Protein Alignment CG8272 and AMN1

DIOPT Version :9

• Sequence 1: NP_001260812.1
• Gene: CG8272 / 35875
• FlyBaseID: FBgn0033337
• Length: 710
• Species: Drosophila melanogaster
• Sequence 2: NP_001106873.1
• Gene: AMN1 / 196394
• HGNCID: 27281
• Length: 258
• Species: Homo sapiens
• Alignment Length: 328
• Identity: 63/328 - (19%)
• Similarity: 116/328 - (35%)
• Gaps: 138/328 - (42%)

  Fly   307 VNDENLAALVQTNPQLEHLKVNGCLSITNAGAIHLAKLKCLKSLDISNCDNLTSSGIIEGIASEE 371
            :.|.|::.::  :|:::.|.:..| .|::|..:||:..:.||.|:::              ||:.
Human    50 ITDSNISEIL--HPEVQTLDLRSC-DISDAALLHLSNCRKLKKLNLN--------------ASKG 97

  Fly   372 NPVIQELNVSYLQICEECIKAIASNLRCLRSLHLNHCVNGATDEAIQSVIGQLRWLRELSLEHCS 436
            |.|         .:..|.|||:||:           |                .:|.|.||:.|.
Human    98 NRV---------SVTSEGIKAVASS-----------C----------------SYLHEASLKRCC 126

  Fly   437 GLTDAALTGINISKLEMSRKQSGSQVSSMDNFYPPYSNTLAERDSLAGSLQSIKISLRSKAEDEI 501
            .|||..:.                                    :||.:.|.:||
Human   127 NLTDEGVV------------------------------------ALALNCQLLKI---------- 145

  Fly   502 VRDARRKQAMLAAYEMNLIREDDFEGHNIQQLRGLRSLNLRGCNKISDVSLKYGLKHIELRRLML 566
                                                 ::|.||..|:||||....|:....:.:.
Human   146 -------------------------------------IDLGGCLSITDVSLHALGKNCPFLQCVD 173

  Fly   567 SNCQQISLLGMEAMASS--CPSIEELDLSDCYNITDKTIQVVTSKLPRLKALHISGCSQLTEHTL 629
            .:..|:|..|:.|:.|.  ...:||:.:..|.|:||..::.|.:..|:::.|...||..:|:|:.
Human   174 FSATQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRILLFHGCPLITDHSR 238

  Fly   630 DAI 632
            :.:
Human   239 EVL 241

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8272	NP_001260812.1	AMN1	269..440	CDD:187754	29/132 (22%)
		leucine-rich repeat	270..295	CDD:275381
		leucine-rich repeat	296..319	CDD:275381	2/11 (18%)
		leucine-rich repeat	322..346	CDD:275381	6/23 (26%)
		leucine-rich repeat	347..399	CDD:275381	13/51 (25%)
		leucine-rich repeat	400..426	CDD:275381	1/25 (4%)
		leucine-rich repeat	427..535	CDD:275381	13/107 (12%)
		AMN1	515..>642	CDD:187754	27/120 (23%)
		leucine-rich repeat	536..560	CDD:275381	9/23 (39%)
		leucine-rich repeat	561..586	CDD:275381	5/26 (19%)
		leucine-rich repeat	587..612	CDD:275381	7/24 (29%)
		leucine-rich repeat	613..638	CDD:275381	5/20 (25%)
		leucine-rich repeat	639..663	CDD:275381
		F-box-like	12..>44	CDD:289689
		leucine-rich repeat	129..166	CDD:275381
		leucine-rich repeat	167..192	CDD:275381
		leucine-rich repeat	193..244	CDD:275381
		C2	<231..274	CDD:301316
		leucine-rich repeat	246..269	CDD:275381
AMN1	NP_001106873.1	AMN1	37..257	CDD:187754	63/328 (19%)
		leucine-rich repeat	63..86	CDD:275381	6/23 (26%)
		leucine-rich repeat	87..116	CDD:275381	14/78 (18%)
		leucine-rich repeat	117..142	CDD:275381	10/60 (17%)
		leucine-rich repeat	143..168	CDD:275381	11/71 (15%)
		leucine-rich repeat	169..195	CDD:275381	5/25 (20%)
		leucine-rich repeat	196..221	CDD:275381	7/24 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900