DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8272 and Kdm2a

DIOPT Version :9

Sequence 1:	NP_001260812.1	Gene:	CG8272 / 35875	FlyBaseID:	FBgn0033337	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	XP_038939767.1	Gene:	Kdm2a / 361700	RGDID:	1309419	Length:	1166	Species:	Rattus norvegicus

Alignment Length:	533	Identity:	109/533 - (20%)
Similarity:	183/533 - (34%)	Gaps:	200/533 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 RFYPATSSSDHVLPSESVLTFKFILTILNLQRRTLRVLNFSHTLI--------GQALLALCD--- 265
            |..|....|||...|... .||        :|:.||:.....|::        |:..|:..:
  Rat   743 RSSPGAGPSDHHSASRDE-RFK--------RRQLLRLQATERTMVREKENNPSGKKELSEVEKAK 798

  Fly   266 -----LNLQLQRLYLAGCRQLNCTTILNFLATQPQLCALDLSATMCVNDENLAALVQTNPQ--LE 323
                 |.:.|||    ..::|:.|:|:      |:|.|:..|          :|.::.||:  ::
  Rat   799 IRGSYLTVTLQR----PTKELHGTSIV------PKLQAITAS----------SANLRPNPRVLMQ 843

  Fly   324 HLKVNGCLSITNAGAIHLAKLKCLKSLDISNCDNLTSSGIIEGIASEENPVIQE----------- 377
            |.....                             ...|..||:..||....:|
  Rat   844 HCPARN-----------------------------PQRGDEEGLGGEEEEEEEEEEDDSAEEGGA 879

  Fly   378 --LN-------------------------VSYLQICEECIKAIAS------NLRCLRSLHLNHCV 409
              ||                         :|..::| ||::...:      :.|....:.|:.|
  Rat   880 ARLNGRGSWAQDGDESWMQREVWMSVFRYLSRRELC-ECMRVCKTWYKWCCDKRLWTKIDLSRC- 942

  Fly   410 NGATDEAIQSVI----------------GQLRWLRELSLEHCSGLTDAALTGINISKLEMSRKQS 458
            .....:|:..:|                .||.||    :....||.|..|.|.           |
  Rat   943 KAIVPQALSGIIKRQPVSLDLSWTNISKKQLTWL----VNRLPGLKDLLLAGC-----------S 992

  Fly   459 GSQVSSMDNFYPPYSNTLAERDSLAGSLQSIKISLRSKAEDEIVRDARRKQAMLAAYEMNLIRED 523
            .|.||::.....|...||..|.::.             .:|..:||.             |....
  Rat   993 WSAVSALSTSSCPLLRTLDLRWAVG-------------IKDPQIRDL-------------LTPPT 1031

  Fly   524 DFEGH-NIQQLRGLRSLNLRGCNKISDVSLKYGLKHIE-LRRLMLSNC-----QQISLLGMEAMA 581
            |..|. |..:||.:....|.|.: |:|.:|:..::|:. |.||.||:|     |..:||  .|:.
  Rat  1032 DKPGQDNRSKLRNMTDFRLAGLD-ITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLL--TAVG 1093

  Fly   582 SSCP-SIEELDLSDCYNITDKTIQVVTSKLPRLKALHISGCSQLTEHTLDAIITNCSCLQTLSIY 645
            ||.. |:.||:::.|..:||:|: ....::..:..:.:.||.|:|....:..|::      |||
  Rat  1094 SSTRYSLTELNMAGCNKLTDQTL-FFLRRIANVTLIDLRGCKQITRKACEHFISD------LSI- 1150

  Fly   646 RCRSMYTDLEERL 658
              .|:|...:|:|
  Rat  1151 --NSLYCLSDEKL 1161

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8272	NP_001260812.1	AMN1	269..440	CDD:187754	37/232 (16%)
		leucine-rich repeat	270..295	CDD:275381	6/24 (25%)
		leucine-rich repeat	296..319	CDD:275381	4/22 (18%)
		leucine-rich repeat	322..346	CDD:275381	1/23 (4%)
		leucine-rich repeat	347..399	CDD:275381	12/95 (13%)
		leucine-rich repeat	400..426	CDD:275381	6/41 (15%)
		leucine-rich repeat	427..535	CDD:275381	22/108 (20%)
		AMN1	515..>642	CDD:187754	36/134 (27%)
		leucine-rich repeat	536..560	CDD:275381	6/23 (26%)
		leucine-rich repeat	561..586	CDD:275381	12/30 (40%)
		leucine-rich repeat	587..612	CDD:275381	6/24 (25%)
		leucine-rich repeat	613..638	CDD:275381	5/24 (21%)
		leucine-rich repeat	639..663	CDD:275381	7/20 (35%)
		F-box-like	12..>44	CDD:289689
		leucine-rich repeat	129..166	CDD:275381
		leucine-rich repeat	167..192	CDD:275381
		leucine-rich repeat	193..244	CDD:275381	8/31 (26%)
		C2	<231..274	CDD:301316	12/58 (21%)
		leucine-rich repeat	246..269	CDD:275381	6/38 (16%)
Kdm2a	XP_038939767.1	cupin_RmlC-like	204..304	CDD:424065
		JHD	309..>344	CDD:407680
		CTD_KDM2A	455..522	CDD:412025
		zf-CXXC	<581..614	CDD:366873
		PHD_KDM2A	624..680	CDD:277113
		F-box-like	900..938	CDD:403981	5/38 (13%)
		leucine-rich repeat	934..958	CDD:275381	4/24 (17%)
		AMN1	936..1142	CDD:187754	59/251 (24%)
		leucine-rich repeat	959..982	CDD:275381	4/26 (15%)
		leucine-rich repeat	983..1006	CDD:275381	8/33 (24%)
		leucine-rich repeat	1007..1044	CDD:275381	11/62 (18%)
		leucine-rich repeat	1045..1069	CDD:275381	6/24 (25%)
		leucine-rich repeat	1070..1099	CDD:275381	12/30 (40%)
		leucine-rich repeat	1100..1124	CDD:275381	6/24 (25%)
		leucine-rich repeat	1125..1144	CDD:275381	4/18 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900