DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8272 and FBXL6

DIOPT Version :9

Sequence 1:	NP_001260812.1	Gene:	CG8272 / 35875	FlyBaseID:	FBgn0033337	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_036294.2	Gene:	FBXL6 / 26233	HGNCID:	13603	Length:	539	Species:	Homo sapiens

Alignment Length:	497	Identity:	112/497 - (22%)
Similarity:	170/497 - (34%)	Gaps:	174/497 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DDLPLEIVLKIFSYLGYSD-----LQAAGSTCQRWHAALDQAEFNQRTRVCFSKVVLSDQLSPGV 71
            |.:||||:::||..|..:|     |..|...|:||..|..|..
Human   113 DRIPLEILVQIFGLLVAADGPMPFLGRAARVCRRWQEAASQPA---------------------- 155

  Fly    72 DLMRCERRFQHFLFEDVTLGQVKELMRFMGRTAQSLALDNVDLNDKQFYGMLGVLPHLHSL-SLK 135
                        |:..|||..     ..:||.|:.                 ||......| ||:
Human   156 ------------LWHTVTLSS-----PLVGRPAKG-----------------GVKAEKKLLASLE 186

  Fly   136 RCLPLFMSGSFLDSYNNSCPDLNDLASNLAGIKELTLCENQYLTDAILMRLTSFMPSLEAINMSG 200
            ..:|                      :..:.::.|||...:.....:|..:....|.|..:.:||
Human   187 WLMP----------------------NRFSQLQRLTLIHWKSQVHPVLKLVGECCPRLTFLKLSG 229

  Fly   201 CHIAFHNA----------IHRRFYPATSSSDHVLPSESVLTFKFILTILNLQRRTLRVLNFSHT- 254
            ||....:|          :|     :......::.|.:|::|   |.....:.|.|.:...|.|
Human   230 CHGVTADALVMLAKACCQLH-----SLDLQHSMVESTAVVSF---LEEAGSRMRKLWLTYSSQTT 286

  Fly   255 -LIGQALLALCDLNLQ---------------------LQRLYLAGCRQLNCTTILNFLATQ---- 293
             ::| |||..|...||                     ||:    ||.||....:||.:...
Human   287 AILG-ALLGSCCPQLQVLEVSTGINRNSIPLQLPVEALQK----GCPQLQVLRLLNLMWLPKPPG 346

  Fly   294 ---------PQLCALDLSATMC--VNDENLAALVQTNPQLEHLKVNGCLSITNAGAIHLAKLKC- 346
                     |.|..|.|:::.|  |::|.|..|:..:|.|..|.:.||..||.||   |..|.|
Human   347 RGVAPGPGFPSLEELCLASSTCNFVSNEVLGRLLHGSPNLRLLDLRGCARITPAG---LQDLPCR 408

  Fly   347 -LKSLDI---SNCDNLTSSGIIEGIASEENP--------VIQELNVSYLQICEECI-KAIASNLR 398
             |:.|.:   ...|.||       :|.|.:|        .::||::|.....|:.: :|:|:.|.
Human   409 ELEQLHLGLYGTSDRLT-------LAKEGSPFLTQKWCHTLRELDLSGQGFSEKDLEQALAAFLS 466

  Fly   399 CLRSLH-----LNHCVNGATDEAIQSVIGQLRWLRELSLEHC 435
            .....|     ||......|...:.|||.....|..|:||.|
Human   467 TPGGSHPALCSLNLRGTRVTPSTVSSVISGCPGLLYLNLESC 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8272	NP_001260812.1	AMN1	269..440	CDD:187754	57/222 (26%)
		leucine-rich repeat	270..295	CDD:275381	8/37 (22%)
		leucine-rich repeat	296..319	CDD:275381	8/24 (33%)
		leucine-rich repeat	322..346	CDD:275381	10/23 (43%)
		leucine-rich repeat	347..399	CDD:275381	15/63 (24%)
		leucine-rich repeat	400..426	CDD:275381	7/30 (23%)
		leucine-rich repeat	427..535	CDD:275381	5/9 (56%)
		AMN1	515..>642	CDD:187754
		leucine-rich repeat	536..560	CDD:275381
		leucine-rich repeat	561..586	CDD:275381
		leucine-rich repeat	587..612	CDD:275381
		leucine-rich repeat	613..638	CDD:275381
		leucine-rich repeat	639..663	CDD:275381
		F-box-like	12..>44	CDD:289689	14/36 (39%)
		leucine-rich repeat	129..166	CDD:275381	4/37 (11%)
		leucine-rich repeat	167..192	CDD:275381	4/24 (17%)
		leucine-rich repeat	193..244	CDD:275381	11/60 (18%)
		C2	<231..274	CDD:301316	15/65 (23%)
		leucine-rich repeat	246..269	CDD:275381	8/24 (33%)
FBXL6	NP_036294.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..111
		F-box-like	113..163	CDD:289689	19/83 (23%)
		LRR 1	177..203		7/47 (15%)
		AMN1	185..398	CDD:187754	51/247 (21%)
		leucine-rich repeat	196..221	CDD:275381	4/24 (17%)
		LRR 2	204..229		3/24 (13%)
		leucine-rich repeat	222..247	CDD:275381	6/24 (25%)
		LRR 3	230..255		4/29 (14%)
		leucine-rich repeat	248..299	CDD:275381	14/59 (24%)
		LRR 4	281..307		9/26 (35%)
		leucine-rich repeat	300..329	CDD:275381	6/32 (19%)
		LRR 5	312..337		6/28 (21%)
		leucine-rich repeat	330..357	CDD:275381	3/26 (12%)
		LRR 6	341..365		4/23 (17%)
		AMN1	<357..508	CDD:187754	46/160 (29%)
		leucine-rich repeat	358..385	CDD:275381	8/26 (31%)
		LRR 7	368..393		8/24 (33%)
		leucine-rich repeat	386..409	CDD:275381	11/25 (44%)
		LRR 8	394..419		10/27 (37%)
		LRR 9	423..449		7/32 (22%)
		leucine-rich repeat	442..474	CDD:275381	8/31 (26%)
		LRR 10	453..481		7/27 (26%)
		leucine-rich repeat	475..499	CDD:275381	6/23 (26%)
		LRR 11	482..507		7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152985
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740