DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8272 and Fbxl17

DIOPT Version :9

Sequence 1:	NP_001260812.1	Gene:	CG8272 / 35875	FlyBaseID:	FBgn0033337	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_056609.1	Gene:	Fbxl17 / 50758	MGIID:	1354704	Length:	701	Species:	Mus musculus

Alignment Length:	351	Identity:	81/351 - (23%)
Similarity:	145/351 - (41%)	Gaps:	86/351 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 SLSL-KRCLPLFMSGSFLDSYNNSCPDLNDLASNLAGIKELTLCENQYLTDAILMRLTSFMPSLE 194
            :||| :|||    |.|.:      |....||..:....|:|.|...|.:||.:|.::.|...::.
Mouse   335 NLSLNERCL----SASLV------CKYWRDLCLDFQFWKQLDLSSRQQVTDELLEKIASRSQNII 389

  Fly   195 AINMSGCH---------IAFH--NAIHRRFYPATSSSD----------------HVLPSESVLTF 232
            .||:|.|.         :||.  ..:....|.....||                || .::..||.
Mouse   390 EINISDCRSLSDSGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHV-GNQDKLTD 453

  Fly   233 KFILTILNLQRRTLRVLNFS--HTLIGQALLALCDLNLQLQRLYLAGCRQLNCTTILNFLATQPQ 295
            :. |..|..:.|.|:.::|.  :.:..:.::.:....|:|||:|
Mouse   454 EG-LKQLGSRCRELKDIHFGQCYKISDEGMIVIAKSCLKLQRIY--------------------- 496

  Fly   296 LCALDLSATMCVNDENLAALVQTNPQLEHLKVNGCLSITNAGAIHLAKLKCLKSLDISNCDNLTS 360
                 :.....|.|:::.|..:..|:|:::...|| |:|:.|.|||.||:.|.|||:.:...|.:
Mouse   497 -----MQENKLVTDQSVKAFAEHCPELQYVGFMGC-SVTSKGVIHLTKLRNLSSLDLRHITELDN 555

  Fly   361 SGIIEGIASEENPVIQEL-NVSYLQIC------EECIKAIASNLRCLRSLHLNHCVNGATDEAIQ 418
            ..::|        :::.. |:|.|.:|      :.|::.||...:.|:.|:|..|  ..||.|:.
Mouse   556 ETVME--------IVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSC--KITDYALI 610

  Fly   419 SVIGQLRWLRELSLEHCSGLTDAALT 444
            ::......:..:.:..|..:||...|
Mouse   611 AIGRYSVTIETVDVGWCKEITDQGAT 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8272	NP_001260812.1	AMN1	269..440	CDD:187754	40/177 (23%)
		leucine-rich repeat	270..295	CDD:275381	4/24 (17%)
		leucine-rich repeat	296..319	CDD:275381	3/22 (14%)
		leucine-rich repeat	322..346	CDD:275381	11/23 (48%)
		leucine-rich repeat	347..399	CDD:275381	13/58 (22%)
		leucine-rich repeat	400..426	CDD:275381	7/25 (28%)
		leucine-rich repeat	427..535	CDD:275381	4/18 (22%)
		AMN1	515..>642	CDD:187754
		leucine-rich repeat	536..560	CDD:275381
		leucine-rich repeat	561..586	CDD:275381
		leucine-rich repeat	587..612	CDD:275381
		leucine-rich repeat	613..638	CDD:275381
		leucine-rich repeat	639..663	CDD:275381
		F-box-like	12..>44	CDD:289689
		leucine-rich repeat	129..166	CDD:275381	11/35 (31%)
		leucine-rich repeat	167..192	CDD:275381	8/24 (33%)
		leucine-rich repeat	193..244	CDD:275381	15/77 (19%)
		C2	<231..274	CDD:301316	10/44 (23%)
		leucine-rich repeat	246..269	CDD:275381	2/24 (8%)
Fbxl17	NP_056609.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	73..93
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	227..250
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	279..321
		F-box-like	321..368	CDD:289689	13/42 (31%)
		leucine-rich repeat	362..387	CDD:275381	8/24 (33%)
		leucine-rich repeat	388..413	CDD:275381	6/24 (25%)
		AMN1	411..573	CDD:187754	41/198 (21%)
		leucine-rich repeat	414..439	CDD:275381	3/24 (13%)
		leucine-rich repeat	440..465	CDD:275381	6/26 (23%)
		leucine-rich repeat	466..491	CDD:275381	2/24 (8%)
		leucine-rich repeat	492..517	CDD:275381	7/50 (14%)
		leucine-rich repeat	545..567	CDD:275381	4/29 (14%)
		leucine-rich repeat	568..593	CDD:275381	6/24 (25%)
		leucine-rich repeat	594..618	CDD:275381	7/25 (28%)
		leucine-rich repeat	619..644	CDD:275381	4/18 (22%)
		leucine-rich repeat	645..670	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843109
Domainoid	1	1.000	51	1.000	Domainoid score	I11563
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740