Protein Alignment CG8272 and FBXL17

DIOPT Version :10

• Sequence 1: NP_001260812.1
• Gene: CG8272 / 35875
• FlyBaseID: FBgn0033337
• Length: 710
• Species: Drosophila melanogaster
• Sequence 2: XP_005272105.1
• Gene: FBXL17 / 64839
• HGNCID: 13615
• Length: 712
• Species: Homo sapiens
• Alignment Length: 399
• Identity: 90/399 - (22%)
• Similarity: 159/399 - (39%)
• Gaps: 90/399 - (22%)

  Fly   131 SLSL-KRCLPLFMSGSFLDSYNNSCPDLNDLASNLAGIKELTLCENQYLTDAILMRLTSFMPSLE 194
            :||| :|||    |.|.:      |....||..:....|:|.|...|.:||.:|.::.|...::.
Human   335 NLSLDERCL----SASLV------CKYWRDLCLDFQFWKQLDLSSRQQVTDELLEKIASRSQNII 389

  Fly   195 AINMSGCHIAFHNAI-----------HRRFYPATSSSD----------------HVLPSESVLTF 232
            .||:|.|.....|.:           ....|.....||                || .::..||.
Human   390 EINISDCRSMSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHV-GNQDKLTD 453

  Fly   233 KFILTILNLQRRTLRVLNFS--HTLIGQALLALCDLNLQLQRLYLAGCRQLNCTTILNFLATQPQ 295
            :. |..|..:.|.|:.::|.  :.:..:.::.:....|:|||:|
Human   454 EG-LKQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIY--------------------- 496

  Fly   296 LCALDLSATMCVNDENLAALVQTNPQLEHLKVNGCLSITNAGAIHLAKLKCLKSLDISNCDNLTS 360
                 :.....|.|:::.|..:..|:|:::...|| |:|:.|.|||.||:.|.|||:.:...|.:
Human   497 -----MQENKLVTDQSVKAFAEHCPELQYVGFMGC-SVTSKGVIHLTKLRNLSSLDLRHITELDN 555

  Fly   361 SGIIEGIASEENPVIQEL-NVSYLQIC------EECIKAIASNLRCLRSLHLNHCVNGATDEAIQ 418
            ..::|        :::.. |:|.|.:|      :.|::.||...:.|:.|:|..|  ..||.|:.
Human   556 ETVME--------IVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSC--KITDYALI 610

  Fly   419 SVIGQLRWLRELSLEHCSGLTDAALTGINISKLEMSRKQSGSQVSSMDNFYPPYSNTLAERDSLA 483
            ::......:..:.:..|..:||...|  .|::...|.:..|  :...|.....|........|:.
Human   611 AIGRYSMTIETVDVGWCKEITDQGAT--LIAQSSKSLRYLG--LMRCDKVRVDYQVVCFLHISIV 671

  Fly   484 GSLQSIKIS 492
            .||.|..:|
Human   672 NSLMSYPLS 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8272	NP_001260812.1	F-box_SF	11..58	CDD:459239
		leucine-rich repeat	129..166	CDD:275381	11/35 (31%)
		leucine-rich repeat	167..192	CDD:275381	8/24 (33%)
		leucine-rich repeat	193..244	CDD:275381	14/77 (18%)
		C2	<231..274	CDD:472691	10/44 (23%)
		leucine-rich repeat	246..269	CDD:275381	2/24 (8%)
		AMN1	269..440	CDD:187754	40/177 (23%)
		leucine-rich repeat	270..295	CDD:275381	4/24 (17%)
		leucine-rich repeat	296..319	CDD:275381	3/22 (14%)
		leucine-rich repeat	322..346	CDD:275381	11/23 (48%)
		leucine-rich repeat	347..399	CDD:275381	13/58 (22%)
		leucine-rich repeat	400..426	CDD:275381	7/25 (28%)
		leucine-rich repeat	427..535	CDD:275381	14/66 (21%)
		AMN1	515..>642	CDD:187754
		leucine-rich repeat	536..560	CDD:275381
		leucine-rich repeat	561..586	CDD:275381
		leucine-rich repeat	587..612	CDD:275381
		leucine-rich repeat	613..638	CDD:275381
		leucine-rich repeat	639..663	CDD:275381
FBXL17	XP_005272105.1	F-box_FBXO13	320..368	CDD:438864	13/42 (31%)
		leucine-rich repeat	362..387	CDD:275381	8/24 (33%)
		leucine-rich repeat	388..413	CDD:275381	5/24 (21%)
		AMN1	411..573	CDD:187754	41/198 (21%)
		leucine-rich repeat	414..439	CDD:275381	3/24 (13%)
		leucine-rich repeat	440..465	CDD:275381	6/26 (23%)
		leucine-rich repeat	466..491	CDD:275381	2/24 (8%)
		leucine-rich repeat	492..517	CDD:275381	7/50 (14%)
		leucine-rich repeat	518..541	CDD:275381	11/23 (48%)
		leucine-rich repeat	542..567	CDD:275381	6/32 (19%)
		leucine-rich repeat	568..593	CDD:275381	6/24 (25%)
		leucine-rich repeat	594..615	CDD:275381	7/22 (32%)
		leucine-rich repeat	619..641	CDD:275381	5/23 (22%)