Protein Alignment CG8272 and FBXL22

DIOPT Version :10

• Sequence 1: NP_001260812.1
• Gene: CG8272 / 35875
• FlyBaseID: FBgn0033337
• Length: 710
• Species: Drosophila melanogaster
• Sequence 2: NP_976307.2
• Gene: FBXL22 / 283807
• HGNCID: 27537
• Length: 247
• Species: Homo sapiens
• Alignment Length: 129
• Identity: 32/129 - (24%)
• Similarity: 53/129 - (41%)
• Gaps: 25/129 - (19%)

  Fly   396 NLRCLRSLHLNHCVNGATDEAIQSVIGQLR--------WLRELSLEHCSGLT----DAALTGINI 448
            |..||  |||...::..:.:::.....||.        |    ||.|...||    |..|.|..:
Human    13 NRECL--LHLFSFLDKDSRKSLARTCSQLHDVFEDPALW----SLLHFRSLTELQKDNFLLGPAL 71

  Fly   449 SKLEMSRKQSGSQVSSMDNFY-PPYSNTLAER-DSLAGSLQSIKISLRSKAEDEIVRDARRKQA 510
            ..|.:....|..||.|::::. ..:..::..| :||.... .:::..|..|    ||..||::|
Human    72 RSLSICWHSSRVQVCSIEDWLKSAFQRSICSRHESLVNDF-LLRVCDRLSA----VRSPRRREA 130

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8272	NP_001260812.1	F-box_SF	11..58	CDD:459239
		leucine-rich repeat	129..166	CDD:275381
		leucine-rich repeat	167..192	CDD:275381
		leucine-rich repeat	193..244	CDD:275381
		C2	<231..274	CDD:472691
		leucine-rich repeat	246..269	CDD:275381
		AMN1	269..440	CDD:187754	14/55 (25%)
		leucine-rich repeat	270..295	CDD:275381
		leucine-rich repeat	296..319	CDD:275381
		leucine-rich repeat	322..346	CDD:275381
		leucine-rich repeat	347..399	CDD:275381	1/2 (50%)
		leucine-rich repeat	400..426	CDD:275381	6/33 (18%)
		leucine-rich repeat	427..535	CDD:275381	23/90 (26%)
		AMN1	515..>642	CDD:187754
		leucine-rich repeat	536..560	CDD:275381
		leucine-rich repeat	561..586	CDD:275381
		leucine-rich repeat	587..612	CDD:275381
		leucine-rich repeat	613..638	CDD:275381
		leucine-rich repeat	639..663	CDD:275381
FBXL22	NP_976307.2	F-box_FBXL22	9..51	CDD:438901	9/43 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	124..154		3/7 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	173..247