Protein Alignment CG8272 and SKP2

DIOPT Version :10

• Sequence 1: NP_001260812.1
• Gene: CG8272 / 35875
• FlyBaseID: FBgn0033337
• Length: 710
• Species: Drosophila melanogaster
• Sequence 2: NP_005974.2
• Gene: SKP2 / 6502
• HGNCID: 10901
• Length: 424
• Species: Homo sapiens
• Alignment Length: 376
• Identity: 82/376 - (21%)
• Similarity: 138/376 - (36%)
• Gaps: 84/376 - (22%)

  Fly    11 YDDLPLEIVLKIFSYLGYSDLQAAGSTCQRWHAALDQAEFNQRTRVCFSKV---VLSDQLSPGVD 72
            :|.||.|::|.|||.|...:|......|:||:.........|...:....:   |....||.||.
Human    97 WDSLPDELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVI 161

  Fly    73 LMRCERRFQHFLFEDVTLGQVKELMRFMGRTAQSLALDNVDLNDKQFYGMLGVLPHLHSLSLKRC 137
            ..||.|.|.     |..|.:     .|.....|.:.|.|..:.....:|:|.....|.:||
Human   162 AFRCPRSFM-----DQPLAE-----HFSPFRVQHMDLSNSVIEVSTLHGILSQCSKLQNLS---- 212

  Fly   138 LPLFMSGSFLDSYNNSCPDLNDLASNLAGIKELTLCENQYLTDAILMRLTSFMPSLEAINMSGCH 202
                     |:....|.|.:|.||.| :.:..|.|......::..|..|.|....|:.:|:|.|
Human   213 ---------LEGLRLSDPIVNTLAKN-SNLVRLNLSGCSGFSEFALQTLLSSCSRLDELNLSWC- 266

  Fly   203 IAFHNAIHRRFYPATSSSDHVLPSESVLTFKFILTILNLQRRTLRVLNFSHTLIGQALLALCDLN 267
                                           |..|..::|                  :|:..::
Human   267 -------------------------------FDFTEKHVQ------------------VAVAHVS 282

  Fly   268 LQLQRLYLAGCRQ-LNCTTILNFLATQPQLCALDLSATMCVNDENLAALVQTNPQLEHLKVNGCL 331
            ..:.:|.|:|.|: |..:.:...:...|.|..||||.::.:.::......|.| .|:||.::.|.
Human   283 ETITQLNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLN-YLQHLSLSRCY 346

  Fly   332 SITNAGAIHLAKLKCLKSLDISNCDNLTSSGIIEGIASEENPVIQELNVSY 382
            .|.....:.|.::..||:|.:.   .:...|.:: :..|..|.:| :|.|:
Human   347 DIIPETLLELGEIPTLKTLQVF---GIVPDGTLQ-LLKEALPHLQ-INCSH 392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8272	NP_001260812.1	F-box_SF	11..58	CDD:459239	14/46 (30%)
		leucine-rich repeat	129..166	CDD:275381	10/36 (28%)
		leucine-rich repeat	167..192	CDD:275381	5/24 (21%)
		leucine-rich repeat	193..244	CDD:275381	7/50 (14%)
		C2	<231..274	CDD:472691	4/42 (10%)
		leucine-rich repeat	246..269	CDD:275381	1/22 (5%)
		AMN1	269..440	CDD:187754	28/115 (24%)
		leucine-rich repeat	270..295	CDD:275381	5/25 (20%)
		leucine-rich repeat	296..319	CDD:275381	6/22 (27%)
		leucine-rich repeat	322..346	CDD:275381	6/23 (26%)
		leucine-rich repeat	347..399	CDD:275381	9/36 (25%)
		leucine-rich repeat	400..426	CDD:275381
		leucine-rich repeat	427..535	CDD:275381
		AMN1	515..>642	CDD:187754
		leucine-rich repeat	536..560	CDD:275381
		leucine-rich repeat	561..586	CDD:275381
		leucine-rich repeat	587..612	CDD:275381
		leucine-rich repeat	613..638	CDD:275381
		leucine-rich repeat	639..663	CDD:275381
SKP2	NP_005974.2	Mediates interaction with hepatitis C virus non-structural protein NS5A. /evidence=ECO:0000269|PubMed:27194766	1..220		35/145 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	39..73
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:22770219	67..73
		F-box_FBXL1	97..137	CDD:438886	13/39 (33%)
		leucine-rich repeat	183..207	CDD:275381	5/23 (22%)
		AMN1	193..>345	CDD:187754	41/216 (19%)
		leucine-rich repeat	208..231	CDD:275381	10/36 (28%)
		LRR 3. /evidence=ECO:0000269|PubMed:11099048	210..234		9/37 (24%)
		leucine-rich repeat	232..257	CDD:275381	5/24 (21%)
		LRR 4. /evidence=ECO:0000269|PubMed:11099048	235..257		5/21 (24%)
		leucine-rich repeat	258..284	CDD:275381	8/75 (11%)
		LRR 5. /evidence=ECO:0000269|PubMed:11099048	258..284		8/75 (11%)
		leucine-rich repeat	285..311	CDD:275381	5/25 (20%)
		LRR 6. /evidence=ECO:0000269|PubMed:11099048	286..308		5/21 (24%)
		LRR 7. /evidence=ECO:0000269|PubMed:11099048	309..330		6/20 (30%)
		leucine-rich repeat	312..336	CDD:275381	7/24 (29%)
		LRR 8. /evidence=ECO:0000269|PubMed:11099048	334..356		6/22 (27%)
		leucine-rich repeat	337..356	CDD:275381	5/18 (28%)
		LRR 9. /evidence=ECO:0000269|PubMed:11099048	359..378		4/22 (18%)
		leucine-rich repeat	365..392	CDD:275381	6/31 (19%)
		LRR 10. /evidence=ECO:0000269|PubMed:11099048	380..401		5/14 (36%)
		Mediates interaction with IFI27. /evidence=ECO:0000269|PubMed:27194766	402..424