|.||.|..|:||.:......|.||:.|:::.|:.:|..||..|
Zfish   530 MLPEITDDSLVSVALHCCSLTSLSLSHCPQISDKGMARALPLLHRLQHLYLACCNAITNETLSII 594

  Fly   633 ITNCSCLQTLSIYRCRSMYTD----LEERL 658
            ..:|..|:||.:..|:.:...    |:.||
Zfish   595 ALHCDRLRTLDVSMCKDITVHQVDLLQSRL 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8272	NP_001260812.1	AMN1	269..440	CDD:187754	51/181 (28%)
		leucine-rich repeat	270..295	CDD:275381	8/24 (33%)
		leucine-rich repeat	296..319	CDD:275381	7/22 (32%)
		leucine-rich repeat	322..346	CDD:275381	10/29 (34%)
		leucine-rich repeat	347..399	CDD:275381	13/55 (24%)
		leucine-rich repeat	400..426	CDD:275381	9/25 (36%)
		leucine-rich repeat	427..535	CDD:275381	21/111 (19%)
		AMN1	515..>642	CDD:187754	40/126 (32%)
		leucine-rich repeat	536..560	CDD:275381	8/23 (35%)
		leucine-rich repeat	561..586	CDD:275381	8/24 (33%)
		leucine-rich repeat	587..612	CDD:275381	8/24 (33%)
		leucine-rich repeat	613..638	CDD:275381	8/24 (33%)
		leucine-rich repeat	639..663	CDD:275381	7/24 (29%)
		F-box-like	12..>44	CDD:289689	12/31 (39%)
		leucine-rich repeat	129..166	CDD:275381	11/36 (31%)
		leucine-rich repeat	167..192	CDD:275381	9/24 (38%)
		leucine-rich repeat	193..244	CDD:275381	13/50 (26%)
		C2	<231..274	CDD:301316	13/44 (30%)
		leucine-rich repeat	246..269	CDD:275381	7/24 (29%)
lrrc29	XP_001339819.4	F-box-like	4..49	CDD:289689	16/50 (32%)
		leucine-rich repeat	71..96	CDD:275381	4/24 (17%)
		leucine-rich repeat	97..121	CDD:275381	6/23 (26%)
		leucine-rich repeat	122..179	CDD:275381	20/60 (33%)
		leucine-rich repeat	182..227	CDD:275381	13/51 (25%)
		AMN1	215..427	CDD:187754	63/220 (29%)
		leucine-rich repeat	228..253	CDD:275381	7/24 (29%)
		leucine-rich repeat	254..277	CDD:275381	7/22 (32%)
		leucine-rich repeat	280..305	CDD:275381	8/27 (30%)
		leucine-rich repeat	306..325	CDD:275381	7/21 (33%)
		leucine-rich repeat	331..359	CDD:275381	8/27 (30%)
		leucine-rich repeat	360..386	CDD:275381	5/27 (19%)
		leucine-rich repeat	387..412	CDD:275381	9/25 (36%)
		leucine-rich repeat	413..497	CDD:275381	21/111 (19%)
		AMN1	<498..613	CDD:187754	39/114 (34%)
		leucine-rich repeat	498..522	CDD:275381	8/23 (35%)
		leucine-rich repeat	523..548	CDD:275381	8/24 (33%)
		leucine-rich repeat	549..574	CDD:275381	8/24 (33%)
		leucine-rich repeat	575..598	CDD:275381	7/22 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587971
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H133339
Inparanoid	1	1.050	181	1.000	Inparanoid score	I3979
OMA	1	1.010	-	-		QHG46839
OrthoDB	1	1.010	-	-		D161790at33208
OrthoFinder	1	1.000	-	-		FOG0003012
OrthoInspector	1	1.000	-	-		oto39054
orthoMCL	1	0.900	-	-		OOG6_109891
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.710