DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8272 and FBXL3

DIOPT Version :9

Sequence 1:	NP_001260812.1	Gene:	CG8272 / 35875	FlyBaseID:	FBgn0033337	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_036290.1	Gene:	FBXL3 / 26224	HGNCID:	13599	Length:	428	Species:	Homo sapiens

Alignment Length:	491	Identity:	95/491 - (19%)
Similarity:	158/491 - (32%)	Gaps:	157/491 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YDDLPLEIVLKIFSYLGYSDLQAAGSTCQRWHAALDQAEFNQRTRVCFSKVVLSDQLSPGVDLMR 75
            :.:|..:|:|::|.||...|...|...|:.|                       :|:....||.|
Human    36 WGNLLQDIILQVFKYLPLLDRAHASQVCRNW-----------------------NQVFHMPDLWR 77

  Fly    76 CERRFQHFLFEDVTLGQVKELMRFMGRTAQSLALDNVDLNDKQFYGMLGVLPHLHSLSLKRCLPL 140
            |   |:..|.:..|        .::..|...|....:..:..          ||..:|.|
Human    78 C---FEFELNQPAT--------SYLKATHPELIKQIIKRHSN----------HLQYVSFK----- 116

  Fly   141 FMSGSFLDSYNNSCPDLNDLASNLAGIKELTLCENQYLTDAILMRLTSFMPSLEAINMSGCHIAF 205
                  :||...|.....|:.|.|......||       ..|.....|||...::..:|...:.|
Human   117 ------VDSSKESAEAACDILSQLVNCSLKTL-------GLISTARPSFMDLPKSHFISALTVVF 168

  Fly   206 HNAIHRRFYPATSSSDHVLPSESVLTFKFILTILNLQRRTLRVLNFSHTLIGQALLALCDLNLQL 270
            .|                  |:|:.:.|...|.::.....:.|.|.|.|               |
Human   169 VN------------------SKSLSSLKIDDTPVDDPSLKVLVANNSDT---------------L 200

  Fly   271 QRLYLAGCRQLNCTTILNFLATQPQLCALDLSATMC------------VNDENLAAL-VQTNPQL 322
            :.|.::.|..::...|         ||..|    .|            ::||.|.|| .:.:.:|
Human   201 KLLKMSSCPHVSPAGI---------LCVAD----QCHGLRELALNYHLLSDELLLALSSEKHVRL 252

  Fly   323 EHLKVNGCLSITNAGAIHLAKLKCLKSLDISNCD---------NLTSSGIIEGIASEENPVIQ-E 377
            |||:::  :...|.|..|      ..::..|:.|         ||.....:  ...|.:|..: |
Human   253 EHLRID--VVSENPGQTH------FHTIQKSSWDAFIRHSPKVNLVMYFFL--YEEEFDPFFRYE 307

  Fly   378 LNVSYLQICEECIKAIAS--NLRCLRSLHLNHCVNG--ATDEAIQSVIGQLRWLRELSLEHCSGL 438
            :..::|.......|.:..  .:.|.|.:.|..|.||  ..||.:..:..:.:.|..:.|..|.
Human   308 IPATHLYFGRSVSKDVLGRVGMTCPRLVELVVCANGLRPLDEELIRIAERCKNLSAIGLGECE-- 370

  Fly   439 TDAALTGINISKLEMSRKQSG---SQVSSMDNFYPP 471
                   ::.|......|..|   ||:|.|:....|
Human   371 -------VSCSAFVEFVKMCGGRLSQLSIMEEVLIP 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8272	NP_001260812.1	AMN1	269..440	CDD:187754	40/197 (20%)
		leucine-rich repeat	270..295	CDD:275381	4/24 (17%)
		leucine-rich repeat	296..319	CDD:275381	9/35 (26%)
		leucine-rich repeat	322..346	CDD:275381	7/23 (30%)
		leucine-rich repeat	347..399	CDD:275381	9/63 (14%)
		leucine-rich repeat	400..426	CDD:275381	7/27 (26%)
		leucine-rich repeat	427..535	CDD:275381	11/48 (23%)
		AMN1	515..>642	CDD:187754
		leucine-rich repeat	536..560	CDD:275381
		leucine-rich repeat	561..586	CDD:275381
		leucine-rich repeat	587..612	CDD:275381
		leucine-rich repeat	613..638	CDD:275381
		leucine-rich repeat	639..663	CDD:275381
		F-box-like	12..>44	CDD:289689	10/31 (32%)
		leucine-rich repeat	129..166	CDD:275381	9/36 (25%)
		leucine-rich repeat	167..192	CDD:275381	6/24 (25%)
		leucine-rich repeat	193..244	CDD:275381	7/50 (14%)
		C2	<231..274	CDD:301316	7/42 (17%)
		leucine-rich repeat	246..269	CDD:275381	4/22 (18%)
FBXL3	NP_036290.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		F-box-like	36..77	CDD:403981	13/63 (21%)
		LRR 1	119..146		7/33 (21%)
		leucine-rich repeat	174..199	CDD:275381	5/24 (21%)
		LRR 2	181..207		7/40 (18%)
		leucine-rich repeat	200..225	CDD:275381	8/37 (22%)
		LRR 3	208..233		6/37 (16%)
		LRR 4	234..259		9/26 (35%)
		leucine-rich repeat	252..286	CDD:275381	9/41 (22%)
		leucine-rich repeat	287..333	CDD:275381	8/47 (17%)
		LRR 5	316..341		4/24 (17%)
		leucine-rich repeat	334..360	CDD:275381	6/25 (24%)
		LRR 6	343..368		5/24 (21%)
		leucine-rich repeat	361..383	CDD:275381	5/30 (17%)
		LRR 7	369..394		7/33 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153015
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.830