DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8272 and FBXL7

DIOPT Version :9

Sequence 1:	NP_001260812.1	Gene:	CG8272 / 35875	FlyBaseID:	FBgn0033337	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_036436.1	Gene:	FBXL7 / 23194	HGNCID:	13604	Length:	491	Species:	Homo sapiens

Alignment Length:	486	Identity:	106/486 - (21%)
Similarity:	190/486 - (39%)	Gaps:	154/486 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 LTDAILMRLTSFMPSLEAINMSGCHIAFHNAIHRRFYPATSSSDHVLPSESVL--TFKFILTILN 240
            |.|..::::.||:|:.:.     |..|   .:.||:|.        |..:..|  |.:.....:|
Human   117 LPDHSMVQIFSFLPTNQL-----CRCA---RVCRRWYN--------LAWDPRLWRTIRLTGETIN 165

  Fly   241 LQRRTLRVLNFSHTLIGQALLALC----DLNLQLQRLYLAGCRQLNCTTILNFLATQPQLCALDL 301
            :. |.|:||.          ..||    ::.|.|:.:.::|||:|
Human   166 VD-RALKVLT----------RRLCQDTPNVCLMLETVTVSGCRRL-------------------- 199

  Fly   302 SATMCVNDENLAALVQTNPQLEHLKVNGCLSITNAGAIHLAKLKC--LKSLDISNCDNLTSSGII 364
                  .|..|..:.|..|:|..|:|:||.:|:|.....:..| |  |:.||:|.|..:|...:.
Human   200 ------TDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSL-CPNLEHLDVSGCSKVTCISLT 257

  Fly   365 EGIASEENPVI-QELNVSYLQI--C----EECIKAIASNLRCLRSLHLNHCVNGATDEAIQSVIG 422
            ...:.:.:|:. :::::.||.:  |    :|.:..||::...|..|:|..||. .|||.::.::.
Human   258 REASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVR-LTDEGLRYLVI 321

  Fly   423 QLRWLRELSLEHCSGLTDAALTGINISKLEMSRKQSGSQVSSMDNFYPPYSNTLAERDSLAGSLQ 487
            ....::|||:..|..::|..|.  .|:||| ||
Human   322 YCASIKELSVSDCRFVSDFGLR--EIAKLE-SR-------------------------------- 351

  Fly   488 SIKISLRSKAEDEIVRDARRKQAMLAAYEMNLIREDDFEGHNIQQLRGLRSLNLRGCNKISDVSL 552
                                                            ||.|::..|.:::||.:
Human   352 ------------------------------------------------LRYLSIAHCGRVTDVGI 368

  Fly   553 KYGLKHI-ELRRLMLSNCQQISLLGMEAMASSCPSIEELDLSDCYNITDKTIQVVTSKLPRLKAL 616
            :|..|:. :||.|....|:.|:..|:|.:|.:|..::.||:..|..::|..::.:......||.|
Human   369 RYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRL 433

  Fly   617 HISGCSQLTEHTLDAIITNCSCLQTLSIYRC 647
            .:..|..:|...|..:..||..||||::..|
Human   434 SLKSCESITGQGLQIVAANCFDLQTLNVQDC 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8272	NP_001260812.1	AMN1	269..440	CDD:187754	43/179 (24%)
		leucine-rich repeat	270..295	CDD:275381	5/24 (21%)
		leucine-rich repeat	296..319	CDD:275381	3/22 (14%)
		leucine-rich repeat	322..346	CDD:275381	8/23 (35%)
		leucine-rich repeat	347..399	CDD:275381	13/58 (22%)
		leucine-rich repeat	400..426	CDD:275381	8/25 (32%)
		leucine-rich repeat	427..535	CDD:275381	12/107 (11%)
		AMN1	515..>642	CDD:187754	31/127 (24%)
		leucine-rich repeat	536..560	CDD:275381	8/24 (33%)
		leucine-rich repeat	561..586	CDD:275381	9/24 (38%)
		leucine-rich repeat	587..612	CDD:275381	4/24 (17%)
		leucine-rich repeat	613..638	CDD:275381	8/24 (33%)
		leucine-rich repeat	639..663	CDD:275381	5/9 (56%)
		F-box-like	12..>44	CDD:289689
		leucine-rich repeat	129..166	CDD:275381
		leucine-rich repeat	167..192	CDD:275381	4/13 (31%)
		leucine-rich repeat	193..244	CDD:275381	9/52 (17%)
		C2	<231..274	CDD:301316	10/46 (22%)
		leucine-rich repeat	246..269	CDD:275381	5/26 (19%)
FBXL7	NP_036436.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..79
		F-box-like	114..157	CDD:372399	12/55 (22%)
		leucine-rich repeat	129..151	CDD:275381	7/37 (19%)
		leucine-rich repeat	154..187	CDD:275381	8/43 (19%)
		LRR 1	170..195		7/34 (21%)
		AMN1	<185..366	CDD:187754	56/291 (19%)
		leucine-rich repeat	188..213	CDD:275381	8/50 (16%)
		LRR 2	196..221		10/50 (20%)
		leucine-rich repeat	214..234	CDD:275381	7/19 (37%)
		LRR 3	222..247		8/25 (32%)
		leucine-rich repeat	240..273	CDD:275381	7/32 (22%)
		LRR 4	253..281		3/27 (11%)
		leucine-rich repeat	274..299	CDD:275381	6/24 (25%)
		LRR 5	282..307		7/24 (29%)
		AMN1	297..464	CDD:187754	53/250 (21%)
		leucine-rich repeat	300..325	CDD:275381	8/25 (32%)
		LRR 6	308..333		8/25 (32%)
		leucine-rich repeat	326..351	CDD:275381	10/27 (37%)
		LRR 7	334..359		12/107 (11%)
		leucine-rich repeat	352..377	CDD:275381	8/24 (33%)
		LRR 8	360..385		8/24 (33%)
		leucine-rich repeat	378..403	CDD:275381	9/24 (38%)
		LRR 9	386..411		8/24 (33%)
		leucine-rich repeat	404..429	CDD:275381	4/24 (17%)
		LRR 10	412..437		5/24 (21%)
		leucine-rich repeat	430..453	CDD:275381	6/22 (27%)
		LRR 11	438..463		9/24 (38%)
		leucine-rich repeat	456..480	CDD:275381	5/9 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153029
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740