DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8272 and Fbxl4

DIOPT Version :9

Sequence 1:	NP_001260812.1	Gene:	CG8272 / 35875	FlyBaseID:	FBgn0033337	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_572951.1	Gene:	Fbxl4 / 32378	FlyBaseID:	FBgn0030555	Length:	669	Species:	Drosophila melanogaster

Alignment Length:	487	Identity:	106/487 - (21%)
Similarity:	173/487 - (35%)	Gaps:	153/487 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 MRLTSFMPSLEAINMSGCHIAFHNAIHRRFYPATSSSDHVLPSESV--------LTFKFILTILN 240
            :|...|.|:......:..|...:|.:.:..      :|:.:..|:.        |.|:.:|.||:
  Fly   281 LRTLKFQPNCGEDGATKLHEFINNDLSQFL------ADNCVDGEAAAPQICLTDLPFEILLRILS 339

  Fly   241 -LQRRTL-RVLNFSHTLIGQALLALCDLNLQLQRLYLAGCRQLNCTTILNFLATQ-PQLCALDLS 302
             |..::| ||.:.|.|....:...|....:.|:..:.....:|.||     ||.: ..|..||||
  Fly   340 YLDLKSLFRVGHVSRTFYDISRHPLLYAEISLKPYWDVASSELLCT-----LARRATMLRKLDLS 399

  Fly   303 ATMCVNDENLAA------LVQTNPQLEHLKVNGCLSITNAGAIHLAKLKC--LKSLDISNCDNLT 359
              .|....|::.      |.|....|.||::|.| ...||..|....:.|  |..|.:.||
  Fly   400 --WCGGFGNVSPTEFKKFLTQRGDNLTHLRLNSC-KFLNASCIENVGIVCDNLIELSLRNC---- 457

  Fly   360 SSGIIEGIASEENPVIQELNVSYLQICEECIKAIASNLRCLRSLHLNHCVNGATDEAIQSVIGQL 424
                     :.|.|:   ||.|.|           :||:.|..|.|....  ...|.:.|::...
  Fly   458 ---------ATEPPL---LNFSCL-----------ANLKNLERLDLFQTY--FETELLLSMLEGN 497

  Fly   425 RWLRELSLEHCSGLTDAALTGINISKLEMSRKQSGSQVSSMDNFYPPYSNTLAERDSLAGSLQSI 489
            |.|:.|:|..|         |:::               :|||.
  Fly   498 RKLKHLNLAFC---------GVSV---------------NMDNV--------------------- 517

  Fly   490 KISLRSKAEDEIVRDARRKQAMLAAYEMNLIREDDFEGH--------NIQQLRGLRSLNLRGCNK 546
                               .|.||.|...||..|.::.|        ::.:|..|..|:|..|
  Fly   518 -------------------AAHLATYNTQLISLDLWKAHFLSSRGLQSLARLHQLEELDLGWC-- 561

  Fly   547 ISDVSLKYGLKHIELRRLMLSNCQQISLLGMEA-----------MASSCPSIEELDLSDCYNITD 600
            :.:.||..||..      :||||.::..|.:.|           :|:...::|:|||....|||.
  Fly   562 MREASLGDGLFQ------LLSNCPKLKKLFLSAVRGTTERDLMHIAALGKNLEQLDLMGILNITH 620

  Fly   601 KTIQVVTSKLPRLKALHISGCSQLTEHTLDAI 632
            :.:..:....|:|:.|.:|.|..:.:...|.:
  Fly   621 ERVYDILVNCPKLQLLDLSFCDNIMDRDFDLL 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8272	NP_001260812.1	AMN1	269..440	CDD:187754	46/179 (26%)
		leucine-rich repeat	270..295	CDD:275381	6/25 (24%)
		leucine-rich repeat	296..319	CDD:275381	9/28 (32%)
		leucine-rich repeat	322..346	CDD:275381	8/23 (35%)
		leucine-rich repeat	347..399	CDD:275381	12/51 (24%)
		leucine-rich repeat	400..426	CDD:275381	5/25 (20%)
		leucine-rich repeat	427..535	CDD:275381	17/115 (15%)
		AMN1	515..>642	CDD:187754	34/137 (25%)
		leucine-rich repeat	536..560	CDD:275381	8/23 (35%)
		leucine-rich repeat	561..586	CDD:275381	7/35 (20%)
		leucine-rich repeat	587..612	CDD:275381	7/24 (29%)
		leucine-rich repeat	613..638	CDD:275381	5/20 (25%)
		leucine-rich repeat	639..663	CDD:275381
		F-box-like	12..>44	CDD:289689
		leucine-rich repeat	129..166	CDD:275381
		leucine-rich repeat	167..192	CDD:275381	2/7 (29%)
		leucine-rich repeat	193..244	CDD:275381	10/59 (17%)
		C2	<231..274	CDD:301316	12/44 (27%)
		leucine-rich repeat	246..269	CDD:275381	6/23 (26%)
Fbxl4	NP_572951.1	F-box-like	326..372	CDD:289689	12/45 (27%)
		leucine-rich repeat	393..422	CDD:275381	9/30 (30%)
		leucine-rich repeat	423..442	CDD:275381	8/19 (42%)
		LRR_RI	437..>641	CDD:238064	63/304 (21%)
		leucine-rich repeat	449..474	CDD:275381	12/51 (24%)
		leucine-rich repeat	475..499	CDD:275381	5/25 (20%)
		leucine-rich repeat	500..527	CDD:275381	12/90 (13%)
		leucine-rich repeat	528..552	CDD:275381	5/23 (22%)
		AMN1	552..>660	CDD:187754	28/109 (26%)
		leucine-rich repeat	553..580	CDD:275381	12/34 (35%)
		leucine-rich repeat	581..606	CDD:275381	3/24 (13%)
		leucine-rich repeat	607..632	CDD:275381	7/24 (29%)
		leucine-rich repeat	633..652	CDD:275381	5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457984
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740