DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8272 and Fbxl19

DIOPT Version :9

Sequence 1:	NP_001260812.1	Gene:	CG8272 / 35875	FlyBaseID:	FBgn0033337	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	XP_036008913.1	Gene:	Fbxl19 / 233902	MGIID:	3039600	Length:	696	Species:	Mus musculus

Alignment Length:	226	Identity:	51/226 - (22%)
Similarity:	91/226 - (40%)	Gaps:	59/226 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   476 LAERDSLAGSLQSIKISLRSKAEDEIVRDARRKQAMLAAYEMNLIREDDFEGHNIQQLRGLRSLN 540
            |:.|.||...:.|..:..:.:|.|.......:||.|..                :.:|:||:.|.
Mouse   468 LSRRKSLTPPMLSGVVRRQPRALDLSWTGVSKKQLMWL----------------LNRLQGLQELV 516

  Fly   541 LRGCNKIS---------------DVSLKYGLKHIELRRLM----------------LSNCQQISL 574
            |.||:.:|               |:.....:|..:||.|:                |....::.|
Mouse   517 LSGCSWLSVSALGSAPLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRL 581

  Fly   575 LGMEAMASS-------CPSIEELDLSDCYNITDKTIQVVTSKLPRLKA----LHISGCSQLTEHT 628
            .|:|...:|       .|.:..||||.|.::.|.::.::|:....|:.    |:::||.:||:|.
Mouse   582 AGLELTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHC 646

  Fly   629 LDAIITNCSCLQTLSIYRCRSMYTDLEERLS 659
            | .:...|..|:.|.:..||.:..:...||:
Mouse   647 L-PLFRRCPRLRRLDLRSCRQLSPEACARLA 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8272	NP_001260812.1	AMN1	269..440	CDD:187754
		leucine-rich repeat	270..295	CDD:275381
		leucine-rich repeat	296..319	CDD:275381
		leucine-rich repeat	322..346	CDD:275381
		leucine-rich repeat	347..399	CDD:275381
		leucine-rich repeat	400..426	CDD:275381
		leucine-rich repeat	427..535	CDD:275381	11/58 (19%)
		AMN1	515..>642	CDD:187754	36/168 (21%)
		leucine-rich repeat	536..560	CDD:275381	8/38 (21%)
		leucine-rich repeat	561..586	CDD:275381	8/47 (17%)
		leucine-rich repeat	587..612	CDD:275381	7/24 (29%)
		leucine-rich repeat	613..638	CDD:275381	9/28 (32%)
		leucine-rich repeat	639..663	CDD:275381	6/21 (29%)
		F-box-like	12..>44	CDD:289689
		leucine-rich repeat	129..166	CDD:275381
		leucine-rich repeat	167..192	CDD:275381
		leucine-rich repeat	193..244	CDD:275381
		C2	<231..274	CDD:301316
		leucine-rich repeat	246..269	CDD:275381
Fbxl19	XP_036008913.1	zf-CXXC	<52..79	CDD:366873
		PHD_FXL19	89..150	CDD:277115
		F-box-like	426..467	CDD:403981
		AMN1	468..667	CDD:187754	49/215 (23%)
		leucine-rich repeat	488..511	CDD:275381	6/38 (16%)
		leucine-rich repeat	512..535	CDD:275381	6/22 (27%)
		leucine-rich repeat	573..600	CDD:275381	5/26 (19%)
		leucine-rich repeat	601..627	CDD:275381	7/25 (28%)
		leucine-rich repeat	631..655	CDD:275381	8/24 (33%)
		leucine-rich repeat	656..680	CDD:275381	6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843125
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740