DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8272 and Fbxl16

DIOPT Version :9

Sequence 1:	NP_001260812.1	Gene:	CG8272 / 35875	FlyBaseID:	FBgn0033337	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_001366323.1	Gene:	Fbxl16 / 214931	MGIID:	2448488	Length:	575	Species:	Mus musculus

Alignment Length:	529	Identity:	101/529 - (19%)
Similarity:	165/529 - (31%)	Gaps:	230/529 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 GVLPHLHSLSLKRCLP------LFMSGSFLDSYNNSCPDLNDLASNLAGIKELTLCENQYLTDAI 182
            |:.|.||:..|...||      :.:.|.....:...|         |.|:.:|.:||
Mouse   232 GLTPVLHAKELYNVLPGGEKEFVNLQGFAARGFEGFC---------LVGVSDLDICE-------- 279

  Fly   183 LMRLTSFMPSLEAINMSGCHIAFHNAIHRRFYPATSSSDHVLPSESVLTFKFILTILNLQRRTLR 247
                                                                .:...:|.::.::
Mouse   280 ----------------------------------------------------FIDNYSLSKKGVK 292

  Fly   248 VLNFSHTLIGQALLALCDLNLQ-LQRLYLAGCRQLNCTTILNFLATQPQLCALDLSATMCVN--D 309
            .::...:.|..|.|.:....:| :.||.|:||.......:.:.|:.:    ...||.:.|:|  |
Mouse   293 AMSLKRSTITDAGLEVMLEQMQGVVRLELSGCNDFTEAGLWSSLSAR----ITSLSVSDCINVAD 353

  Fly   310 ENLAALVQTNPQLEHLKVN--------------------------GCLSITNAGAIHLA-KLKCL 347
            :.:||:.|..|.|..|.:.                          .|..|||.|.:::. .|..|
Mouse   354 DAIAAISQLLPNLAELSLQAYHVTDTALAYFTARQGHSTHTLRLLSCWEITNHGVVNVVHSLPNL 418

  Fly   348 KSLDISNCDNLTSSGIIEGIASEENPVIQELNVSYLQICEECIKAIASNLRCLRSLHLNHCVNGA 412
            .||.:|.|..:|..|                           ::.:|.|||.||||.|:.|.. .
Mouse   419 TSLSLSGCSKVTDDG---------------------------VELVAENLRKLRSLDLSWCPR-I 455

  Fly   413 TDEAIQSVIGQLRWLRELSLEHCSGLTDAALTGINISKLEMSRKQSGSQVSSMDNFYPPYSNTLA 477
            ||.|::.|...|..|.||.|:.|..:||..|:                           |.:|::
Mouse   456 TDMALEYVACDLHRLEELVLDRCVRITDTGLS---------------------------YLSTMS 493

  Fly   478 ERDSLAGSLQSIKISLRSKAEDEIVRDARRKQAMLAAYEMNLIREDDFEGHNIQQLRGLRSLNLR 542
                                                                     .||||.||
Mouse   494 ---------------------------------------------------------SLRSLYLR 501

  Fly   543 GCNKISDVSLKYGLKHI----ELRRLMLSNCQQISLLGMEAMASSCPSIEELDLSDCYNITDKTI 603
            .|.::.|    :||||:    .||.|.|:.|..::..|:..:. ....:|||:|::|...|.:..
Mouse   502 WCCQVQD----FGLKHLLAMRNLRLLSLAGCPLLTTTGLSGLV-QLQELEELELTNCPGATPELF 561

  Fly   604 QVVTSKLPR 612
            :..:..|||
Mouse   562 KYFSQHLPR 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8272	NP_001260812.1	AMN1	269..440	CDD:187754	51/200 (26%)
		leucine-rich repeat	270..295	CDD:275381	6/24 (25%)
		leucine-rich repeat	296..319	CDD:275381	8/24 (33%)
		leucine-rich repeat	322..346	CDD:275381	8/50 (16%)
		leucine-rich repeat	347..399	CDD:275381	10/51 (20%)
		leucine-rich repeat	400..426	CDD:275381	11/25 (44%)
		leucine-rich repeat	427..535	CDD:275381	10/107 (9%)
		AMN1	515..>642	CDD:187754	27/102 (26%)
		leucine-rich repeat	536..560	CDD:275381	12/27 (44%)
		leucine-rich repeat	561..586	CDD:275381	6/24 (25%)
		leucine-rich repeat	587..612	CDD:275381	7/24 (29%)
		leucine-rich repeat	613..638	CDD:275381	101/529 (19%)
		leucine-rich repeat	639..663	CDD:275381
		F-box-like	12..>44	CDD:289689
		leucine-rich repeat	129..166	CDD:275381	8/42 (19%)
		leucine-rich repeat	167..192	CDD:275381	3/24 (13%)
		leucine-rich repeat	193..244	CDD:275381	1/50 (2%)
		C2	<231..274	CDD:301316	6/43 (14%)
		leucine-rich repeat	246..269	CDD:275381	3/22 (14%)
Fbxl16	NP_001366323.1	PHA03247	<31..193	CDD:223021
		AMN1	297..509	CDD:187754	67/331 (20%)
		leucine-rich repeat	316..339	CDD:275381	6/22 (27%)
		leucine-rich repeat	340..365	CDD:275381	8/24 (33%)
		leucine-rich repeat	366..391	CDD:275381	2/24 (8%)
		leucine-rich repeat	392..417	CDD:275381	6/24 (25%)
		leucine-rich repeat	418..443	CDD:275381	10/51 (20%)
		leucine-rich repeat	444..469	CDD:275381	11/25 (44%)
		leucine-rich repeat	470..494	CDD:275381	10/107 (9%)
		leucine-rich repeat	495..514	CDD:275381	11/22 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810