DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8272 and CG32085

DIOPT Version :9

Sequence 1:	NP_001260812.1	Gene:	CG8272 / 35875	FlyBaseID:	FBgn0033337	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_729732.1	Gene:	CG32085 / 39311	FlyBaseID:	FBgn0052085	Length:	666	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	114/563 - (20%)
Similarity:	188/563 - (33%)	Gaps:	227/563 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 PHLH----SLSLKRCLPLFMSGSFLDSYNNSCPDLNDLASNLAGIKELTLCEN------QYLTD- 180
            ||||    |:.:....||.|      .:....|.::       .|::|.|.:.      ||.:.
  Fly   249 PHLHHPYGSMGINAASPLIM------QHQLHPPPIH-------SIEQLMLDDRFLSRFFQYFSPY 300

  Fly   181 --AILMRL---------------TSFMPSL---EAINMSGCHIA-FHNAIHRRFYPA---TSSSD 221
              .||.::               :..:|:|   |...|.||... .:|::.||.:.|   ..:||
  Fly   301 ERRILAQVCIKWRDTLYRSPRYWSGLLPTLQCRELRQMPGCDRGKLYNSLIRRGFHALGLVGASD 365

  Fly   222 HVLPSESVL--TFKFILTILNLQRRTLRVLNFSHTLIGQALLALCDLNLQLQRLYLAGCRQLN-- 282
                 |..|  ...|.|...::...:||..:.|    .:.|..|.|....|..|.||||.::.
  Fly   366 -----EDALDVVHSFPLASKHVHSLSLRCSSIS----DRGLETLLDHLQSLFELELAGCNEVTEA 421

  Fly   283 ----CTTILNFLATQPQLCALDLSATMCVNDENLAALVQTNPQL--------------------- 322
                |.|        |::.:|.|:..:.:.||.:.|:.|..|.|
  Fly   422 GLWACLT--------PRIVSLSLADCINIADEAVGAVAQLLPSLYEFSLQAYHVTDAALGYFSPK 478

  Fly   323 -EH----LKVNGCLSITNAGAIHLA-KLKCLKSLDISNCDNLTSSGIIEGIASEENPVIQELNVS 381
             .|    |::..|..:||.|.:::. .|..|..|.:|.|..||..|
  Fly   479 QSHSLSILRLQSCWELTNHGIVNIVHSLPHLTVLSLSGCSKLTDDG------------------- 524

  Fly   382 YLQICEECIKAIASNLRCLRSLHLNHCVNGATDEAIQSVIGQLRWLRELSLEHCSGLTDAALTGI 446
                    ::.||.||:.||:|.|:.|.. .||.:::.:...|..|.||:|:.|..:||..:
  Fly   525 --------VELIAENLQKLRALDLSWCPR-ITDASLEYIACDLNQLEELTLDRCVHITDIGV--- 577

  Fly   447 NISKLEMSRKQSGSQVSSMDNFYPPYSNTLAERDSLAGSLQSIKISLRSKAEDEIVRDARRKQAM 511

  Fly   578 ----------------------------------------------------------------- 577

  Fly   512 LAAYEMNLIREDDFEGHNIQQLRGLRSLNLRGCNKISDVSLKYGLKHIELRRLMLSNCQQISLLG 576
                           |: |..:..|.:|.||.|:::.|    :||:|:    ..:.|.|.:||.|
  Fly   578 ---------------GY-ISTMLSLTALFLRWCSQVRD----FGLQHL----CSMRNLQVLSLAG 618

  Fly   577 MEAMASSCPS-------IEELDLSDCYNITDKTIQVVTSKLPR 612
            ...:.||..|       ::||:|::|...:.:....:...|||
  Fly   619 CPLLTSSGLSSLIQLRHLQELELTNCPGASHELFDYLKEHLPR 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8272	NP_001260812.1	AMN1	269..440	CDD:187754	48/203 (24%)
		leucine-rich repeat	270..295	CDD:275381	8/30 (27%)
		leucine-rich repeat	296..319	CDD:275381	6/22 (27%)
		leucine-rich repeat	322..346	CDD:275381	8/50 (16%)
		leucine-rich repeat	347..399	CDD:275381	11/51 (22%)
		leucine-rich repeat	400..426	CDD:275381	8/25 (32%)
		leucine-rich repeat	427..535	CDD:275381	9/107 (8%)
		AMN1	515..>642	CDD:187754	26/105 (25%)
		leucine-rich repeat	536..560	CDD:275381	9/23 (39%)
		leucine-rich repeat	561..586	CDD:275381	7/24 (29%)
		leucine-rich repeat	587..612	CDD:275381	5/24 (21%)
		leucine-rich repeat	613..638	CDD:275381	114/563 (20%)
		leucine-rich repeat	639..663	CDD:275381
		F-box-like	12..>44	CDD:289689
		leucine-rich repeat	129..166	CDD:275381	7/40 (18%)
		leucine-rich repeat	167..192	CDD:275381	7/48 (15%)
		leucine-rich repeat	193..244	CDD:275381	15/59 (25%)
		C2	<231..274	CDD:301316	9/42 (21%)
		leucine-rich repeat	246..269	CDD:275381	6/22 (27%)
CG32085	NP_729732.1	leucine-rich repeat	382..406	CDD:275381	6/27 (22%)
		AMN1	383..600	CDD:187754	64/344 (19%)
		leucine-rich repeat	431..456	CDD:275381	6/24 (25%)
		leucine-rich repeat	457..482	CDD:275381	1/24 (4%)
		leucine-rich repeat	483..508	CDD:275381	6/24 (25%)
		leucine-rich repeat	509..534	CDD:275381	11/51 (22%)
		leucine-rich repeat	535..560	CDD:275381	8/25 (32%)
		leucine-rich repeat	561..585	CDD:275381	9/107 (8%)
		leucine-rich repeat	586..610	CDD:275381	9/31 (29%)
		leucine-rich repeat	636..661	CDD:275381	5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457963
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740