DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8272 and fbxl3

DIOPT Version :9

Sequence 1:	NP_001260812.1	Gene:	CG8272 / 35875	FlyBaseID:	FBgn0033337	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_001016128.1	Gene:	fbxl3 / 548882	XenbaseID:	XB-GENE-1014531	Length:	433	Species:	Xenopus tropicalis

Alignment Length:	498	Identity:	99/498 - (19%)
Similarity:	159/498 - (31%)	Gaps:	167/498 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 HRYDDLPLEIVLKIFSYLGYSDLQAAGSTCQRWHAALDQAEFNQRTRVCFSKVVLSDQLSPGVDL 73
            |.:.:|..:|:|:||.||...|...|...|:.|:......                       ||
Frog    39 HDWGNLLPDIILQIFQYLPLLDRAHASQVCRNWNHVFHMP-----------------------DL 80

  Fly    74 MRCERRFQHFLFEDVTLGQVKELMRFMGRTAQSLALDNVDLNDKQFYGMLGVLPHLHSLSLKRCL 138
            .||   |:..|.:..|        .::..|...|....:..:..          ||..:|.|
Frog    81 WRC---FEFELNQPAT--------SYLNATHPDLIKQIIKRHSN----------HLQYVSFK--- 121

  Fly   139 PLFMSGSFLDSYNNSCPDLNDLASNLAGIKELTLCENQYLTDAILMRLTSFMPSLEAINMSGCHI 203
                    :||...|.....|:.|.|......||       ..|.....|||...::..:|...:
Frog   122 --------VDSSKESAEAACDILSQLVNCSLKTL-------GLISTARPSFMDLPKSHFISALTV 171

  Fly   204 AFHNAIHRRFYPATSSSDHVLPSESVLTFKFILTILNLQRRTLRVLNFSHTLIGQALLALCDLNL 268
            .|.|                  |:|:.:.|...|.::.....:.|.|.|.|
Frog   172 VFVN------------------SKSLSSLKIDDTPVDDPSLKVLVANNSDT-------------- 204

  Fly   269 QLQRLYLAGCRQLNCTTILNFLATQPQLCALDLSATMC------------VNDENLAAL-VQTNP 320
             |:.|.::.|..::...|         ||..|    .|            ::||.|.|| .:.:.
Frog   205 -LKLLKMSSCPHVSPAGI---------LCVAD----QCHGLRELALNYYLLSDELLIALSSEKHV 255

  Fly   321 QLEHLKVNGCLSITNAGAIHLAKLKCLKSLDISNCDNLTSSG-----IIEGIASEE--NPVIQ-E 377
            :||||:::  :...|.|...      ..::..|:.|.|....     ::.....||  :|..: |
Frog   256 RLEHLRID--VVSENPGQTQ------FHTIQKSSWDALIKHSPKVNLVMYFFLYEEEFDPFFRYE 312

  Fly   378 LNVSYLQICEECIKAIAS--NLRCLRSLHLNHCVNG--ATDEAIQSVIGQLRWLRELSLEHCSGL 438
            ..|::|.......|.:..  .:.|.|.:.|..|.||  ..||.:..:           .|.|.
Frog   313 TPVTHLYFGRSVSKEVLGRVGMTCPRLVELVVCANGLRPLDEELIRI-----------AERCK-- 364

  Fly   439 TDAALTGINISKLEMS-------RKQSG---SQVSSMDNFYPP 471
               :||.|.:.:.|:|       .|..|   ||:|.|:....|
Frog   365 ---SLTAIGLGECEVSCSAFVEFVKMCGGRLSQLSIMEEVLIP 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8272	NP_001260812.1	AMN1	269..440	CDD:187754	39/195 (20%)
		leucine-rich repeat	270..295	CDD:275381	4/24 (17%)
		leucine-rich repeat	296..319	CDD:275381	9/35 (26%)
		leucine-rich repeat	322..346	CDD:275381	6/23 (26%)
		leucine-rich repeat	347..399	CDD:275381	10/61 (16%)
		leucine-rich repeat	400..426	CDD:275381	7/27 (26%)
		leucine-rich repeat	427..535	CDD:275381	14/55 (25%)
		AMN1	515..>642	CDD:187754
		leucine-rich repeat	536..560	CDD:275381
		leucine-rich repeat	561..586	CDD:275381
		leucine-rich repeat	587..612	CDD:275381
		leucine-rich repeat	613..638	CDD:275381
		leucine-rich repeat	639..663	CDD:275381
		F-box-like	12..>44	CDD:289689	11/31 (35%)
		leucine-rich repeat	129..166	CDD:275381	9/36 (25%)
		leucine-rich repeat	167..192	CDD:275381	6/24 (25%)
		leucine-rich repeat	193..244	CDD:275381	7/50 (14%)
		C2	<231..274	CDD:301316	7/42 (17%)
		leucine-rich repeat	246..269	CDD:275381	4/22 (18%)
fbxl3	NP_001016128.1	F-box-like	41..82	CDD:403981	13/63 (21%)
		leucine-rich repeat	179..204	CDD:275381	5/24 (21%)
		leucine-rich repeat	205..230	CDD:275381	8/37 (22%)
		leucine-rich repeat	231..256	CDD:275381	5/24 (21%)
		leucine-rich repeat	257..293	CDD:275381	9/43 (21%)
		leucine-rich repeat	294..338	CDD:275381	8/43 (19%)
		leucine-rich repeat	339..365	CDD:275381	8/41 (20%)
		leucine-rich repeat	366..391	CDD:275381	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910