DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8272 and Skp2

DIOPT Version :9

Sequence 1:NP_001260812.1 Gene:CG8272 / 35875 FlyBaseID:FBgn0033337 Length:710 Species:Drosophila melanogaster
Sequence 2:NP_730815.2 Gene:Skp2 / 40548 FlyBaseID:FBgn0037236 Length:559 Species:Drosophila melanogaster


Alignment Length:577 Identity:114/577 - (19%)
Similarity:190/577 - (32%) Gaps:197/577 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 SDQLSPGVDLMRCERRFQHFLFEDVTLGQVKELMRFMGRTAQSLALDNVDLNDKQFYGMLGVLPH 128
            |::.:|...:.|...:.||  .:.::||...::      |..|.|:::.....:|....|.:|..
  Fly    91 SNETTPCASVSRMAHQLQH--TQRLSLGSTGDI------TLDSPAVEDSLSMSRQSAEKLQILAQ 147

  Fly   129 LHSLSLKRCLPLFMSGSFLDSYNNSCPDLNDLASNLAGIKELTLCENQYLTDAILMRLTSFMPSL 193
            ....||         ||  :...||......|.:.||.:    .|.||....|.|    :|.||.
  Fly   148 AKRSSL---------GS--EGSGNSNSPSKRLRNPLAAV----TCNNQIDGTASL----NFQPST 193

  Fly   194 EAINMSGCHIAFHNAIHRRFYPATSS-SDHVLPSESVLTFKFILTILNLQRRTLRVLNFSHTLIG 257
            ..:..          :.:...|:|:: :..::.::|...|:......::...    :|:...|..
  Fly   194 SRLAQ----------VRQAKKPSTTNITTRIVAADSFFVFRTPAMSAHINSG----INYFERLSD 244

  Fly   258 QALLALCDLNLQLQRLYLAG-CRQLNCTTILNFLATQPQLCALDLSATMCVNDENL-----AALV 316
            :.||.:.....:...|.:|. ||:.|                      .|..||.|     ..|.
  Fly   245 EILLDIFKWLPKKTLLRMATVCRRFN----------------------RCSRDETLWTRLDLGLR 287

  Fly   317 QTNP-QLEHLKVNGCLSITNAGAIHLAKLKCLKSLDISNCDNLTSSGIIEGIASEENPV----IQ 376
            ...| .||.:...|.|.|                       .|..:.|.|...:....|    :|
  Fly   288 TIRPGALEQIVRRGVLVI-----------------------RLAQTSIQEPAFAPYTEVFRTRLQ 329

  Fly   377 ELNVSYLQICEECIKAIASNLRCLRSLHLNH-------CVNGATDEAIQSVIGQLRWLRELSLEH 434
            .|::|...|....:..:.|:.|.|:.:.|.:       |...|.:||:::|          :|..
  Fly   330 YLDLSMASITRSSLLTLLSHCRQLKKISLENIELDDDICAEIAKNEALEAV----------NLTM 384

  Fly   435 CSGLTDAALTGINISKLEMSRKQSGSQVSSMDNFYPPYSNTLAERDSLAGSLQSIKISLRSKAED 499
            .||||.      |..:|.|                          :||. ||.|:.||....:.|
  Fly   385 ASGLTS------NSVRLMM--------------------------ESLT-SLSSLNISWTDLSAD 416

  Fly   500 EIVRDARRKQAMLAAYEMNLIREDDFEGHNIQQLRGLRSLNLRGCNKISDVSLKYGLKHIELRRL 564
            .:.       |::.....||||                 ||:.||                 ||:
  Fly   417 AVT-------ALVTHISPNLIR-----------------LNIAGC-----------------RRV 440

  Fly   565 MLSNCQQISLLGMEAMASSCPSIEELDLSDCYNITDKTIQVVTSKLPRLKALHISGC 621
            :..:       .:..:...||.:.|||||||.::|...|..: .|...|:.|.:|.|
  Fly   441 LFDS-------HVATLQKRCPQLLELDLSDCNSLTPTVITAI-MKFKMLEYLSVSRC 489

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8272NP_001260812.1 AMN1 269..440 CDD:187754 37/188 (20%)
leucine-rich repeat 270..295 CDD:275381 5/25 (20%)
leucine-rich repeat 296..319 CDD:275381 5/27 (19%)
leucine-rich repeat 322..346 CDD:275381 5/23 (22%)
leucine-rich repeat 347..399 CDD:275381 9/55 (16%)
leucine-rich repeat 400..426 CDD:275381 7/32 (22%)
leucine-rich repeat 427..535 CDD:275381 21/107 (20%)
AMN1 515..>642 CDD:187754 26/107 (24%)
leucine-rich repeat 536..560 CDD:275381 4/23 (17%)
leucine-rich repeat 561..586 CDD:275381 3/24 (13%)
leucine-rich repeat 587..612 CDD:275381 10/24 (42%)
leucine-rich repeat 613..638 CDD:275381 4/9 (44%)
leucine-rich repeat 639..663 CDD:275381
F-box-like 12..>44 CDD:289689
leucine-rich repeat 129..166 CDD:275381 8/36 (22%)
leucine-rich repeat 167..192 CDD:275381 6/24 (25%)
leucine-rich repeat 193..244 CDD:275381 4/51 (8%)
C2 <231..274 CDD:301316 5/42 (12%)
leucine-rich repeat 246..269 CDD:275381 4/22 (18%)
Skp2NP_730815.2 F-box-like 239..284 CDD:289689 12/66 (18%)
leucine-rich repeat 302..327 CDD:275381 6/47 (13%)
AMN1 309..480 CDD:187754 55/262 (21%)
leucine-rich repeat 328..352 CDD:275381 5/23 (22%)
leucine-rich repeat 353..376 CDD:275381 4/22 (18%)
leucine-rich repeat 377..402 CDD:275381 11/67 (16%)
leucine-rich repeat 403..428 CDD:275381 6/31 (19%)
leucine-rich repeat 429..455 CDD:275381 10/66 (15%)
leucine-rich repeat 456..480 CDD:275381 10/24 (42%)
leucine-rich repeat 481..500 CDD:275381 4/9 (44%)
leucine-rich repeat 506..529 CDD:275381
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45457980
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

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