DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8272 and Fbxl21

DIOPT Version :9

Sequence 1:	NP_001260812.1	Gene:	CG8272 / 35875	FlyBaseID:	FBgn0033337	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	XP_038951543.1	Gene:	Fbxl21 / 306750	RGDID:	1305555	Length:	460	Species:	Rattus norvegicus

Alignment Length:	465	Identity:	100/465 - (21%)
Similarity:	155/465 - (33%)	Gaps:	145/465 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LEYGLHRYDDLPLEIVLKIFSYLGYSDLQAAGSTCQRWHAALDQAEFNQRTRVCFSKVVLSDQLS 68
            |::|     .||..::|:||.||...|...|.|.|:.|:......
  Rat    66 LDWG-----TLPHHVILRIFQYLPLVDRARASSVCRSWNEVFHIP-------------------- 105

  Fly    69 PGVDLMRCERRFQHFLFEDVTLGQVKELMRFMGRTAQSLALDNVDLNDKQFYGMLGVLPHLHSLS 133
               ||.   |:|:..|.:..|        .:...|...|....:..:          ..||..:|
  Rat   106 ---DLW---RKFEFELNQSAT--------SYFKSTHPDLIQQIIKKH----------AAHLQYVS 146

  Fly   134 LKRCLPLFMSGSFLDSYNNSCPDLNDLASNLAGIKELTLCENQYLTDAILMRLTSFMPSLEAINM 198
            .|           :||...|.    :.|.::  :.:|..|..|.| ..|.....|||      ||
  Rat   147 FK-----------VDSSTESA----EAACHI--LSQLVNCSIQTL-GLISTAKPSFM------NM 187

  Fly   199 SGCHIAFHNAIHRRFYPATSSSDHVLPSESVLTFKFILTILNLQRRTLRVLNFSHT--LIGQALL 261
            ...|  |.:|:...|..:.|.|...:....|......:.:.| ...|||:|..|..  :....:|
  Rat   188 PKSH--FVSALTVVFVNSKSLSSIKIEDTPVDDPSLKILVAN-NSDTLRLLKMSSCPHVSSDGIL 249

  Fly   262 ALCDLNLQLQRLYLAGCRQLNCTTILNFLATQPQLCALDLSATMCVNDENLAAL-VQTNPQLEHL 325
            .:.|        :..|.|:|    .||:               ..::||.|.|| .:|:..||||
  Rat   250 CVAD--------HCQGLREL----ALNY---------------YILSDELLLALSSETHVNLEHL 287

  Fly   326 KVNGCLSITNAGAIHLAKLKCLKSLDISNCDNLT--SSGI------------IEGIASEENPVIQ 376
            :::  :...|.|.|....:|      ..:.|.|.  |.|:            .:....||.|
  Rat   288 RID--VVSENPGQIKFHSIK------KPSWDALVKHSPGVNVVMYFFLYEEEFDTFFKEETP--- 341

  Fly   377 ELNVSYLQICEECIKAIAS--NLRCLRSLHLNHCVNGATDEAIQSVIGQLRWLRELSLEHCSGLT 439
               |::|.......:.|..  .|.|.|.:.|..|.||     :|.:..:|..:    .|||..||
  Rat   342 ---VTHLYFGRSVSRTILGRIGLNCPRLIELVVCANG-----LQPLDSELIRI----AEHCKNLT 394

  Fly   440 DAALTGINIS 449
            ...|:...:|
  Rat   395 ALGLSECEVS 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8272	NP_001260812.1	AMN1	269..440	CDD:187754	42/187 (22%)
		leucine-rich repeat	270..295	CDD:275381	5/24 (21%)
		leucine-rich repeat	296..319	CDD:275381	5/23 (22%)
		leucine-rich repeat	322..346	CDD:275381	7/23 (30%)
		leucine-rich repeat	347..399	CDD:275381	11/67 (16%)
		leucine-rich repeat	400..426	CDD:275381	7/25 (28%)
		leucine-rich repeat	427..535	CDD:275381	7/23 (30%)
		AMN1	515..>642	CDD:187754
		leucine-rich repeat	536..560	CDD:275381
		leucine-rich repeat	561..586	CDD:275381
		leucine-rich repeat	587..612	CDD:275381
		leucine-rich repeat	613..638	CDD:275381
		leucine-rich repeat	639..663	CDD:275381
		F-box-like	12..>44	CDD:289689	12/31 (39%)
		leucine-rich repeat	129..166	CDD:275381	7/36 (19%)
		leucine-rich repeat	167..192	CDD:275381	8/24 (33%)
		leucine-rich repeat	193..244	CDD:275381	10/50 (20%)
		C2	<231..274	CDD:301316	8/44 (18%)
		leucine-rich repeat	246..269	CDD:275381	6/24 (25%)
Fbxl21	XP_038951543.1	F-box-like	68..111	CDD:403981	16/73 (22%)
		leucine-rich repeat	206..231	CDD:275381	3/25 (12%)
		leucine-rich repeat	232..257	CDD:275381	6/32 (19%)
		leucine-rich repeat	258..283	CDD:275381	10/43 (23%)
		leucine-rich repeat	284..318	CDD:275381	11/41 (27%)
		leucine-rich repeat	329..365	CDD:275381	8/41 (20%)
		AMN1	<359..>424	CDD:187754	16/55 (29%)
		leucine-rich repeat	366..392	CDD:275381	9/34 (26%)
		leucine-rich repeat	393..418	CDD:275381	4/12 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346623
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830