Protein Alignment CG8272 and FBXL12

DIOPT Version :9

• Sequence 1: NP_001260812.1
• Gene: CG8272 / 35875
• FlyBaseID: FBgn0033337
• Length: 710
• Species: Drosophila melanogaster
• Sequence 2: XP_016882401.1
• Gene: FBXL12 / 54850
• HGNCID: 13611
• Length: 343
• Species: Homo sapiens
• Alignment Length: 381
• Identity: 72/381 - (18%)
• Similarity: 129/381 - (33%)
• Gaps: 163/381 - (42%)

  Fly   265 DLNLQLQ--------RLYLAGCRQLNCTTILNFLATQPQLCALDLSATMCVNDENLAALVQTNPQ 321
            |.:||::        |.|:|.  :|:...:..:|.:..|  |..||..:      |.||.|..|.
Human    66 DPHLQMRPKVMWHLLRRYMAS--RLHSLRMGGYLFSGSQ--APQLSPAL------LRALGQKCPN 120

  Fly   322 LEHLKVNGCLSITNAGAIHLAKL-KCLKSLDISNCDNLTSSGIIEGIASEENPVIQELNVSYLQI 385
            |:.|    ||.:.:...:.:..| ..|::|::.:|:.     .:..:..:::|.:..|
Human   121 LKRL----CLHVADLSMVPITSLPSTLRTLELHSCEI-----SMAWLHKQQDPTVLPL------- 169

  Fly   386 CEECIKAIASNLRCLRSLHLNHCVNGATDEAIQSVIGQLRWLRELSLEHCSGLTDAALTGINISK 450
             .|||  :...:...|..||    .|.|         :.|.||.|.|.....:|:   ||::
Human   170 -LECI--VLDRVPAFRDEHL----QGLT---------RFRALRSLVLGGTYRVTE---TGLD--- 212

  Fly   451 LEMSRKQSGSQVSSMDNFYPPYSNTLAERDSLAGSLQSIKISLRSKAEDEIVRDARRKQAMLAAY 515
                                            ||
Human   213 --------------------------------AG------------------------------- 214

  Fly   516 EMNLIREDDFEGHNIQQLRGLRSLNLRGCNKISDVSLKYGLKHI-ELRRLMLS----NCQQISLL 575
                          :|:|..|:.|.:.||...:|.:|....:|: ::|::.|:    :...:::|
Human   215 --------------LQELSYLQRLEVLGCTLSADSTLLAISRHLRDVRKIRLTVRGLSAPGLAVL 265

  Fly   576 -GMEAMASSC----------PSIEELDLSDCYNITDKTIQVVTSKLPRLKALHISG 620
             ||.|:.|.|          ||..|: ||.|..            :|:|:.|.:.|
Human   266 EGMPALESLCLQGPLVTPEMPSPTEI-LSSCLT------------MPKLRVLELQG 308

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8272	NP_001260812.1	AMN1	269..440	CDD:187754	38/179 (21%)
		leucine-rich repeat	270..295	CDD:275381	5/32 (16%)
		leucine-rich repeat	296..319	CDD:275381	7/22 (32%)
		leucine-rich repeat	322..346	CDD:275381	5/24 (21%)
		leucine-rich repeat	347..399	CDD:275381	8/51 (16%)
		leucine-rich repeat	400..426	CDD:275381	5/25 (20%)
		leucine-rich repeat	427..535	CDD:275381	11/107 (10%)
		AMN1	515..>642	CDD:187754	27/122 (22%)
		leucine-rich repeat	536..560	CDD:275381	7/24 (29%)
		leucine-rich repeat	561..586	CDD:275381	8/39 (21%)
		leucine-rich repeat	587..612	CDD:275381	4/24 (17%)
		leucine-rich repeat	613..638	CDD:275381	3/8 (38%)
		leucine-rich repeat	639..663	CDD:275381
		F-box-like	12..>44	CDD:289689
		leucine-rich repeat	129..166	CDD:275381
		leucine-rich repeat	167..192	CDD:275381
		leucine-rich repeat	193..244	CDD:275381
		C2	<231..274	CDD:301316	4/16 (25%)
		leucine-rich repeat	246..269	CDD:275381	1/3 (33%)
FBXL12	XP_016882401.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900