DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8272 and Kdm2b

DIOPT Version :9

Sequence 1:	NP_001260812.1	Gene:	CG8272 / 35875	FlyBaseID:	FBgn0033337	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	XP_038945396.1	Gene:	Kdm2b / 304495	RGDID:	1310217	Length:	1350	Species:	Rattus norvegicus

Alignment Length:	379	Identity:	82/379 - (21%)
Similarity:	141/379 - (37%)	Gaps:	105/379 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   290 LATQPQLCALDLSATMCVNDENLAALVQTNPQLEHLKVNGCLSITNAGAIHLAKLKCLKSLDISN 354
            ::..|....||..|...::.|...|:..   .|.|..:..|:.:...........:....:|:::
  Rat  1062 ISPPPDSLPLDDGAAHVMHREVWMAVFS---YLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNH 1123

  Fly   355 CDNLTS---SGIIEGIASEENPVIQELNVSYLQICEECIKAIASNLRCLRSLHLNHCVNGATDEA 416
            |.::|.   ||||     ...||  .|::|:..|.::.:..:.:.|..||.|.|:.|...|....
  Rat  1124 CKSITPLMLSGII-----RRQPV--SLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSAL 1181

  Fly   417 IQSVIGQLRWLRELSLEHCSGLTDAALTGINISKLEMSRKQSGSQVSSMDNFYPPYSNTLAERDS 481
            ..|   ....||.|.::...||.||.:                     .|...||..|...:.|:
  Rat  1182 CSS---SCPLLRTLDVQWVEGLKDAQM---------------------RDLLSPPTDNRPGQMDN 1222

  Fly   482 LAGSLQSIKISLRSKAEDEIVRDARRKQAMLAAYEMNLIREDDFEGHNIQQLRGLRSLNLRGCNK 546
                        |||                                    ||.:..|.|.|.:
  Rat  1223 ------------RSK------------------------------------LRNIVELRLAGLD- 1238

  Fly   547 ISDVSLKYGLKHIE-LRRLMLSNC-----QQISLLGMEAMASSC-PSIEELDLSDCYNITDKTIQ 604
            |:||||:..::|:. |.:|.||.|     |.|:||  .|:.::. .|:.|::||||..:||:.:.
  Rat  1239 ITDVSLRLIIRHMPLLSKLHLSYCNHVTDQSINLL--TAVGTTTRDSLTEINLSDCNKVTDQCLS 1301

  Fly   605 VVTSKLPRLKALHISGCSQLTEHTLDAIITNCSCLQTLSIYRCRSMYTDLEERL 658
            .. .:...:..:.:..|.|:|:...:..|...|    :|:     .:..:||:|
  Rat  1302 FF-KRCGNICHIDLRYCKQVTKEGCEQFIAEMS----VSV-----QFGQVEEKL 1345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8272	NP_001260812.1	AMN1	269..440	CDD:187754	34/152 (22%)
		leucine-rich repeat	270..295	CDD:275381	0/4 (0%)
		leucine-rich repeat	296..319	CDD:275381	5/22 (23%)
		leucine-rich repeat	322..346	CDD:275381	3/23 (13%)
		leucine-rich repeat	347..399	CDD:275381	13/54 (24%)
		leucine-rich repeat	400..426	CDD:275381	7/25 (28%)
		leucine-rich repeat	427..535	CDD:275381	16/107 (15%)
		AMN1	515..>642	CDD:187754	34/133 (26%)
		leucine-rich repeat	536..560	CDD:275381	9/23 (39%)
		leucine-rich repeat	561..586	CDD:275381	10/30 (33%)
		leucine-rich repeat	587..612	CDD:275381	7/24 (29%)
		leucine-rich repeat	613..638	CDD:275381	4/24 (17%)
		leucine-rich repeat	639..663	CDD:275381	4/20 (20%)
		F-box-like	12..>44	CDD:289689
		leucine-rich repeat	129..166	CDD:275381
		leucine-rich repeat	167..192	CDD:275381
		leucine-rich repeat	193..244	CDD:275381
		C2	<231..274	CDD:301316
		leucine-rich repeat	246..269	CDD:275381
Kdm2b	XP_038945396.1	JmjC	151..226	CDD:214721
		cupin_RmlC-like	198..304	CDD:424065
		JHD	303..>338	CDD:407680
		CTD_KDM2B	476..584	CDD:412026
		zf-CXXC	<626..662	CDD:366873
		PHD_KDM2B	672..733	CDD:277114
		PTZ00449	<731..967	CDD:185628
		F-box-like	1082..1120	CDD:403981	5/40 (13%)
		leucine-rich repeat	1116..1140	CDD:275381	7/28 (25%)
		AMN1	1132..1321	CDD:187754	63/271 (23%)
		leucine-rich repeat	1141..1164	CDD:275381	5/24 (21%)
		leucine-rich repeat	1165..1188	CDD:275381	7/25 (28%)
		leucine-rich repeat	1189..1228	CDD:275381	16/107 (15%)
		leucine-rich repeat	1229..1253	CDD:275381	9/24 (38%)
		leucine-rich repeat	1254..1283	CDD:275381	10/30 (33%)
		leucine-rich repeat	1284..1308	CDD:275381	7/24 (29%)
		leucine-rich repeat	1309..1333	CDD:275381	4/23 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900