DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8272 and fbxl4

DIOPT Version :9

Sequence 1:	NP_001260812.1	Gene:	CG8272 / 35875	FlyBaseID:	FBgn0033337	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_001007316.1	Gene:	fbxl4 / 492349	ZFINID:	ZDB-GENE-041114-187	Length:	607	Species:	Danio rerio

Alignment Length:	564	Identity:	111/564 - (19%)
Similarity:	184/564 - (32%)	Gaps:	198/564 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 PHLHSLSL-KRCLPLFMSGSFLDSYNN------------------SCP--DLNDLASNLAGIKEL 170
            |::..:|. ...|.|.::.|.||.|..                  ..|  |:|||:.:...|.|.
Zfish   182 PNIKQISFTTNLLRLEVNSSLLDYYTELDAVILRGVRERPILALYKIPVIDINDLSDSEEEISEA 246

  Fly   171 -TLC-----EN-QYLTDAILMRL--------TSFMPSLEAINMSGCHIAFHNAIHRRFYPATSSS 220
             .||     || |.|.:....||        .|.:|..:...::.....||.
Zfish   247 GGLCCRSTAENRQSLANGYFDRLPYELIQLIVSHLPVPDLCRLAQSCKLFHK------------- 298

  Fly   221 DHVL-PSESVLTFKFILTILNLQRRTLRVLNFSHTLIGQALLALCDLNLQ---LQRLYLAGCRQL 281
             |.. |.:.:.        |:||....|:.:.|          ||.|..:   ||||.|:.....
Zfish   299 -HCCDPLQYIQ--------LSLQPYWARLTDAS----------LCHLQSRCTLLQRLNLSWTGNR 344

  Fly   282 NCTTILNFL----ATQPQLCALDLSATMCVNDENLAALVQTNPQLEHLKVNGCLSITNAGAIHLA 342
            ...|...|.    |....|..|::|....:.:..|..:.||.|.|:.|.:..|..:......|:|
Zfish   345 GAVTPAGFCSFMKACGASLVCLEVSCCHFLTEACLEVITQTCPCLQELNLASCDRLQPQAFNHIA 409

  Fly   343 KLKCLKSLDISNCDNLTSSGIIEGIASEENPVIQELNVSYLQICEECIKAIASNLRCLRSLHLNH 407
            ||..|:.|            ::.....|::.::     |.|..|.|           ||.|:|..
Zfish   410 KLTHLRRL------------VLYRTKVEQSAIL-----SILTFCPE-----------LRHLNLGS 446

  Fly   408 CVNGATDEAIQSVI-GQLRWLRELSLEHCSGLTDAALTGINISKLEMSRKQSGSQVSSMDNFYPP 471
            ||.....:.:.|:: .:.|.||.|.|..|..|::..|.
Zfish   447 CVMIEDYDVVVSMLSARCRSLRSLDLWRCRNLSERGLA--------------------------- 484

  Fly   472 YSNTLAERDSLAGSLQSIKISLRSKAEDEIVRDARRKQAMLAAYEMNLIREDDFEGHNIQQLRGL 536
                                        |:|...|.                            |
Zfish   485 ----------------------------ELVSGCRL----------------------------L 493

  Fly   537 RSLNLRGCNKISDVSLKYGLKHI-----ELRRLMLSNCQQISLLGMEAMASSCPSIEELDLSDCY 596
            ..|:|..|:.:...|..:  :|:     .||:|.|:..:.:....:|.:|::|.:::.||:....
Zfish   494 EELDLGWCSTLQSSSACF--QHLARSLPRLRKLFLTANRTVCDADLEELAANCSALQHLDILGTR 556

  Fly   597 NITDKTIQVVTSKLPRLKALHISGCSQLTE---HTLDAIITNCS 637
            .::..:::.:....||||.|.:|.|||:..   ..|:.:..|.|
Zfish   557 MVSSASLRKLLQCCPRLKLLDVSFCSQIDSRFVQELNGLFPNVS 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8272	NP_001260812.1	AMN1	269..440	CDD:187754	43/178 (24%)
		leucine-rich repeat	270..295	CDD:275381	8/28 (29%)
		leucine-rich repeat	296..319	CDD:275381	5/22 (23%)
		leucine-rich repeat	322..346	CDD:275381	7/23 (30%)
		leucine-rich repeat	347..399	CDD:275381	7/51 (14%)
		leucine-rich repeat	400..426	CDD:275381	7/26 (27%)
		leucine-rich repeat	427..535	CDD:275381	10/107 (9%)
		AMN1	515..>642	CDD:187754	27/131 (21%)
		leucine-rich repeat	536..560	CDD:275381	6/28 (21%)
		leucine-rich repeat	561..586	CDD:275381	7/24 (29%)
		leucine-rich repeat	587..612	CDD:275381	2/24 (8%)
		leucine-rich repeat	613..638	CDD:275381	10/28 (36%)
		leucine-rich repeat	639..663	CDD:275381
		F-box-like	12..>44	CDD:289689
		leucine-rich repeat	129..166	CDD:275381	12/57 (21%)
		leucine-rich repeat	167..192	CDD:275381	11/39 (28%)
		leucine-rich repeat	193..244	CDD:275381	7/51 (14%)
		C2	<231..274	CDD:301316	11/45 (24%)
		leucine-rich repeat	246..269	CDD:275381	5/22 (23%)
fbxl4	NP_001007316.1	F-box-like	266..312	CDD:289689	9/67 (13%)
		leucine-rich repeat	281..303	CDD:275381	4/35 (11%)
		leucine-rich repeat	304..326	CDD:275381	7/39 (18%)
		AMN1	<317..436	CDD:187754	32/145 (22%)
		leucine-rich repeat	333..362	CDD:275381	8/28 (29%)
		leucine-rich repeat	363..388	CDD:275381	6/24 (25%)
		leucine-rich repeat	389..413	CDD:275381	7/23 (30%)
		AMN1	414..591	CDD:187754	49/289 (17%)
		leucine-rich repeat	414..438	CDD:275381	6/40 (15%)
		leucine-rich repeat	439..466	CDD:275381	7/26 (27%)
		leucine-rich repeat	467..492	CDD:275381	9/79 (11%)
		leucine-rich repeat	493..520	CDD:275381	6/28 (21%)
		leucine-rich repeat	521..545	CDD:275381	6/23 (26%)
		leucine-rich repeat	547..572	CDD:275381	2/24 (8%)
		leucine-rich repeat	573..598	CDD:275381	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900