DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8272 and Fbxl6

DIOPT Version :9

Sequence 1:	NP_001260812.1	Gene:	CG8272 / 35875	FlyBaseID:	FBgn0033337	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_001005563.1	Gene:	Fbxl6 / 362941	RGDID:	1359687	Length:	535	Species:	Rattus norvegicus

Alignment Length:	515	Identity:	110/515 - (21%)
Similarity:	164/515 - (31%)	Gaps:	194/515 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GLEYGLHRYDDLPLEIVLKIFSYLGYSD-----LQAAGSTCQRWHAALDQAEFNQRTRVCFSKVV 62
            ||:.|..  |.:|||:::.||..|..:.     |..|...|:.||.|.....
  Rat    98 GLDSGWG--DRIPLEVLVHIFGLLVAAHGPMPFLGRAARVCRHWHEATSHPS------------- 147

  Fly    63 LSDQLSPGVDLMRCERRFQHFLFEDVTLGQVKELMRFMGRTAQSLALDNVDLNDKQFYGMLGVLP 127
                                 |:..|||...     .:||.|:.      :|..::
  Rat   148 ---------------------LWHTVTLSPA-----LVGRAAKG------NLKGEK--------- 171

  Fly   128 HLHSLSLKRCLPLFMSGSFLDSYNNSCPDLNDLASNLAGIKELTLCENQYLTDAILMRLTSFMPS 192
                 .|..||...:...|                  :.::.|||...:....::|..::.|.|.
  Rat   172 -----KLLACLEWLIPNRF------------------SQLQRLTLIHWKSQVHSVLELVSKFCPR 213

  Fly   193 LEAINMSGCH-------IAFHNA---IHRRFYPATSSSDHVLPSESVLTFKFILTILNLQRRTLR 247
            |..:.:|.||       :....|   :|       |...|....||.....|:....:..||...
  Rat   214 LTFLKLSDCHGVTAETLVMLAKACCQLH-------SLDLHHSMVESTAVVSFLEEAGSRMRRLWL 271

  Fly   248 VLNFSHTLIGQALLALCDLNLQ---------------------LQRLYLAGCRQLNCTTILNFL- 290
            ..:...|.|..|||..|...||                     |||    ||.||....:||.:
  Rat   272 TYSSQTTAILGALLGNCCSQLQVLEVSAGMSCNNTPLQLPVEALQR----GCPQLQVLRLLNLIW 332

  Fly   291 --------ATQ----PQLCALDLSATMC--VNDENLAALVQTNPQLEHLKVNGCLSITNAGAIHL 341
                    |.|    |.|..|.|:.:.|  |::|.|..|:..:|:|..|.:.||..||..|..||
  Rat   333 LPKPCGRGAPQGPGFPSLEELCLAGSTCSFVSNEVLGRLLHCSPKLRLLDLRGCARITPTGLCHL 397

  Fly   342 AKLKCLKSLDISNCDNLTS-----SGIIEG--IASEENPV--------IQELNVSYLQICEECIK 391
            .            |..|..     .|:.:|  :|.:.:|:        ::||:.|.....|:.::
  Rat   398 P------------CQELEQLYLGLYGMSDGLALAKDGSPLLTQKWYHTLRELDFSGQGFSEKDLE 450

  Fly   392 ---------------AIAS-NLRCLRSLHLNHCVNGATDEAIQSVIGQLRWLRELSLEHC 435
                           |:.| |||..|          .|...:.|||.....|..|:||.|
  Rat   451 QALAVFSGTTEGLPPALCSLNLRGTR----------VTPSTVSSVISSCPGLLYLNLESC 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8272	NP_001260812.1	AMN1	269..440	CDD:187754	56/234 (24%)
		leucine-rich repeat	270..295	CDD:275381	11/37 (30%)
		leucine-rich repeat	296..319	CDD:275381	8/24 (33%)
		leucine-rich repeat	322..346	CDD:275381	9/23 (39%)
		leucine-rich repeat	347..399	CDD:275381	14/82 (17%)
		leucine-rich repeat	400..426	CDD:275381	5/25 (20%)
		leucine-rich repeat	427..535	CDD:275381	5/9 (56%)
		AMN1	515..>642	CDD:187754
		leucine-rich repeat	536..560	CDD:275381
		leucine-rich repeat	561..586	CDD:275381
		leucine-rich repeat	587..612	CDD:275381
		leucine-rich repeat	613..638	CDD:275381
		leucine-rich repeat	639..663	CDD:275381
		F-box-like	12..>44	CDD:289689	12/36 (33%)
		leucine-rich repeat	129..166	CDD:275381	4/36 (11%)
		leucine-rich repeat	167..192	CDD:275381	5/24 (21%)
		leucine-rich repeat	193..244	CDD:275381	11/60 (18%)
		C2	<231..274	CDD:301316	14/63 (22%)
		leucine-rich repeat	246..269	CDD:275381	6/22 (27%)
Fbxl6	NP_001005563.1	F-box-like	105..155	CDD:289689	16/83 (19%)
		AMN1	171..390	CDD:187754	56/261 (21%)
		leucine-rich repeat	188..213	CDD:275381	5/24 (21%)
		leucine-rich repeat	214..239	CDD:275381	5/24 (21%)
		leucine-rich repeat	240..291	CDD:275381	14/57 (25%)
		leucine-rich repeat	292..321	CDD:275381	7/32 (22%)
		leucine-rich repeat	322..349	CDD:275381	5/26 (19%)
		AMN1	<349..500	CDD:187754	42/172 (24%)
		leucine-rich repeat	350..377	CDD:275381	8/26 (31%)
		leucine-rich repeat	378..401	CDD:275381	10/34 (29%)
		leucine-rich repeat	434..466	CDD:275381	4/31 (13%)
		leucine-rich repeat	467..491	CDD:275381	9/33 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346576
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830